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[Anti-emetic effect and safety of single dose of ondansetron injection in double-blind comparison study with placebo].

Author: AkasakaY, AriyoshiY, FurueH, IkedaM, NiitaniH, OhtaJ, OtaK, SuminagaM, TaguchiT, TsukagoshiS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
English AbstractA summary of a research paper/publication written in English for a wider audience.

Overview

Ondansetron injection was found to be significantly more effective than placebo in preventing nausea and vomiting associated with cancer chemotherapy. In a double-blind, placebo-controlled study, 66.7% of patients receiving ondansetron had good anti-emetic effects, compared to only 20% of patients receiving placebo. Ondansetron was also found to be well tolerated with few side effects.
Paper Details　
Original Abstract of the Article :
In order to make an objective evaluation of anti-emetic effect, safety and usefulness of ondansetron injection in nausea and vomiting associated with cancer chemotherapy, we carried out a double-blind placebo controlled comparative study in patients receiving high-single dose (50 mg/m2 or more) of c...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1417013

データ提供：米国国立医学図書館（NLM）

[Anti-emetic effect and safety of single dose of ondansetron injection in double-blind comparison study with placebo]

This double-blind, placebo-controlled study evaluated the anti-emetic effect and safety of a single dose of ondansetron injection in patients receiving high-dose cisplatin chemotherapy. The study found that ondansetron was significantly superior to placebo in reducing nausea and vomiting associated with cisplatin chemotherapy. The efficacy rate was significantly higher in the ondansetron group compared to the placebo group. Additionally, the study demonstrated that ondansetron was well-tolerated, with minimal side effects observed. The findings suggest that ondansetron is an effective and safe anti-emetic agent for preventing and managing nausea and vomiting associated with highly emetogenic chemotherapy regimens.

Ondansetron: a safe and effective anti-emetic for chemotherapy

This study provides strong evidence that ondansetron is a safe and effective anti-emetic agent for preventing and managing nausea and vomiting associated with highly emetogenic chemotherapy regimens like cisplatin. The study highlights the importance of effective anti-emetic therapy in improving the quality of life for cancer patients undergoing chemotherapy.

Health implications and everyday applications

Patients undergoing highly emetogenic chemotherapy can potentially benefit from ondansetron to manage nausea and vomiting, improving their overall comfort and well-being. It is recommended that patients discuss this treatment option with their oncologist.

Dr.Camel's Conclusion

Navigating the challenges of cancer treatment can be a difficult journey. This study provides a ray of hope by demonstrating the effectiveness and safety of ondansetron, offering a valuable tool for managing the distressing side effects of chemotherapy.

Date :
  1. Date Completed 1992-11-06
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

1417013

DOI: Digital Object Identifier

1417013

SNS
PICO Info
in preparation
Languages

Japanese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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