Successful management of primary hypercholesterolaemia with simvastatin and low-dose colestipol.

Author: ParfittA, SimonsJ, SimonsL A

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To examine whether a small dose of bile acid sequestrant used in combination with a hydroxymethylglutaryl coenzyme A reductase inhibitor is more effective in reducing serum and low-density lipoprotein (LDL) cholesterol levels than inhibitor used alone. DESIGN: A randomised, double-blind ...See full text at original site
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引用元:
https://doi.org/10.5694/j.1326-5377.1992.tb137306.x

データ提供:米国国立医学図書館(NLM)

Combating High Cholesterol: A Desert Oasis of Effective Treatment

This research explores the effectiveness of combining simvastatin, a statin medication, with low-dose colestipol, a bile acid sequestrant, in treating high cholesterol. It's like discovering a synergistic blend of desert plants that, when combined, offer a more potent solution than either plant alone.

A Potent Combination: Harnessing the Power of Synergy

The study demonstrates that combining simvastatin with low-dose colestipol leads to a greater reduction in serum cholesterol levels compared to simvastatin alone. It's like finding that combining two types of desert plants with unique properties can result in a more effective remedy. This research highlights the potential for synergistic effects in drug combinations, offering a more effective approach to managing high cholesterol.

A Safer Approach: Finding Balance in the Desert of Treatment

The research also suggests that the combination therapy is well-tolerated, with fewer gastrointestinal side effects compared to higher doses of colestipol alone. It's like finding a safe and sustainable path through the desert, minimizing the risk of encountering harsh conditions. This research provides valuable insights into the potential for safe and effective treatment strategies for high cholesterol, offering a more balanced approach to managing this prevalent health issue.

Dr.Camel's Conclusion

This research demonstrates the potential benefits of combining simvastatin with low-dose colestipol in managing high cholesterol. It's like finding a hidden oasis in the desert, offering a safe and effective solution to a common health problem. This research encourages us to explore the potential for synergistic effects in drug combinations, seeking innovative and effective ways to address health challenges.

Date :
  1. Date Completed 1992-10-28
  2. Date Revised 2021-01-07
Further Info :

Pubmed ID

1406395

DOI: Digital Object Identifier

10.5694/j.1326-5377.1992.tb137306.x

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PICO Info
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Languages

English

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