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Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression.

Author: BakerRobert W, BeymerKarin, BowdenCharles, BreierAlan, CalabreseJoseph, CentorrinoFranca, DubeSanjay, EvansAngela R, KetterTerence A, MitchellPhilip B, RisserRichard, SachsGary, TohenMauricio, TollefsonGary D, VietaEduard

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the effectiveness of olanzapine and a combination of olanzapine and fluoxetine in treating bipolar I depression. The study found that both olanzapine and olanzapine-fluoxetine were more effective than placebo at reducing depressive symptoms, with olanzapine-fluoxetine showing greater improvement than olanzapine alone at weeks 4 through 8. Neither treatment was associated with an increased risk of developing manic symptoms.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Despite the longer duration of the depressive phase in bipolar disorder and the frequent clinical use of antidepressants combined with antipsychotics or mood stabilizers, relatively few controlled studies have examined treatment strategies for bipolar depression. OBJECTIVE: To examine t...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/14609883

データ提供：米国国立医学図書館（NLM）

Navigating Bipolar Depression: Olanzapine and Olanzapine-Fluoxetine Combination Therapy

Bipolar depression, a relentless cycle of highs and lows, presents significant challenges for patients and healthcare providers alike. This research explores the effectiveness of two potential treatments: olanzapine, a medication commonly used for bipolar disorder, and a combination therapy involving olanzapine and fluoxetine, an antidepressant. The authors undertook a large-scale, double-blind, randomized controlled trial to compare these treatment options, meticulously evaluating their impact on depressive symptoms in individuals with bipolar I depression. The results of this study showcase the efficacy of both olanzapine and the olanzapine-fluoxetine combination in reducing depressive symptoms, offering valuable insights into treatment options for bipolar depression.

Olanzapine and Olanzapine-Fluoxetine Combination: Hope for Individuals with Bipolar Depression

This study presents a compelling argument for the effectiveness of olanzapine and olanzapine-fluoxetine combination therapy in managing bipolar depression. Both treatments demonstrated significant improvement in depressive symptoms compared to a placebo group, offering a beacon of hope for individuals struggling with this complex condition. The olanzapine-fluoxetine combination even surpassed the effectiveness of olanzapine alone, suggesting a potential advantage for this specific combination therapy. This research provides valuable guidance for healthcare professionals, offering evidence-based support for these treatment options.

Living with Bipolar Depression: Seeking Effective Treatment

The findings of this study are significant for individuals living with bipolar depression. It offers valuable information about potential treatment options that have been shown to effectively reduce depressive symptoms. It's crucial to consult with a qualified healthcare professional to explore the most appropriate treatment plan for your individual needs. This study emphasizes the importance of seeking professional guidance and adhering to a personalized treatment plan. Remember, with proper treatment and support, individuals with bipolar depression can navigate their condition and live fulfilling lives.

Dr.Camel's Conclusion

This study is a testament to the power of research in providing valuable insights into the management of complex conditions like bipolar depression. The authors conducted a rigorous study comparing different treatment options, ultimately shedding light on the effectiveness of olanzapine and olanzapine-fluoxetine combination therapy. This research offers hope for individuals with bipolar depression, highlighting the importance of seeking professional guidance to develop a tailored treatment plan that addresses their unique needs.

Date :
  1. Date Completed 2004-02-17
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

14609883

DOI: Digital Object Identifier

60/11/1079

Related Literature

Article Analysis
・Effective treatment of bipolar disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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