Effective treatment of bipolar disorder: A Synthesis of Findings from 128 Studies

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Original Abstract of the Article

Major Research Findings

Bipolar disorder is a mental illness characterized by alternating periods of mania and depression. Treatment for bipolar disorder typically involves a combination of medication and therapy. Medications are used to help control the symptoms of mania and depression, while therapy is used to improve the patient's quality of life and prevent symptom recurrence. 70 , 118 , 36 , 127 , 27 , 43 , 119 , 90 , 95 , 72 , 37 , 45 , 35 , 23 , 96 , 69 , 93 , 18 , 126 , 48 , 79 , 104

Treatment Summary

A variety of medications are used to treat bipolar disorder. For example, lithium is often prescribed to prevent and treat mania. Valproic acid is commonly used to treat mania, depression, and mixed states. These medications may be used in combination with antipsychotics, antianxiety medications, or antidepressants. 54 , 120 , 110 , 116 , 16 , 128 , 34 , 123

Psychological treatments that may be helpful include cognitive behavioral therapy (CBT), family therapy, and psychoeducation. CBT aims to improve symptoms by helping patients identify and modify negative thought and behavior patterns. Family therapy focuses on improving family interactions to help prevent symptom recurrence. Psychoeducation provides patients and families with accurate information about bipolar disorder to improve understanding of the illness and enhance symptom management. 43 , 3 , 106 , 115 , 50 , , 31 , 52 , 28 , 123 , 96 , 93 , 18 , 37 , 35 , 23 , 90 , 95

Benefits and Risks

Benefit Summary

Treatment for bipolar disorder can help control the symptoms of mania and depression, improving quality of life. It can also help prevent symptom recurrence. 70 , 118 , 36 , 127 , 27 , 43 , 119 , 90 , 95 , 72 , 37 , 45 , 35 , 23 , 96 , 69 , 93 , 18 , 126 , 48 , 79 , 104

Risk Summary

Treatment for bipolar disorder can have side effects. For example, lithium can cause side effects like hand tremor, weight gain, and hypothyroidism. Valproic acid can cause side effects such as liver problems, weight gain, and hair loss. Antipsychotics can cause side effects including weight gain, diabetes, and high cholesterol. 54 , 120 , 110 , 116 , 16 , 128 , 34 , 123

Comparison Between Studies

Commonalities Between Studies

Many studies suggest that both medication and therapy are important for the treatment of bipolar disorder. 70 , 118 , 36 , 127 , 27 , 43 , 119 , 90 , 95 , 72 , 37 , 45 , 35 , 23 , 96 , 69 , 93 , 18 , 126 , 48 , 79 , 104

Differences Between Studies

The specific effective treatment methods and potential side effects can vary between studies. For example, one study may demonstrate lithium's effectiveness in preventing mania, while another might highlight valproic acid's effectiveness in treating mania. 54 , 120 , 110 , 116 , 16 , 128 , 34 , 123

Consistency and Contradictions in Findings

Research on the treatment of bipolar disorder is not yet comprehensive. Consequently, there may be inconsistencies or contradictions in the research findings. For instance, some studies indicate that antidepressants are ineffective in treating bipolar depression, while others suggest that antidepressants can be effective in treating this aspect of the disorder. 70 , 118 , 36 , 127 , 27 , 43 , 119 , 90 , 95 , 72 , 37 , 45 , 35 , 23 , 96 , 69 , 93 , 18 , 126 , 48 , 79 , 104

Considerations for Real-Life Application

Treatment for bipolar disorder is tailored to the individual patient's condition and symptoms. It is essential to consult with a doctor before starting any treatment. Regular follow-up appointments with your doctor are also crucial during treatment. 54 , 120 , 110 , 116 , 16 , 128 , 34 , 123

Limitations of Current Research

Research on the treatment of bipolar disorder is still in its early stages. In particular, there is a lack of research on long-term effects and side effects. 70 , 118 , 36 , 127 , 27 , 43 , 119 , 90 , 95 , 72 , 37 , 45 , 35 , 23 , 96 , 69 , 93 , 18 , 126 , 48 , 79 , 104

Future Research Directions

Research on the treatment of bipolar disorder needs to continue moving forward. It is especially important to conduct research on long-term effects and side effects, develop new treatment methods, and create treatment approaches that are tailored to individual patient needs. 54 , 120 , 110 , 116 , 16 , 128 , 34 , 123

Conclusion

Bipolar disorder is a mental illness characterized by alternating periods of mania and depression. Treatment for bipolar disorder typically involves a combination of medication and therapy. However, research in this area is still insufficient, and more research is needed. Treatment for bipolar disorder is tailored to the individual patient's condition and symptoms. It is essential to consult with a doctor before starting any treatment. 70 , 118 , 36 , 127 , 27 , 43 , 119 , 90 , 95 , 72 , 37 , 45 , 35 , 23 , 96 , 69 , 93 , 18 , 126 , 48 , 79 , 104

Treatment List

Lithium, Valproic acid, Antipsychotics, Antianxiety medications, Antidepressants, Cognitive Behavioral Therapy (CBT), Family therapy, Psychoeducation

Keywords
Benefit Keywords
Control of mania
1
Safe coadministration
2
Improved bipolar disorder treatment
3
Improved bipolar disorder treatment
5
Improved understanding of bipolar disorder
7
Useful treatment for some patients with rapid-cycling bipolar disorder
Well tolerated
8
Antimanic properties
9
Improved functional recovery
11
Effective treatment of acute bipolar episodes
12
Improved mood stability
13
Olanzapine efficacy
Olanzapine-fluoxetine efficacy
14
Improved mood
Manic episode treatment
15
Improved understanding of bipolar disorder
16
RC bipolar disorder treatment
17
Reduced relapse rates in BDs
18
Bipolar disorder treatment
20
Bipolar depression reduction
21
Improved bipolar disorder treatment
Increased effectiveness of treatment
22
Improved bipolar disorder treatment
Increased treatment adherence
Reduced relapses
23
Improved bipolar disorder treatment
Reduced mood episodes
24
Improved bipolar disorder treatment
25
Improved diagnosis
26
Improved bipolar disorder treatment
Reduced relapses
27
Reduced mania symptoms
28
Improved bipolar disorder management
29
Reduced bipolar disorder relapse
30
Improved bipolar disorder treatment
31
Improved bipolar disorder treatment
32
Improved bipolar disorder treatment
Increased treatment compliance
33
Improved bipolar disorder treatment
34
Improved bipolar disorder treatment
Reduced bipolar episodes
35
Improved bipolar depression treatment
36
Relapse prevention
Symptom treatment
37
Reduced relapse
39
Improved bipolar affective disorder treatment
40
Improved bipolar disorder treatment
41
Improved bipolar disorder treatment
42
Improved bipolar disorder treatment
43
Improved bipolar disorder treatment
44
Improved bipolar I disorder treatment
45
Improved bipolar disorder treatment
46
Improved bipolar disorder treatment
47
None specified
48
Improved manic symptoms
Prevents relapses
49
Bipolar disorder treatment
50
Bipolar disorder treatment
51
Bipolar disorder treatment
52
Bipolar disorder treatment
53
BD treatment
54
Bipolar depression treatment
55
Increased remission rates
Increased response rates
56
Improved manic symptoms
Long-term efficacy
57
Bipolar depression treatment
58
BD treatment
59
BD treatment
61
Bipolar disorder treatment
62
Treatment of bipolar disorder
63
Management of bipolar disorder
64
Treatment of bipolar disorder
65
Treatment of bipolar disorder
66
Treatment of bipolar disorder
67
Treatment of bipolar mania
68
Reduced anxiety
69
Bipolar disorder treatment
72
Bipolar depression treatment
73
Mood stabilization
74
BD treatment
75
Bipolar disorder treatment
76
Bipolar disorder treatment
77
Bipolar disorder treatment
78
Bipolar depression treatment
79
Reduced TNF-α
80
Bipolar disorder treatment
81
BD and BPD treatment
82
BD-OCD treatment
83
Improved bipolar disorder symptoms
84
No weight gain
Reduced manic symptoms
Well tolerated
85
Bipolar disorder treatment
86
BD treatment
87
Effective manic episode treatment
88
BD treatment
89
Bipolar disorder treatment
90
Reduced bipolar depression
91
Bipolar disorder treatment
92
Bipolar disorder treatment
93
Bipolar disorder treatment
94
Bipolar disorder treatment
95
AIBD
BD treatment
96
BD treatment
SZ treatment
97
Bipolar disorder treatment
Depressive symptoms
98
BD treatment
99
BD-OCD treatment
100
BD I treatment
Risperidone
101
BD treatment
MBCT
102
Bipolar disorder treatment
Lithium
103
Total mortality reduction
104
Symptom management
105
BIPOLIFE for adherence
106
BSD treatment
107
Resistant bipolar disorder treatment
108
No aggravation of symptoms
109
Reduced bipolar symptomatology
110
Improved general functioning
111
Bipolar depression treatment
112
Bipolar disorder treatment
113
TRBD treatment
114
Anxiety treatment
115
Bipolar disorder treatment
116
Bipolar disorder treatment
118
Bipolar disorder treatment
119
No increased mood switch
Well tolerated
120
Bipolar disorder treatment
121
BP disorder treatment
122
Bipolar disorder treatment
123
Bipolar disorder treatment
125
Improved emotion regulation
126
Bipolar depression treatment
127
BD treatment
128
Risk Keywords
Longer time to remission
Non-remission
Severe side effects
6
Chronicity
Frequent episodes
Frequent switches between mania and depression
High recurrence rate
Poor prognosis
Suicide
7
Side effects
9
Potential negative influence on bipolar illness
10
Diarrhea
Mania risk
Nausea
14
Weight gain
15
Worsening of bipolar disorder with conventional antidepressants
20
Mania
21
Bipolar disorder
22
Bipolar disorder
23
Bipolar disorder
24
Bipolar disorder
Treatment resistance
25
Bipolar disorder
27
Bipolar disorder
30
Bipolar disorder
31
Bipolar disorder
32
Bipolar disorder
33
Bipolar disorder
34
Bipolar disorder
35
Bipolar depression
36
Weight gain
38
Adverse events
39
Bipolar affective disorder
40
Bipolar disorder
41
Bipolar disorder
42
Bipolar disorder
43
Bipolar disorder
44
Bipolar I disorder
45
Bipolar disorder
46
Bipolar disorder
47
None specified
48
Depression
Weight gain
49
Cognitive side effects
55
Suicide
Switching
Weight gain
56
Side effects
57
Poorer treatment outcomes
60
Side effects
66
Weight gain
69
Antidepressant mood switching
BPD diagnosis
70
Treatment resistance
71
Mood-switching
73
Abdominal pain
Headache
Tremor
Vomiting
74
Extrapyramidal symptoms
Glucose and lipid abnormalities
Weight gain
84
Thyrotropin increase
85
Gastrointestinal issues
Neurological issues
Sedation
Weight gain
88
Mania/hypomania risk
91
Anxiolytic and hypnotic side effects
97
Side effects
110
measurement bias
publication bias
114
(Hypo)manic relapse
Illness onset risk
117
None reported
126
Literature analysis of 128 papers
Positive Content
117
Neutral Content
4
Negative Content
7
Article Type
61
33
52
49
128
1.

Dysphoric mania.

Author: ClothierJ, SwannA C, FreemanT

Control of mania

Lithium is the primary treatment for bipolar disorder, but patients with syndromal variations, such as those experiencing mixed states or dysphoria, have a poorer response. A study comparing lithium and valproate for mania control found that pretreatment depression scores were higher in patients responding to valproate. Further research is needed on mixed or dysphoric manic states and predictors of response to treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Pharmacokinetic interactions and side effects resulting from concomitant administration of lithium and divalproex sodium.

Author: GrannemanG R, SchneckD W, CavanaughJ H, WittG F

Safe coadministration

Co-administration of lithium and valproate was safe in healthy volunteers. Lithium pharmacokinetics remained unchanged, but valproate levels increased slightly.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

New psychosocial treatments for the outpatient management of bipolar disorder.

Author: MiklowitzD J, FrankE, GeorgeE L

Improved bipolar disorder treatment

Two types of psychotherapy—family-focused education and individual, interpersonal therapy—are being studied as potential additions to medication treatment for bipolar disorder. These therapies aim to strengthen support systems and improve medication adherence. Initial findings show that both therapies are effective in keeping patients engaged in treatment for a year. Future research should focus on the best way to combine medication and psychotherapy, and identify the factors that make psychotherapy most effective for bipolar disorder.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

Bipolar depression: an underestimated treatment challenge.

Author: HlastalaS A, FrankE, MallingerA G, ThaseM E, RitenourA M, KupferD J

In a study of 42 people with bipolar disorder, those experiencing mania were more likely to achieve remission with medication than those with depression (100% vs. 59%). There was no significant difference between the remission rates for those with depression and those with mixed or cycling episodes. While the study did not find a significant effect of the type of non-medication treatment, it suggests that psychotherapy may have a limited impact during the acute phase of bipolar disorder. These findings highlight the need for more effective treatments for bipolar depression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

5.

Adjunctive psychotherapy for bipolar disorder: effects of changing treatment modality.

Author: FrankE, SwartzH A, MallingerA G, ThaseM E, WeaverE V, KupferD J

Improved bipolar disorder treatment

In a study of 82 people with bipolar disorder, those who continued the same treatment (interpersonal and social rhythm therapy [IPSRT] or intensive clinical management [CM]) for both the acute and long-term phases of their illness had lower rates of relapse and fewer symptoms compared to those who switched treatments. This suggests that consistent psychosocial treatment may be important for better outcomes in bipolar disorder.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

6.

Anxiety as a correlate of response to the acute treatment of bipolar I disorder.

Author: FeskeU, FrankE, MallingerA G, HouckP R, FagioliniA, ShearM K, GrochocinskiV J, KupferD J

Longer time to remission
Non-remission
Severe side effects

Anxiety is a clinically meaningful correlate of poor outcome in the acute treatment of bipolar I disorder.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

7.

Historical perspectives and natural history of bipolar disorder.

Author: AngstJ, SellaroR

Improved understanding of bipolar disorder
Chronicity
Frequent episodes
Frequent switches between mania and depression
High recurrence rate
Poor prognosis
Suicide

A review of research on bipolar disorder over two centuries, including a long-term study of 220 people with the condition, found that bipolar disorder is a highly recurrent and severe illness. People with bipolar disorder spend about 20% of their lives experiencing episodes, with episodes lasting an average of 3 months. While modern medications can help manage episodes, most people still experience relapses, incomplete recovery, and long-term difficulties. The risk of suicide is also high.

Historical ArticleA research paper that analyzes past events and developments using primary sources and examines them from a historical perspective.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

8.

A double-blind, placebo-controlled, prophylaxis study of lamotrigine in rapid-cycling bipolar disorder. Lamictal 614 Study Group.

Author: CalabreseJ R, SuppesT, BowdenC L, SachsG S, SwannA C, McElroyS L, KusumakarV, AscherJ A, EarlN L, GreeneP L, MonaghanE T

Useful treatment for some patients with rapid-cycling bipolar disorder
Well tolerated

Lamotrigine monotherapy may be a useful treatment for some patients with rapid-cycling bipolar disorder. In a study of 324 patients, lamotrigine was well tolerated and showed a statistically significant difference in survival in study compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

A meta-analysis of the use of typical antipsychotic agents in bipolar disorder.

Author: TohenM, ZhangF, TaylorC C, BurnsP, ZarateC, SangerT, TollefsonG

Antimanic properties
Side effects

Typical antipsychotic agents are commonly used in the treatment of bipolar disorder, with an 84.7% prevalence rate. This may be due to dissatisfaction with mood stabilizer monotherapy, high prevalence of psychotic symptoms in mania, and unavailability or unfamiliarity with new treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Clinical significance of lifetime panic spectrum symptoms in the treatment of patients with bipolar I disorder.

Author: FrankEllen, CyranowskiJill M, RucciPaola, ShearM Katherine, FagioliniAndrea, ThaseMichael E, CassanoGiovanni B, GrochocinskiVictoria J, KostelnikBryan, KupferDavid J

Potential negative influence on bipolar illness

This study investigated the impact of panic disorder and related conditions on the course and treatment of bipolar I (BPI) disorder. The researchers hypothesized that people with a history of panic disorders would have a higher risk of suicidal thoughts and would respond less well to treatment for their current mood episode.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

11.

Schema-focused cognitive therapy for bipolar disorder: reducing vulnerability to relapse through attitudinal change.

Author: BallJillian, MitchellPhilip, MalhiGin, SkillecornAshleigh, SmithMeg

Improved functional recovery

How people adapt to and cope with bipolar disorder is important for following treatment plans and improving their overall functioning. This paper examines the social and psychological factors related to bipolar disorder and the role of psychological interventions in managing symptoms and adapting to the illness. The authors propose a new model that considers a person's past experiences and temperament in understanding their response to bipolar disorder. They suggest that therapy that focuses on changing thoughts and feelings related to the illness and its impact on self-image may help people with bipolar disorder who are not functioning as well as they could.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Valproate for acute mood episodes in bipolar disorder.

Author: MacritchieK, GeddesJ R, ScottJ, HaslamD, de LimaM, GoodwinG

Effective treatment of acute bipolar episodes

Bipolar disorder is a common condition that causes severe mood swings. Effective treatment for the intense mood episodes is crucial. Valproate has become an important additional or alternative treatment to lithium for managing bipolar disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

A randomized study of family-focused psychoeducation and pharmacotherapy in the outpatient management of bipolar disorder.

Author: MiklowitzDavid J, GeorgeElizabeth L, RichardsJeffrey A, SimoneauTeresa L, SuddathRichard L

Improved mood stability

This study investigated whether adding family-focused therapy to medication treatment during the period after a bipolar episode improves mood stability in the long term.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

14.

Efficacy of olanzapine and olanzapine-fluoxetine combination in the treatment of bipolar I depression.

Author: TohenMauricio, VietaEduard, CalabreseJoseph, KetterTerence A, SachsGary, BowdenCharles, MitchellPhilip B, CentorrinoFranca, RisserRichard, BakerRobert W, EvansAngela R, BeymerKarin, DubeSanjay, TollefsonGary D, BreierAlan

Olanzapine efficacy
Olanzapine-fluoxetine efficacy
Diarrhea
Mania risk
Nausea

This study compared the effectiveness of olanzapine and a combination of olanzapine and fluoxetine in treating bipolar I depression. The study found that both olanzapine and olanzapine-fluoxetine were more effective than placebo at reducing depressive symptoms, with olanzapine-fluoxetine showing greater improvement than olanzapine alone at weeks 4 through 8. Neither treatment was associated with an increased risk of developing manic symptoms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Risperidone in combination with mood stabilizers: a 10-week continuation phase study in bipolar I disorder.

Author: BowdenCharles L, MyersJoyce E, GrossmanFred, XieYang

Improved mood
Manic episode treatment
Weight gain

The combination of risperidone and mood stabilizers is effective and well tolerated for continuing treatment of patients hospitalized for acute manic episodes. It significantly reduces manic symptoms and improves overall mental state.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Mixed versus manic bipolar disorder: a comparison of demographic, symptomatic, and treatment differences.

Author: ShahNurun N, AverillPatricia M, ShackAndrew

Improved understanding of bipolar disorder

This study compared people with a mixed bipolar episode to those with a manic bipolar episode. While there were no differences in age, race, episode frequency, or length of stay in the hospital, women were more likely to have a mixed episode, while men were more likely to have a manic episode. People with a manic episode had more resistance to treatment, psychotic symptoms, and disorganized thinking. Those with mixed episodes had more symptoms of depression and anxiety. People with mixed episodes were more likely to be prescribed antidepressants at discharge.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Comparison of rapid-cycling and non-rapid-cycling bipolar I manic patients during treatment with olanzapine: analysis of pooled data.

Author: VietaEduard, CalabreseJoseph R, HennenJohn, ColomFrancesc, Martínez-AránAnabel, Sánchez-MorenoJose, YathamLakshmi N, TohenMauricio, BaldessariniRoss J

RC bipolar disorder treatment

Rapid-cycling (RC) bipolar disorder is associated with significant health problems and often responds poorly to existing treatments. This study is the first controlled trial to compare the immediate and long-term effects of olanzapine in patients with RC bipolar disorder and those with non-RC bipolar disorder.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

The current status of psychological treatments in bipolar disorders: a systematic review of relapse prevention.

Author: ScottJan, GutierrezMaria Jose

Reduced relapse rates in BDs

This research examines studies comparing the effectiveness of adding psychotherapy to standard psychiatric treatment for bipolar disorder (BD) versus medication and standard treatment alone. The aim is to determine whether psychotherapy reduces the likelihood of relapses in individuals with BD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Rapid cycling bipolar disorder: historical overview and focus on emerging treatments.

Author: MackinPaul, YoungAllan H

Rapid-cycling bipolar disorder is particularly challenging to treat. The cyclical nature of bipolar disorder has been understood for over a century, and since a landmark study in 1974, researchers have focused on defining rapid-cycling, understanding its characteristics, and exploring treatment responses and medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Divalproex in the treatment of bipolar depression: a placebo-controlled study.

Author: DavisLori L, BartolucciAl, PettyFrederick

Bipolar disorder treatment
Worsening of bipolar disorder with conventional antidepressants

Treating the depressed phase of bipolar disorder is tricky because typical antidepressants can sometimes trigger manic episodes or make the illness worse. This study investigates the potential of mood stabilizers, such as divalproex (effective for manic episodes), to also treat depression in bipolar disorder.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

21.

Analyses of treatment-emergent mania with olanzapine/fluoxetine combination in the treatment of bipolar depression.

Author: KeckPaul E, CoryaSara A, AltshulerLori L, KetterTerence A, McElroySusan L, CaseMichael, BriggsSusan D, TohenMauricio

Bipolar depression reduction
Mania

Olanzapine/fluoxetine combination did not present a greater risk of treatment-emergent mania compared to olanzapine or placebo over 8 weeks of acute treatment for bipolar I depression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Psychoeducation: improving outcomes in bipolar disorder.

Author: ColomFrancesc, LamDominic

Improved bipolar disorder treatment
Increased effectiveness of treatment
Bipolar disorder

Treatment for bipolar disorder has shifted towards a combination of medication and psychological therapies. This review examines the effectiveness of various psychotherapy approaches when added to medication for maintaining treatment in patients with bipolar disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Evidence-based research on the efficacy of psychologic interventions in bipolar disorders: a critical review.

Author: VietaEduard, PacchiarottiIsabella, ScottJan, Sánchez-MorenoJose, Di MarzoSylvia, ColomFrancesc

Improved bipolar disorder treatment
Increased treatment adherence
Reduced relapses
Bipolar disorder

While medication is the primary treatment for bipolar disorder, research shows that adding psychological interventions improves overall effectiveness, particularly in preventing relapses. Psychoeducation, family-focused therapy, and cognitive-behavioral therapy seem most beneficial for preventing recurrence in patients taking medication. These approaches are not equally effective for all patients and complement medication by improving symptoms and function. More research is needed to understand which elements of these psychological therapies are most helpful.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Differential efficacy of olanzapine and lithium in preventing manic or mixed recurrence in patients with bipolar I disorder based on number of previous manic or mixed episodes.

Author: KetterTerence A, HoustonJohn P, AdamsDavid H, RisserRichard C, MeyersAdam L, WilliamsonDouglas J, TohenMauricio

Improved bipolar disorder treatment
Reduced mood episodes
Bipolar disorder

Outcomes for bipolar disorder get worse as the number of manic episodes increases, highlighting the importance of preventing episodes early in the disease. This study examines the effectiveness of treatments in preventing mood episodes based on the number of previous manic episodes experienced by patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Topiramate for acute affective episodes in bipolar disorder.

Author: VasudevKamini, MacritchieKarine, GeddesJohn, WatsonStuart, YoungAllan

Improved bipolar disorder treatment
Bipolar disorder
Treatment resistance

Bipolar disorder is a common recurring illness that is often difficult to treat, even with standard medications like lithium and valproate. While initial studies suggest that the anticonvulsant topiramate might be helpful, more research is needed using controlled trials to confirm its effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Clinical features of bipolar depression versus major depressive disorder in large multicenter trials.

Author: PerlisRoy H, BrownEileen, BakerRobert W, NierenbergAndrew A

Improved diagnosis

Bipolar depression and major depressive disorder exhibit subtle differences in presentation, which may help guide the initial diagnosis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Psychotherapy for bipolar disorders - efficacy and effectiveness.

Author: ScottJan

Improved bipolar disorder treatment
Reduced relapses
Bipolar disorder

This paper explores the use of psychological therapies in addition to medication for bipolar disorder. Research shows that these combined approaches reduce relapses overall, but are particularly helpful for depression. While no specific therapy stands out as uniquely effective, more research is needed to identify which patients would benefit most from psychological interventions.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

Long-term effectiveness and cost of a systematic care program for bipolar disorder.

Author: SimonGregory E, LudmanEvette J, BauerMark S, UnützerJürgen, OperskalskiBelinda

Reduced mania symptoms

A multicomponent intervention program for bipolar disorder can significantly reduce the frequency and severity of mania, with modest cost increases. A randomized controlled trial of 441 patients showed that the intervention program reduced mean mania symptoms and time with significant mania symptoms. However, the intervention did not have a significant effect on depressive symptoms.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Pharmacological Treatment Patterns at Study Entry for the First 500 STEP-BD Participants.

Author: GhaemiS Nassir, HsuDouglas J, ThaseMichael E, WisniewskiStephen R, NierenbergAndrew A, MiyaharaSachiko, SachsGary

Improved bipolar disorder management

Patients with bipolar disorder are primarily treated with standard mood stabilizers, followed by moderate use of antidepressants, novel anticonvulsants, and second-generation neuroleptics. A cross-sectional analysis of 500 patients with bipolar disorder found that standard mood stabilizers were the most commonly prescribed drug class. These prescribing patterns highlight the current clinical standard of care and areas where further research is needed.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

30.

A meta-analysis of relapse rates with adjunctive psychological therapies compared to usual psychiatric treatment for bipolar disorders.

Author: ScottJan, ColomFrancesc, VietaEduard

Reduced bipolar disorder relapse
Bipolar disorder

This review found that adding psychological therapies to standard treatment for bipolar disorder significantly reduces the risk of relapses (about 40% reduction). These therapies were most effective for people who were well at the start of treatment and might be less effective for those with a history of many episodes. While research shows these therapies are effective, more studies are needed to determine who benefits most from them.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

31.

Tiagabine in the treatment of acute affective episodes in bipolar disorder: efficacy and acceptability.

Author: YoungA H, GeddesJ R, MacritchieK, RaoS N K, WatsonS, VasudevA

Improved bipolar disorder treatment
Bipolar disorder

Bipolar disorder is a common condition that often returns, and it can be hard to treat, even with standard medications. While some preliminary studies suggest that the anticonvulsant tiagabine might be helpful, more research is needed using controlled trials to confirm its effectiveness for treating acute episodes of bipolar disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

Patients' expectancies, the alliance in pharmacotherapy, and treatment outcomes in bipolar disorder.

Author: GaudianoBrandon A, MillerIvan W

Improved bipolar disorder treatment
Bipolar disorder

Bipolar disorder is a chronic condition with recurring episodes. Many patients stop taking their medication, but the reasons for this are not well understood. This study found that patients' expectations for improvement and the relationship between the patient and their doctor were important factors in how long they stayed on medication for bipolar disorder. This suggests that addressing these factors could improve treatment outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

33.

Efficacy of psychoeducational approaches on bipolar disorders: a review of the literature.

Author: RougetBéatrice Weber, AubryJean-Michel

Improved bipolar disorder treatment
Increased treatment compliance
Bipolar disorder

This study examines the effectiveness of psychoeducation in treating bipolar disorder, specifically looking at how it impacts treatment adherence, patients' and families' understanding of the illness and treatment, relapse prevention, managing depressive or manic phases, and social and work functioning.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

The armamentarium of treatments for bipolar disorder: a review of the literature.

Author: CousinsDavid A, YoungAllan H

Improved bipolar disorder treatment
Bipolar disorder

This review found that lithium and valproate are the most commonly used medications for bipolar disorder, but they have limitations in terms of side effects and effectiveness in certain groups. Newer anticonvulsants, especially lamotrigine, have shown promise for managing different bipolar symptoms. Antidepressants are generally not used alone for bipolar depression or schizoaffective disorder due to the risk of triggering manic episodes, but they may be helpful with atypical antipsychotics. Atypical antipsychotics can also be used alone or with mood stabilizers for managing manic episodes and for long-term treatment. The choice of antipsychotic depends on the situation, with fast-acting medications used for acute episodes and those that are easier to take long-term used for maintenance. This review suggests a growing role for atypical antipsychotics in bipolar disorder treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

35.

Interventions for helping people recognise early signs of recurrence in bipolar disorder.

Author: MorrissR K, FaizalM A, JonesA P, WilliamsonP R, BoltonC, McCarthyJ P

Improved bipolar disorder treatment
Reduced bipolar episodes
Bipolar disorder

Despite effective medications, bipolar disorder frequently returns. Self-help and psychological treatments that teach patients to identify and manage early warning signs of mood episodes are popular. The goal is to intervene early and prevent episodes, extending the time until the next recurrence and reducing hospitalizations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

36.

Effectiveness of adjunctive antidepressant treatment for bipolar depression.

Author: SachsGary S, NierenbergAndrew A, CalabreseJoseph R, MarangellLauren B, WisniewskiStephen R, GyulaiLaszlo, FriedmanEdward S, BowdenCharles L, FosseyMark D, OstacherMichael J, KetterTerence A, PatelJayendra, HauserPeter, RapportDaniel, MartinezJames M, AllenMichael H, MiklowitzDavid J, OttoMichael W, DennehyEllen B, ThaseMichael E

Improved bipolar depression treatment
Bipolar depression

Depressive episodes are the most common reason for disability in people with bipolar disorder. The effectiveness and safety of typical antidepressants for treating depression in bipolar disorder haven't been well studied. This study examines whether adding antidepressants to standard bipolar treatment reduces depressive symptoms without increasing the risk of manic episodes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

37.

How well do psychosocial interventions work in bipolar disorder?

Author: ZaretskyAri E, RizviSakina, ParikhSagar V

Relapse prevention
Symptom treatment

Various manualized psychosocial interventions have been shown to be beneficial for patients with bipolar disorder, particularly in the areas of relapse prevention and symptom management. This systematic review of the recent literature highlights cognitive-behavioral therapy, family-focused therapy, and psychoeducation as particularly effective interventions for relapse prevention, while interpersonal therapy and cognitive-behavioral therapy may be more beneficial for treating residual depressive symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Weight gain and metabolic effects of mood stabilizers and antipsychotics in pediatric bipolar disorder: a systematic review and pooled analysis of short-term trials.

Author: CorrellChristoph U

Weight gain

Combining antipsychotics with mood stabilizers seems to lead to greater weight gain than treatment with one or two mood stabilizers in pediatric bipolar disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

39.

Effectiveness of mood stabilizers and antipsychotics in the maintenance phase of bipolar disorder: a systematic review of randomized controlled trials.

Author: SmithLesley A, CorneliusVictoria, WarnockAdrian, BellAngus, YoungAllan H

Reduced relapse
Adverse events

Mood stabilizers like lithium, lamotrigine, olanzapine, and valproate semisodium have differing profiles of efficacy and tolerability, suggesting complementary roles in long-term maintenance treatment for bipolar disorder. Lithium and olanzapine were more effective in preventing manic relapses, while lamotrigine and valproate semisodium were more effective in preventing depressive relapses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

40.

[Psychotherapy for bipolar disorder : a systematic review of controlled studies].

Author: HautzingerM, MeyerT D

Improved bipolar affective disorder treatment
Bipolar affective disorder

While mood stabilizers help prevent relapses in bipolar disorder, most patients still experience them despite medication. Adding psychological therapies, which focus on education about the illness, symptom monitoring, and coping strategies, seems promising. A review of studies found that psychotherapy, combined with mood stabilizers, improved depressive symptoms (though less so for manic symptoms) and nearly doubled the time between episodes. More research is needed on who benefits most, how long treatment should last, key elements of successful therapy, long-term follow-up, and preventing bipolar disorder in high-risk groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : German

41.

Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trial.

Author: MiklowitzDavid J, OttoMichael W, FrankEllen, Reilly-HarringtonNoreen A, KoganJane N, SachsGary S, ThaseMichael E, CalabreseJoseph R, MarangellLauren B, OstacherMichael J, PatelJayendra, ThomasMarshall R, AragaMako, GonzalezJodi M, WisniewskiStephen R

Improved bipolar disorder treatment
Bipolar disorder

Psychological treatments are helpful additions to medication for preventing bipolar disorder relapses. This study investigates the impact of intensive psychological treatment combined with medication on how well people with bipolar disorder function in their daily lives over nine months following a depressive episode.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

42.

Mindfulness-based Cognitive Therapy (MBCT) in bipolar disorder: preliminary evaluation of immediate effects on between-episode functioning.

Author: WilliamsJ M G, AlatiqY, CraneC, BarnhoferT, FennellM J V, DugganD S, HepburnS, GoodwinG M

Improved bipolar disorder treatment
Bipolar disorder

Bipolar disorder often recurs, and people with bipolar disorder frequently have other mental health conditions. Anxiety is linked to a higher risk of suicide attempts and poor outcomes in bipolar disorder. This study investigates the feasibility and potential benefits of a new psychological treatment called Mindfulness-based Cognitive Therapy (MBCT) for people with bipolar disorder, focusing on anxiety and depressive symptoms that occur between episodes of mania or depression.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

43.

Family interventions for bipolar disorder.

Author: JustoL P, SoaresB G O, CalilH M

Improved bipolar disorder treatment
Bipolar disorder

While medications are the main treatment for bipolar disorder, adding psychological interventions can improve outcomes. Family therapy is particularly important because it can reduce the burden on family members and caregivers, making it easier to support the patient.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Lithium in mood disorders: increasing evidence base, declining use?

Author: YoungAllan H, HammondJudith M

Improved bipolar disorder treatment
Bipolar disorder

While knowledge about the benefits and side effects of lithium for treating bipolar disorder has increased, its use may be declining. Recent reviews confirm that lithium is effective for long-term treatment and reduces the risk of suicide. Psychiatrists should continue to use this effective treatment for bipolar disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

45.

Impact of remitted substance use disorders on the future course of bipolar I disorder: findings from a clinical trial.

Author: GaudianoBrandon A, UebelackerLisa A, MillerIvan W

Improved bipolar I disorder treatment
Bipolar I disorder

This study found that people with bipolar disorder who had recently stopped abusing substances had poorer treatment outcomes compared to those without this history. They took longer to recover from their current episode and experienced more depressive and manic symptoms over time. While further substance abuse during the study could partially explain this, the results suggest that a past history of substance abuse negatively predicts treatment outcomes. This has implications for both research and clinical practice for bipolar disorder.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

46.

Pharmacological interventions for the prevention of relapse in bipolar disorder: a systematic review of controlled trials.

Author: BeynonS, Soares-WeiserK, WoolacottN, DuffyS, GeddesJ R

Improved bipolar disorder treatment
Bipolar disorder

This review of 34 studies on preventing bipolar disorder relapses found that lithium, valproate, and lamotrigine were effective in preventing relapses. Lithium, olanzapine, and aripiprazole were effective in preventing manic episodes, while valproate, lamotrigine, and imipramine were effective in preventing depressive symptoms. Imipramine is not commonly used due to side effects. Although widely used, combination therapy lacks strong evidence for effectiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

47.

Treatment of bipolar disorder: a systematic review of available data and clinical perspectives.

Author: FountoulakisKonstantinos N, VietaEduard

Improved bipolar disorder treatment
Bipolar disorder

This review of research on bipolar disorder found that lithium is effective for both acute manic episodes and long-term management. First- and second-generation antipsychotics are effective for acute mania. Quetiapine and a combination of olanzapine and fluoxetine are effective for treating bipolar depression, while olanzapine, quetiapine, and aripiprazole are useful for long-term management. Anticonvulsants, particularly valproate and carbamazepine, help with mania, while lamotrigine might be more effective for depression. Antidepressants should always be used with other medications due to the risk of triggering manic episodes. The best psychological treatments are group and family psychoeducation. Electroconvulsive therapy can be used for patients who don't respond to other treatments. While many treatment options exist, they are not consistently effective, especially for depression and long-term management. Combining treatments may improve outcomes, but it can increase side effects. Further research is needed to develop more effective treatments and better guidelines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

48.

Randomized, placebo-controlled trial of risperidone for acute treatment of bipolar anxiety.

Author: SheehanDavid V, McElroySusan L, Harnett-SheehanKathy, KeckPaul E, JanavsJuris, RogersJamison, GonzalezRobert, ShivakumarGeetha, SuppesTrisha

None specified
None specified

Risperidone monotherapy was not an effective anxiolytic for bipolar patients with comorbid panic disorder or generalized anxiety disorder (GAD) in doses of 0.5-4 mg/day over 8 weeks of treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

49.

Olanzapine in long-term treatment for bipolar disorder.

Author: CiprianiAndrea, RendellJennifer M, GeddesJohn

Improved manic symptoms
Prevents relapses
Depression
Weight gain

Olanzapine may prevent further mood episodes in patients who have responded to olanzapine during an index manic or mixed episode and who have not previously had a satisfactory response to lithium or valproate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

Enhancing outcomes in patients with bipolar disorder: results from the Bipolar Disorder Center for Pennsylvanians Study.

Author: FagioliniAndrea, FrankEllen, AxelsonDavid A, BirmaherBoris, ChengYu, CuretDavid E, FriedmanEdward S, GildengersAriel G, GoldsteinTina, GrochocinskiVictoria J, HouckPatricia R, StofkoMary G, ThaseMichael E, ThompsonWesley K, TurkinScott R, KupferDavid J

Bipolar disorder treatment

This study investigates whether specialized care for bipolar disorder (SCBD) and a combined approach of enhanced clinical intervention (ECI) plus SCBD can improve outcomes and reduce health disparities for young and older adults, African Americans, and people in rural areas with bipolar disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

51.

What happens after diagnosis? Understanding the experiences of patients with newly-diagnosed bipolar disorder.

Author: ProudfootJudith G, ParkerGordon B, BenoitMegan, ManicavasagarVijaya, SmithMeg, GayedAimee

Bipolar disorder treatment

Bipolar disorder is a chronic condition with periods of both depression and high mood, which can lead to significant disability and a high risk of episodes returning. This condition affects about 5% of people over their lifetime. There is limited understanding of how people feel after being diagnosed with bipolar disorder and how these feelings influence their willingness and ability to work with healthcare professionals to find the best treatment and manage their condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

52.

The factor structure of clinical symptoms in mixed and manic episodes prior to and after antipsychotic treatment.

Author: HarveyPhilip D, EndicottJean M, LoebelAntony D

Bipolar disorder treatment

While research has examined how symptoms of schizophrenia are organized, there is less information on how symptoms of bipolar disorder are structured. This study investigated the pattern of symptoms in bipolar disorder before treatment and after treatment with either ziprasidone, haloperidol, or a placebo. The study expected that the pattern of symptoms after treatment would be similar to the pattern of symptoms before treatment, which is consistent with findings in schizophrenia research.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

53.

The impact of staging bipolar disorder on treatment outcome of family psychoeducation.

Author: ReinaresMaría, ColomFrancesc, RosaAdriane R, BonnínC Mar, FrancoCarolina, SoléBrisa, KapczinskiFlavio, VietaEduard

Bipolar disorder treatment

While psychological treatment can improve outcomes for bipolar disorder, it's unclear what factors influence its effectiveness. This study examines whether the stage of bipolar disorder (ranging from early warning signs to more severe and treatment-resistant stages) is linked to how well caregivers respond to psychoeducation.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

54.

Divalproex sodium versus placebo in the treatment of acute bipolar depression: a systematic review and meta-analysis.

Author: BondDavid J, LamRaymond W, YathamLakshmi N

BD treatment

Bipolar disorder is characterized by periods of both high mood and depression, with depression being more common and causing significant disability. Divalproex is a commonly prescribed medication for bipolar disorder. While some evidence suggests that divalproex can prevent depressive episodes in the long-term, it is not often used to treat acute depression, as there is a perception that it is not very effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

55.

The study protocol of the Norwegian randomized controlled trial of electroconvulsive therapy in treatment resistant depression in bipolar disorder.

Author: KesslerUte, VaalerArne E, SchøyenHelle, OedegaardKetil J, BergsholmPer, AndreassenOle A, MaltUlrik F, MorkenGunnar

Bipolar depression treatment
Cognitive side effects

Treating depression in bipolar disorder is challenging. The effectiveness of commonly used antidepressants for this condition is unclear. While electroconvulsive therapy is considered the most effective treatment, there are no controlled studies on its use for bipolar depression. While electroconvulsive therapy is generally safe, its effects on cognition are debated. This study aims to compare the effectiveness and side effects of electroconvulsive therapy to medication for treatment-resistant bipolar depression, assessing changes in thinking and quality of life during treatment.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

56.

Efficacy and acceptability of mood stabilisers in the treatment of acute bipolar depression: systematic review.

Author: Van LieshoutRyan J, MacQueenGlenda M

Increased remission rates
Increased response rates
Suicide
Switching
Weight gain

This meta-analysis examined the efficacy and safety of mood stabilizers for acute bipolar depression. Eighteen studies with 4105 participants were included. Mood stabilizers were more effective than placebo in achieving response and remission. Combination therapy was not statistically superior to monotherapy. Further research on mood stabilizers is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

57.

Asenapine for long-term treatment of bipolar disorder: a double-blind 40-week extension study.

Author: McIntyreRoger S, CohenMiriam, ZhaoJun, AlphsLarry, MacekThomas A, PanagidesJohn

Improved manic symptoms
Long-term efficacy
Side effects

In this 52-week extension in patients with bipolar mania, asenapine was well tolerated and long-term maintenance of efficacy was supported.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

58.

New treatment guidelines for acute bipolar depression: a systematic review.

Author: NivoliAlessandra M A, ColomFrancesc, MurruAndrea, PacchiarottiIsabella, Castro-LoliPiero, González-PintoAna, FountoulakisKostas N, VietaEduard

Bipolar depression treatment

Bipolar depression is a significant challenge for patients and their families due to its duration, impact on function, and limited treatment options. To standardize treatment, several guidelines, recommendations, and expert opinions have been developed, but often have conflicting conclusions due to limited research. Since new research is being published, these guidelines need to be regularly updated. Many guidelines for bipolar disorder (BD) treatment have been updated in recent years.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

59.

LICAVAL: combination therapy in acute and maintenance treatment of bipolar disorder.

Author: CamposRodolfo N, CostaLuis F, BioDanielle S, Soeiro de SouzaMárcio G, GarciaCarla R L, DemétrioFrederico N, MorenoDoris H, MorenoRicardo A

BD treatment

Treating bipolar disorder is challenging due to the complex nature of the illness. Current guidelines aim to help doctors, but have limitations, particularly for long-term treatment. This LICAVAL study will examine the effectiveness and tolerability of combining lithium with either carbamazepine or valproic acid to treat bipolar disorder in young people, looking at both acute and long-term treatment phases.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

60.

Association between bipolar spectrum features and treatment outcomes in outpatients with major depressive disorder.

Author: PerlisRoy H, UherRudolf, OstacherMichael, GoldbergJoseph F, TrivediMadhukar H, RushA John, FavaMaurizio

Poorer treatment outcomes

This study found that self-reported psychotic-like symptoms were common in patients with major depressive disorder (MDD) and were associated with poorer treatment outcomes. The study also found that irritability and psychotic-like symptoms at entry were associated with poorer outcomes across up to 4 treatment levels.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

61.

Clinical management and burden of bipolar disorder: a multinational longitudinal study (WAVE-bd study).

Author: VietaEduard, Blasco-ColmenaresElena, FigueiraMaria Luisa, LangoschJens M, Moreno-ManzanaroMiriam, MedinaEsteban,

BD treatment

Most research on bipolar disorder (BD) has focused on a single phase of the illness or a specific treatment, limiting our understanding of the overall disease. This study, called WAVE-bd, aims to gather information about how BD is managed in everyday clinical settings. It will track patients with both type I and type II BD over time, looking at factors that influence treatment outcomes and the use of resources.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

62.

Effectiveness of psychotropic medications in the maintenance phase of bipolar disorder: a meta-analysis of randomized controlled trials.

Author: VietaEduard, GüntherOliver, LocklearJulie, EkmanMattias, MiltenburgerCarolin, ChattertonMary Lou, ÅströmMikael, PaulssonBjörn

Bipolar disorder treatment

This meta-analysis of 20 studies found that lithium and quetiapine were the most commonly studied treatments for preventing bipolar disorder relapses. Most treatments, except for a combination of perphenazine and a mood stabilizer, were associated with a reduced risk of relapses compared to placebo. No single medication significantly reduced both manic and depressive relapses. Combining quetiapine with lithium or divalproex significantly reduced both manic and depressive relapses compared to placebo. The study highlights the variable effectiveness of different treatments and the importance of considering both efficacy and safety when choosing a medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

63.

Extended-release quetiapine as monotherapy for the treatment of adults with acute mania: a randomized, double-blind, 3-week trial.

Author: CutlerAndrew J, DattoCatherine, NordenhemArvid, MinkwitzMargaret, AcevedoLarisa, DarkoDenis

Treatment of bipolar disorder

Bipolar disorder is a recurring and long-lasting condition that often requires hospitalization and lifelong medication. It involves periods of both mania and depression. Due to the severity of manic episodes, doctors need to be able to manage symptoms quickly.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

65.

An online randomised controlled trial to assess the feasibility, acceptability and potential effectiveness of 'Living with Bipolar': a web-based self-management intervention for bipolar disorder: trial design and protocol.

Author: ToddNicholas J, Solis-TrapalaIvonne, JonesSteven H, LobbanFiona A

Treatment of bipolar disorder

Bipolar Disorder (BD) is a serious mental illness that affects many people. While medication is the most common treatment, it's not always very effective. Research shows that people with BD often benefit from psychological therapies. However, access to these therapies can be limited, leading many to seek support outside of traditional healthcare settings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

66.

Efficacy of pharmacotherapy in bipolar disorder: a report by the WPA section on pharmacopsychiatry.

Author: FountoulakisKonstantinos N, KasperSiegfried, AndreassenOle, BlierPierre, OkashaAhmed, SeverusEmanuel, VersianiMarcio, TandonRajiv, MöllerHans-Jürgen, VietaEduard

Treatment of bipolar disorder
Side effects

This review examines medications used to treat bipolar disorder (BP). Lithium, antipsychotics (first and second generation), valproate, and carbamazepine are effective for acute manic episodes. Quetiapine and a combination of olanzapine and fluoxetine are effective for treating depression in bipolar disorder. Antidepressants should only be used with mood stabilizers, as they can worsen manic symptoms if used alone. Lithium, olanzapine, quetiapine, and aripiprazole are helpful in preventing future episodes. Lamotrigine is effective in preventing depressive episodes, but its use for mania is still being studied. Combination therapy can be effective but can also increase the risk of side effects. More research is needed to develop better treatment guidelines and algorithms for managing bipolar disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

67.

A randomized controlled trial of psychoeducation or cognitive-behavioral therapy in bipolar disorder: a Canadian Network for Mood and Anxiety treatments (CANMAT) study [CME].

Author: ParikhSagar V, ZaretskyAri, BeaulieuSerge, YathamLakshmi N, YoungL Trevor, Patelis-SiotisIrene, MacqueenGlenda M, LevittAnthony, ArenovichTamara, CervantesPablo, VelyvisVytas, KennedySidney H, StreinerDavid L

Treatment of bipolar disorder

While medication is often used for bipolar disorder, additional therapies are often needed. This study compares two types of therapy: a short group therapy session focused on education and a longer, individual therapy program based on cognitive-behavioral therapy. The study aims to determine which type of therapy is more effective in managing mood symptoms over time.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

68.

Treatment moderators and predictors of outcome in the Treatment of Early Age Mania (TEAM) study.

Author: VitielloBenedetto, RiddleMark A, YenokyanGayane, AxelsonDavid A, WagnerKaren D, JoshiParamjit, WalkupJohn T, LubyJoan, BirmaherBoris, RyanNeal D, EmslieGraham, RobbAdelaide, TillmanRebecca

Treatment of bipolar mania

Treating bipolar disorder in children is challenging. In a study called TEAM, the medication risperidone was more effective than lithium or divalproex in children with bipolar mania, especially those with attention-deficit/hyperactivity disorder (ADHD). This research aims to identify factors that might predict how well children respond to treatment and what might make treatment more effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

69.

Randomized, placebo-controlled trial of quetiapine XR and divalproex ER monotherapies in the treatment of the anxious bipolar patient.

Author: SheehanDavid V, Harnett-SheehanKathy, HidalgoRosario B, JanavsJuris, McElroySusan L, AmadoDarlene, SuppesTrisha

Reduced anxiety
Weight gain

Quetiapine XR was found to effectively reduce anxiety in patients with bipolar disorder and comorbid panic disorder or generalized anxiety disorder, compared to divalproex ER and placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

70.

Antidepressant-associated mood-switching and transition from unipolar major depression to bipolar disorder: a review.

Author: BaldessariniRoss J, FaeddaGianni L, OffidaniEmanuela, VázquezGustavo H, MarangoniCiro, SerraGiulia, TondoLeonardo

Antidepressant mood switching
BPD diagnosis

This review analyzed reports of patients diagnosed with MDD and treated with an AD. The overall risk of mood-switching was 8.18%. The risk was 2.6 times greater with AD-treatment compared to without AD-treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

71.

Tiagabine for acute affective episodes in bipolar disorder.

Author: VasudevAkshya, MacritchieKarine, RaoSanjay K, GeddesJohn, YoungAllan H

Treatment resistance

Bipolar disorder is a common and often recurring condition that can be difficult to control with medication. While traditional medications like lithium and valproate are used, there is a need for new treatments for those who don't respond well. Some reports suggest that the anticonvulsant medication tiagabine might be effective for bipolar disorder, but more research is needed through controlled studies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

72.

Efficacy of aripiprazole versus placebo as adjuncts to lithium or valproate in relapse prevention of manic or mixed episodes in bipolar I patients stratified by index manic or mixed episode.

Author: YathamLakshmi N, FountoulakisKonstantinos N, RahmanZia, AmmermanDiane, FyansPaula, MarlerSabrina V, BakerRoss A, CarlsonBerit X

Bipolar disorder treatment

People with bipolar disorder who experience manic or mixed episodes (both mania and depression) may respond differently to treatment. This study looks at how effective the medication aripiprazole is in preventing relapses in people with bipolar disorder who had either manic or mixed episodes, when combined with either lithium or valproate.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

73.

Overview of antidepressant treatment of bipolar depression.

Author: VázquezGustavo H, TondoLeonardo, UndurragaJuan, BaldessariniRoss J

Bipolar depression treatment
Mood-switching

Treating depression in people with bipolar disorder is a challenge. Despite available medications, many people with bipolar disorder spend half their time experiencing depression or other mood problems. There's limited and inconsistent evidence on how well standard treatments, particularly antidepressants, work for this type of depression. While research on antidepressants for bipolar depression is limited, a review suggests that they are more effective than placebos and not less effective than in people with depression who don't have bipolar disorder. The risk of antidepressants causing mood switches (from depression to mania) may be less than previously thought. More research is needed on antidepressants for bipolar depression, including examining different types of bipolar disorder and how best to treat mixed states.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

74.

Post-acute effectiveness of lithium in pediatric bipolar I disorder.

Author: FindlingRobert L, KafantarisVivian, PavuluriMani, McNamaraNora K, FrazierJean A, SikichLinmarie, KowatchRobert, RowlesBrieana M, ClemonsTraci E, Taylor-ZapataPerdita

Mood stabilization
Abdominal pain
Headache
Tremor
Vomiting

The study examined the long-term effectiveness of lithium for pediatric bipolar disorder. Patients who initially responded to lithium maintained mood stabilization during continuation treatment. Partial responders did not experience further improvement, despite the possibility of receiving adjunctive medications.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

75.

Is the combination of a mood stabilizer plus an antipsychotic more effective than mono-therapies in long-term treatment of bipolar disorder? A systematic review.

Author: BuoliMassimiliano, SeratiMarta, AltamuraA Carlo

BD treatment

The goal of long-term treatment for bipolar disorder is to prevent relapses, which can worsen cognitive function and make the condition more difficult to manage. While mood stabilizers are often used, about 40% of people with bipolar disorder still experience relapses. This review examines the effectiveness and safety of combining mood stabilizers with antipsychotic medications.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

76.

Do comorbid anxiety disorders moderate the effects of psychotherapy for bipolar disorder? Results from STEP-BD.

Author: DeckersbachThilo, PetersAmy T, SylviaLouisa, UrdahlAnna, MagalhãesPedro V S, OttoMichael W, FrankEllen, MiklowitzDavid J, BerkMichael, KinrysGustavo, NierenbergAndrew

Bipolar disorder treatment

Anxiety disorders are common in people with bipolar disorder, making the condition more severe and difficult to treat. This study examines whether the presence of anxiety affects how well people with bipolar disorder respond to psychotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

77.

Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder.

Author: CiprianiAndrea, ReidKeith, YoungAllan H, MacritchieKarine, GeddesJohn

Bipolar disorder treatment

Bipolar disorder is a recurring mental illness that ranks among the top 30 causes of disability globally. Treatment focuses on preventing episodes and minimizing side effects. While lithium is often used, it doesn't work well for 20-40% of people. Valproate, an anticonvulsant drug, is also used and can help manage manic episodes. When choosing long-term treatment, effectiveness and side effects are important considerations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

78.

Aripiprazole alone or in combination for acute mania.

Author: BrownRachel, TaylorMatthew J, GeddesJohn

Bipolar disorder treatment

Bipolar disorder is a mental health condition characterized by mood swings. Medication is the primary treatment for manic episodes, focusing on quickly controlling agitation and risky behavior. Aripiprazole, an antipsychotic medication, is used alone or with other medications to treat mania. Studies have shown that aripiprazole and other atypical antipsychotics are effective in treating manic episodes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

79.

Efficacy of olanzapine monotherapy for treatment of bipolar I depression: a randomized, double-blind, placebo controlled study.

Author: WangMan, TongJian-hua, HuangDe-sheng, ZhuGang, LiangGuang-ming, DuHong

Bipolar depression treatment

Depression is the main cause of disability for people with bipolar disorder. While treatments for depression in bipolar disorder are often based on experience, not strong evidence, this study investigates the effectiveness of olanzapine, an antipsychotic medication, used alone to treat depression in people with bipolar I disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

80.

Effects of celecoxib on inflammatory markers in bipolar patients undergoing electroconvulsive therapy: a placebo-controlled, double-blind, randomised study.

Author: KargarMona, YousefiAbolghasem, MojtahedzadehMojtaba, AkhondzadehShahin, ArtounianValentin, AbdollahiAlireza, AhmadvandAlireza, GhaeliPadideh

Reduced TNF-α

Celecoxib was found to significantly reduce TNF-α levels in patients with bipolar disorder undergoing electroconvulsive therapy (ECT).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

81.

Pharmacotherapy and family-focused treatment for adolescents with bipolar I and II disorders: a 2-year randomized trial.

Author: MiklowitzDavid J, SchneckChristopher D, GeorgeElizabeth L, TaylorDawn O, SugarCatherine A, BirmaherBoris, KowatchRobert A, DelBelloMelissa P, AxelsonDavid A

Bipolar disorder treatment

Previous research has shown that family therapy can help manage bipolar disorder in adults. This study examines whether adding family therapy to medication for adolescents with bipolar disorder is more effective than medication plus brief education in reducing the time to recover from a mood episode, preventing relapses, and lessening symptom severity over two years.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

82.

The addition of STEPPS in the treatment of patients with bipolar disorder and comorbid borderline personality features: a protocol for a randomized controlled trial.

Author: RiemannGeorg, WeisscherNadine, GoossensPeter J J, DraijerNel, Apenhorst-HolMarjolein, KupkaRalph W

BD and BPD treatment

Bipolar disorder (BD) and borderline personality disorder (BPD) are both serious and long-lasting mental health conditions that share some symptoms. Having BPD makes bipolar disorder more challenging to manage. Research shows that people with both conditions experience a more difficult course of illness, poorer response to medication, longer treatment, more hospitalizations, a higher risk of substance abuse and suicide, and greater difficulty with work and relationships. However, there is no research on specific therapy for these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

83.

Treatment of comorbid bipolar disorder and obsessive-compulsive disorder: a systematic review.

Author: AmerioA, OdoneA, MarchesiC, GhaemiS N

BD-OCD treatment

More than 20% of people with bipolar disorder (BD) also have obsessive-compulsive disorder (OCD), making treatment challenging. While medications called serotonin reuptake inhibitors (SSRIs) are the usual treatment for OCD, they can worsen mood swings in BD. The best way to treat both conditions together is still being determined.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

84.

Safety and tolerability of antipsychotic-mood stabilizer co-treatment in the management of acute bipolar disorder: results from a systematic review and exploratory meta-analysis.

Author: GallingBritta, GarciaMaryam A, OsuchukwuUzoma, HagiKatsuhiko, CorrellChristoph U

Improved bipolar disorder symptoms
Extrapyramidal symptoms
Glucose and lipid abnormalities
Weight gain

This systematic review evaluated the adverse effects of mood stabilizer (MS) plus antipsychotic (AP) co-treatment in patients with acute bipolar disorder (BD). The study found that MS+AP co-treatment was associated with a significantly higher burden of adverse effects, particularly weight gain, extrapyramidal symptoms, and glucose/lipid-related adverse effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

85.

Lithium in the Acute Treatment of Bipolar I Disorder: A Double-Blind, Placebo-Controlled Study.

Author: FindlingRobert L, RobbAdelaide, McNamaraNora K, PavuluriMani N, KafantarisVivian, SchefferRussell, FrazierJean A, RynnMoira, DelBelloMelissa, KowatchRobert A, RowlesBrieana M, LinglerJacqui, MartzKaren, AnandRavinder, ClemonsTraci E, Taylor-ZapataPerdita

No weight gain
Reduced manic symptoms
Well tolerated
Thyrotropin increase

This study found that lithium was superior to placebo in reducing manic symptoms in children with bipolar disorder type 1. Lithium was well tolerated and did not cause weight gain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

86.

Medical burden, body mass index and the outcome of psychosocial interventions for bipolar depression.

Author: PetersAmy T, SheslerLeah W, SylviaLouisa, da Silva MagalhaesPedro Vieira, MiklowitzDavid J, OttoMichael W, FrankEllen, BerkMichael, DoughertyDarin D, NierenbergAndrew A, DeckersbachThilo

Bipolar disorder treatment

People with bipolar disorder often have other health problems and obesity, which can make it harder to recover from mood episodes and respond to medications. This study examines whether these factors affect how well people with bipolar disorder respond to therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

87.

A systematic review of cognitive rehabilitation for bipolar disorder.

Author: Kluwe-SchiavonBruno, ViolaThiago Wendt, LevandowskiMateus Luz, BortolottoVanessa Rezende, Azevedo e SouzaLeo Schuch, TractenbergSaulo Gantes, SoaresTárcio

BD treatment

Bipolar disorder affects cognitive function and behavior. This research examines cognitive enhancement programs as potential treatments for bipolar disorder, focusing on improving thinking skills and daily functioning rather than traditional approaches that focus on education and coping strategies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

88.

[Pharmacological treatment of bipolar disorder in children and adolescents].

Author: BaillyD

Effective manic episode treatment
Gastrointestinal issues
Neurological issues
Sedation
Weight gain

Antipsychotics are more effective than mood stabilizers in treating manic or mixed episodes in children and adolescents with bipolar disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

89.

A Systematic Review and Critical Appraisal of Economic Evaluations of Pharmacological Interventions for People with Bipolar Disorder.

Author: MavranezouliIfigeneia, LokkerbolJoran

BD treatment

Bipolar disorder (BD) is a serious mental health condition with significant emotional and financial impacts. While medications are effective for managing and preventing severe episodes of BD, there's growing interest in evaluating the cost-effectiveness of different treatments, especially with limited healthcare budgets.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

90.

Online psycho-education to the treatment of bipolar disorder: protocol of a randomized controlled trial.

Author: González-OrtegaItxaso, UgarteAmaia, Ruiz de AzúaSonia, NúñezNuria, ZubiaMarta, PonceSara, CaslaPatricia, LlanoJosu Xabier, FariaÁngel, González-PintoAna

Bipolar disorder treatment

Bipolar disorder is characterized by recurring episodes and ongoing challenges like cognitive problems and difficulties with daily life, leading to a reduced quality of life, relapses, and hospitalizations. Early diagnosis and treatment are important. While online interventions offer a convenient way to access therapy, there is a lack of solid evidence about their effectiveness due to inconsistent research methods.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

91.

Safety and efficacy of adjunctive second-generation antidepressant therapy with a mood stabiliser or an atypical antipsychotic in acute bipolar depression: a systematic review and meta-analysis of randomised placebo-controlled trials.

Author: McGirrAlexander, VöhringerPaul A, GhaemiS Nassir, LamRaymond W, YathamLakshmi N

Reduced bipolar depression
Mania/hypomania risk

This systematic review and meta-analysis examined the efficacy and safety of second-generation antidepressants adjunctive to a mood stabilizer or an antipsychotic in patients with acute bipolar depression. The review found that second-generation antidepressants were associated with a small but significant improvement in clinician-rated depressive symptom score. However, they did not increase clinical response or remission rates. Prolonged use was associated with an increased risk of treatment-emergent mania or hypomania.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

92.

Psychosocial therapies for the adjunctive treatment of bipolar disorder in adults: network meta-analysis.

Author: ChattertonMary Lou, StockingsEmily, BerkMichael, BarendregtJan J, CarterRob, MihalopoulosCathrine

Bipolar disorder treatment

This study compared different types of psychological therapies for bipolar disorder. Family-focused interventions reduced the risk of relapses into manic or depressive episodes. Psychoeducation alone or combined with cognitive-behavioral therapy (CBT) decreased medication non-adherence. Psychoeducation plus CBT improved manic symptoms and overall functioning. None of the therapies significantly reduced depressive symptoms, suggesting a need for new approaches to treat depression in bipolar disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

93.

Cognitive-behavioral rehabilitation vs. treatment as usual for bipolar patients: study protocol for a randomized controlled trial.

Author: GomesBernardo Carramão, RoccaCristiana Castanho, BelizarioGabriel Okawa, LaferBeny

Bipolar disorder treatment

People with bipolar disorder often experience cognitive and functional problems, even when they're not having episodes. While therapy can help, it's less effective for severe cases. New interventions designed to improve thinking skills in bipolar disorder have had mixed results.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

94.

Efficacy of cognitive-behavioral therapy in patients with bipolar disorder: A meta-analysis of randomized controlled trials.

Author: ChiangKai-Jo, TsaiJui-Chen, LiuDoresses, LinChueh-Ho, ChiuHuei-Ling, ChouKuei-Ru

Bipolar disorder treatment

Cognitive behavioral therapy (CBT) is considered a potentially helpful addition to medication for bipolar disorder (BD), but its effectiveness hasn't been definitively proven. This review examined studies comparing CBT combined with medication to standard care alone for BD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

95.

A meta-analysis of adjuvant group-interventions in psychiatric care for patients with bipolar disorders.

Author: MacheinerTanja, SkavantzosAndreas, PilzRené, ReininghausEva Z

Bipolar disorder treatment

Bipolar disorder is a major cause of disability and high healthcare costs. Combining mood-stabilizing medications with therapy has been shown to reduce relapses and hospitalizations. However, there are many different types of psychological interventions, and more research is needed to determine which are most effective.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

96.

The feasibility and acceptability of a novel anxiety in bipolar disorder intervention compared to treatment as usual: A randomized controlled trial.

Author: JonesSteven H, KnowlesDawn, TylerElizabeth, HollandFiona, PetersSarah, LobbanFiona, LangshawBrian, HiltonClaire, LongRita, GanttKay, OwenRebecca, RobertsChris, RisteLisa

AIBD
BD treatment

Anxiety is common in people with bipolar disorder and can make their condition worse, increasing the risk of suicide. While effective treatments for anxiety exist, research on treating anxiety in bipolar disorder is lacking. This paper describes a new psychological intervention designed to address anxiety in the context of bipolar disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

97.

Prescription of potentially inappropriate psychotropic drugs in homeless people with schizophrenia and bipolar disorders. Results from the French Housing First (FHF) program.

Author: FondG, TinlandA, BoucekineM, GirardV, LoubièreS, AuquierP, BoyerL,

BD treatment
SZ treatment
Anxiolytic and hypnotic side effects

Guidelines for treating schizophrenia and bipolar disorder now recommend a baseline treatment with antipsychotic medication for schizophrenia and mood stabilizers for bipolar disorder. However, treatment recommendations for depression in these conditions are less clear. Long-term use of anti-anxiety and sleep medications can have side effects and should be stopped as soon as possible.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

98.

Patterns of changes in bipolar depressive symptoms revealed by trajectory analysis among 482 patients with bipolar disorder.

Author: Behrendt-MøllerIda, MadsenTrine, SørensenHolger Jelling, SylviaLouisa, FriedmanEdward S, SheltonRichard C, BowdenCharles L, CalabreseJoseph R, McElroySusan L, KetterTerence A, Reilly-HarringtonNoreen A, GaoKeming, ThaseMichael, V BoboWilliam, TohenMauricio, McInnisMelvin, KamaliMasoud, KocsisJames H, DeckersbachThilo, Köhler-ForsbergOle, NierenbergAndrew A

Bipolar disorder treatment
Depressive symptoms

This study examines how depressive symptoms change over time in people with bipolar disorder during 6 months of treatment. The study aims to identify patterns of depression symptoms and how they differ in these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

99.

'What people diagnosed with bipolar disorder experience as distressing': A meta-synthesis of qualitative research.

Author: WarwickHelen, MansellWarren, PorterCarly, TaiSara

BD treatment

Bipolar disorder has a significant impact on a person's life and has a poor long-term outlook. While treatments focus on managing mood swings, less is known about what people with bipolar disorder find most distressing. This review aims to understand the personal experiences of people with bipolar disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

100.

Aripiprazole augmentation in treating comorbid bipolar disorder and obsessive-compulsive disorder: A systematic review.

Author: AmerioA, OdoneA, GhaemiS N

BD-OCD treatment

Having both bipolar disorder (BD) and obsessive-compulsive disorder (OCD) is common. While antidepressants are typically the first choice for OCD, they can worsen mood swings in BD. The best way to treat BD and OCD together is still being studied.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

101.

Risperidone adjunctive therapy duration in the maintenance treatment of bipolar I disorder: A post hoc analysis.

Author: ValdesMirjana, BertolinSara, QianHong, WongHubert, LamRaymond W, YathamLakshmi N

BD I treatment
Risperidone

Risperidone is a common initial treatment for manic episodes in bipolar disorder. It's unclear whether continuing risperidone along with lithium or valproate after the manic episode has ended helps to prevent future episodes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

102.

Study protocol of a multicenter randomized controlled trial of mindfulness-based cognitive therapy and treatment as usual in bipolar disorder.

Author: HanssenI, HuijbersM J, Lochmann-van BennekomM W H, RegeerE J, StevensA W M M, EversS M A A, WensingM, KupkaR W, SpeckensA E M

BD treatment
MBCT

Many people with bipolar disorder (BD) continue to experience mood problems even when they are not having major episodes, which can impact their lives. While there are treatments, it's not clear how to best manage these ongoing symptoms. This study investigates whether adding Mindfulness-Based Cognitive Therapy (MBCT) to standard treatment for BD will improve symptoms and function in adults with BD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

103.

Lithium for acute mania.

Author: McKnightRebecca F, de La Motte de Broöns de VauvertSaïk J G N, ChesneyEdward, AmitBen H, GeddesJohn, CiprianiAndrea

Bipolar disorder treatment
Lithium

Bipolar disorder is a serious condition that requires effective treatments. Lithium is effective in managing bipolar disorder long-term, reducing mood swings and suicide risk. However, more research is needed to determine if lithium should be the first-line treatment for manic episodes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

104.

Effect of lithium on suicide and mortality in mood disorders: A systematic review.

Author: BörjessonJoakim, GøtzschePeter C

Total mortality reduction

Lithium treatment was found to reduce total mortality in patients with mood disorders but did not have a statistically significant effect on suicide rates. However, the study was limited by small numbers and unreliable data, so the findings should be interpreted cautiously.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

105.

The chronotherapeutic treatment of bipolar disorders: A systematic review and practice recommendations from the ISBD task force on chronotherapy and chronobiology.

Author: GottliebJohn F, BenedettiFrancesco, GeoffroyPierre A, HenriksenTone E G, LamRaymond W, MurrayGreg, PhelpsJames, SitDorothy, SwartzHolly A, CroweMarie, EtainBruno, FrankEllen, GoelNamni, HaarmanBartholomeus C M, InderMaree, KallestadHåvard, Jae KimSeong, MartinyKlaus, MeestersYbe, PorterRichard, Riemersma-van der LekRixt F, RitterPhilipp S, SchultePeter F J, ScottJan, WuJoseph C, YuXin, ChenShenghao

Symptom management

This study examined research on treatments for bipolar disorder (BD) that focus on regulating the body's natural rhythms (chronotherapy). The review looked at the effectiveness and side effects of different chronotherapeutic approaches, including light therapy, dark therapy, sleep deprivation, melatonin medications, interpersonal social rhythm therapy, and cognitive behavioral therapy specifically for bipolar disorder. The study aims to provide evidence-based recommendations for using these treatments for bipolar disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

106.

Use of a serious game to strengthen medication adherence in euthymic patients with bipolar disorder following a psychoeducational programme: A randomized controlled trial.

Author: MaurinKathlyne Dupuis, GirodChloé, ConsoliniJulia Lou, BelzeauxRaoul, EtainBruno, CochetBarbara, LeboyerMarion, GentyCatherine, GamonLucie, PicotMarie Christine, CourtetPhilippe, OliéDr Emilie

BIPOLIFE for adherence

This randomized trial found that the serious game BIPOLIFE® may help patients with bipolar disorder increase their confidence in medications if used regularly.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

107.

Bipolar spectrum disorder: What evidence for pharmacological treatment? A systematic review.

Author: HedeVincent, FavreSophie, AubryJean-Michel, Richard-LepourielHélène

BSD treatment

Bipolar spectrum disorder (BSD) is a broader term that includes conditions that don't fully meet the criteria for bipolar disorder (BD). There are currently no guidelines for treating BSD. This review examines the research on medications for BSD, looking for strong evidence that could lead to treatment recommendations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

108.

The CINP Guidelines on the Definition and Evidence-Based Interventions for Treatment-Resistant Bipolar Disorder.

Author: FountoulakisKonstantinos N, YathamLakshmi N, GrunzeHeinz, VietaEduard, YoungAllan H, BlierPierre, TohenMauricio, KasperSiegfried, MoellerHans Jurgen

Resistant bipolar disorder treatment

Treatment-resistant bipolar disorder is a serious mental health problem, affecting a person's ability to function and causing high healthcare costs. This review examines the definition, clinical characteristics, brain changes, and treatment options for people with bipolar disorder who don't respond to standard treatments. The goal is to develop guidelines for treating this challenging condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

109.

A double blind randomized clinical trial of buprenorphine augmentation for treatment of psychotic symptoms in opioid addicted bipolar patients.

Author: KhaliliNavid, SabahiAbdolreza, VahedianMostafa, AlimardanzadehMehdi

No aggravation of symptoms

Buprenorphine augmentation did not add any efficacy to the usual treatment of psychotic episodes in bipolar disorder type I, although it did not aggravate psychiatric symptoms. Both groups showed significant reductions in psychotic, depressive, and manic symptoms, but there was no significant difference between the buprenorphine and placebo groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

110.

Sequential Multiple Assignment Randomized Treatment (SMART) for Bipolar Disorder at Any Phase of Illness and at least Mild Symptom Severity.

Author: GaoKeming, ArnoldJodi G, PrihodaThomas J, QuinonesMarlon, SinghVivek, SchinagleMartha, ConroyCarla, D'ArcangeloNicole, BaiYuanhan, CalabreseJoseph R, BowdenCharles L

Reduced bipolar symptomatology
Side effects

Lithium and divalproex monotherapy were modestly effective in treating bipolar disorder. Adjunctive therapy with quetiapine or lamotrigine was well-tolerated and more effective in reducing bipolar symptomatology.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

111.

The influence of stage of illness on functional outcomes after psychological treatment in bipolar disorder: A systematic review.

Author: TremainHailey, FletcherKathryn, ScottJan, McEneryCarla, BerkMichael, MurrayGreg

Improved general functioning

Psychosocial interventions for bipolar disorder (BD) may be more effective for general functioning outcomes earlier in the illness course. Further research is needed to understand the impact of illness stage on the effectiveness of these interventions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

112.

Antidepressant light therapy for bipolar patients: A meta-analyses.

Author: DallaspeziaSara, BenedettiFrancesco

Bipolar depression treatment

Treating depression in bipolar disorder is challenging, as antidepressants often don't work well, and can even increase the risk of manic episodes. While light therapy (LT) has shown promise for depression, it's still debated whether it helps people with bipolar disorder, especially those whose depression isn't linked to the seasons.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

114.

The concept and management of acute episodes of treatment-resistant bipolar disorder: a systematic review and exploratory meta-analysis of randomized controlled trials.

Author: FornaroMichele, CarvalhoAndré F, FuscoAndrea, AnastasiaAnnalisa, SolmiMarco, BerkMichael, SimKang, VietaEduard, de BartolomeisAndrea

TRBD treatment
measurement bias
publication bias

This review examines research on treatment-resistant bipolar disorder (TRBD). While several interventions exist, including pramipexole, electroconvulsive therapy (ECT), and clozapine, more research is needed. This includes larger, better-designed trials with consistent definitions of TRBD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

115.

Effects of psychological and pharmacological interventions on anxiety symptoms in patients with bipolar disorder in full or partial remission: A systematic review.

Author: SeebergI, NielsenI B, JørgensenC K, EskestadN D, MiskowiakK W

Anxiety treatment

Anxiety is common in people with bipolar disorder, even when they are not having a mood episode. This can make treatment more difficult, affect their overall well-being, and limit what they can do. This review will examine the research on different treatments for anxiety in people with bipolar disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

116.

Illness stage and predominant polarity in bipolar disorder: Correlation with burden of illness and moderation of treatment outcome.

Author: KamaliMasoud, PeggSamantha, JanosJessica A, BoboWilliam V, BrodyBenjamin, GaoKeming, KetterTerence A, McElroySusan L, McInnisMelvin G, RabideauDustin J, Reilly-HarringtonNoreen A, SheltonRichard C, SylviaLouisa G, TohenMauricio, NierenbergAndrew

Bipolar disorder treatment

Bipolar disorder can be divided into stages, with more advanced stages linked to worse outcomes. People with bipolar disorder also tend to have more depressive or manic episodes. This study found that the stage of the disorder and whether someone has more depressive or manic episodes were related to several factors, such as childhood abuse, anxiety, and past treatments. However, these factors didn't influence how well two medications, lithium and quetiapine, worked. The number of depressive episodes in the past year was linked to poorer treatment outcomes overall. This suggests that early intervention is key for better outcomes in bipolar disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

117.

Associations between cognition and subsequent mood episodes in patients with bipolar disorder and their unaffected relatives: A systematic review.

Author: MiskowiakKamilla Woznica, MariegaardJohanna, JahnFrida Simon, KjærstadHanne Lie

(Hypo)manic relapse
Illness onset risk

Cognitive impairment, poorer verbal memory and executive function, and positive bias were associated with subsequent (hypo)manic relapse in patients with bipolar disorder. Impairments in attention, verbal memory and executive functions, and positive bias were associated with subsequent illness onset in first-degree relatives.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

118.

Do psychological interventions reduce symptoms of depression for patients with bipolar I or II disorder? A meta-analysis.

Author: YilmazSakir, HuguetAnna, KiselySteve, RaoSanjay, WangJianLi, BaurKayti, PriceMolly, O'MahenHeather, WrightKim

Bipolar disorder treatment

Therapy can be helpful for bipolar disorder, but we need to understand how different therapies work for depressive episodes, especially when they are severe. Previous studies have looked at the overall effectiveness of therapy, but haven't examined how well they work for treating depression depending on the severity of the depression.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

119.

[On the treatment of bipolar affective disorder].

Author: PetrovaN N

Bipolar disorder treatment

This study reviewed existing research on bipolar disorder (BD), highlighting the need for effective treatments. The review examined the epidemiology of BD, current treatment approaches, and the use of medications, including quetiapine, for managing both manic and depressive episodes of BD. The review focused on existing research and did not include new trial data.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Russian

120.

Adjunctive antidepressants for the acute treatment of bipolar depression: A systematic review and meta-analysis.

Author: HuYuliang, ZhangHuijuan, WangHongyan, WangChris, KungSimon, LiChunbo

No increased mood switch
Well tolerated

Adjunctive antidepressants did not clinically improve the response rate or depressive symptoms in patients with acute bipolar depression. They were well-tolerated and did not increase the risk of short-term mood switch.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

121.

Bipolar disorder treatment according to illness trajectory: a systematic review of clinical trials.

Author: MarchionattiLauro Estivalete, Antonelli-SalgadoThyago, ErthalIsadora Nunes, LopesSávio Luiz Santos, LucasLuiza Silveira, RebouçasDiego Barreto, PassosIves Cavalcante

Bipolar disorder treatment

Current bipolar disorder treatment focuses on preventing episodes and managing them during acute phases, but less attention is given to how the illness progresses over time. This review examined studies that investigated the impact of illness progression on treatment effectiveness. While studies found that treatment effectiveness decreases as the illness progresses, supporting the idea of early intervention, there wasn't enough information to recommend specific treatments based on different stages of the illness. The review also identified areas where future research could be improved, suggesting the use of a standardized system to categorize the stage of the illness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

122.

A systematic review of the literature on telepsychiatry for bipolar disorder.

Author: FarrellAbigail, GeorgeNevita, AmadoSelen, WozniakJanet

BP disorder treatment

Bipolar disorder is a serious condition that often goes undiagnosed, affecting people of all ages. This review examined research on the use of telepsychiatry (mental health care through video or phone calls) for diagnosing and treating bipolar disorder. The study aims to understand the current evidence for using telehealth for this condition.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

123.

Comparing the effectiveness of imagery focussed cognitive therapy to group psychoeducation for patients with bipolar disorder: A randomised trial.

Author: van den BergK C, HendricksonA T, HalesS A, VonckenM, KeijsersG P J

Bipolar disorder treatment

Bipolar disorder is a serious mental illness that requires ongoing treatment. While medication is commonly used, relapse is common. Therapy can be helpful, but new approaches are needed. This study will compare the effectiveness of group education (PE) with a type of therapy that uses imagery (ImCT) for people with bipolar disorder.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

124.

Distinct brain activity alterations of treatment for bipolar disorders with psychotherapy and drug therapy: activation likelihood estimation meta-analysis.

Author: LuoJingyi, YiPengcheng, LiangMeng, ZhangShuyu, TaoQian, LiNi, ZhangHan, WenJialin, XueXinrong, FanChuan, LiXiaoming

A meta-analysis of 21 studies using activation likelihood estimation found that psychotherapy and drug therapy for bipolar disorders (BDs) might have distinct effects on brain activity. Psychotherapy showed increased activation in frontal areas, suggesting a top-down effect, while drug therapy showed increased activation in limbic areas, suggesting a bottom-up effect.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

125.

[Effects of lithium, valproic acid, carbamazepine and antipsychotic agents on cognition in bipolar disorders-A systematic review].

Author: LeopoldSophie, QuanteArnim

Bipolar disorder treatment

We don't know enough about the long-term effects of bipolar disorder treatments, especially on thinking skills and the risk of dementia. Some studies suggest that certain treatments might be better for the brain than others. This review will summarize the current research on this topic.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

126.

Effect of lithium administration on brain activity under an emotion regulation paradigm in healthy participants: a functional magnetic resonance imaging study.

Author: Artiach HortelanoPilar, MartensMarieke A G, PringleAbigail, HarmerCatherine J

Improved emotion regulation
None reported

Lithium (800mg) may have a potential effect on emotion regulation (ER) through its effects on brain activity and connectivity. In a double-blind study of 33 healthy volunteers, participants receiving lithium showed decreased activity in prefrontal and posterior parietal cortices and increased activity in the right superior temporal gyrus during reappraisal.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

127.

Lithium in bipolar depression: A review of the evidence.

Author: RiedingerMirjam A, van der WeeNic J A, GiltayErik J, de LeeuwMax

Bipolar depression treatment

Lithium is a common treatment for manic episodes and to prevent episodes in people with bipolar disorder. While it's also considered a potential treatment for depressive episodes in bipolar disorder, we need more research on its effectiveness in treating depression compared to what we know about its use for other phases of bipolar disorder.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

128.

Efficacy of cognitive behavioural therapy for bipolar disorder: A systematic review.

Author: Valdivieso-JiménezGlauco

BD treatment

Bipolar disorder is a serious and long-term mental illness that causes extreme mood swings. While medications and therapy are available, we need more research to understand how well cognitive behavioral therapy (CBT) works for people with bipolar disorder.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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