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Treatments for spasticity and pain in multiple sclerosis: a systematic review.

Author: BeardS, HunnA, WightJ

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

There is limited evidence supporting the effectiveness of several oral medications for spasticity in multiple sclerosis, including baclofen, dantrolene, diazepam, and tizanidine. Botulinum toxin and intrathecal baclofen are effective in reducing spasticity and associated with functional benefit, but are invasive and expensive. There is insufficient evidence to evaluate the effectiveness of any drug treatment for pain in multiple sclerosis.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To identify the drug treatments currently available for the management of spasticity and pain in multiple sclerosis (MS), and to evaluate their clinical and cost-effectiveness. DATA SOURCES: Electronic bibliographic databases, National Research Register, MRC Clinical Trials Register and...See full text at original site
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引用元：
https://doi.org/10.3310/hta7400

データ提供：米国国立医学図書館（NLM）

Managing Spasticity and Pain in Multiple Sclerosis: A Comprehensive Review

This comprehensive study explores the challenging landscape of [multiple sclerosis (MS)], focusing on the management of two common symptoms: spasticity and pain. The researchers conducted a systematic review to assess the effectiveness of various drug treatments for these debilitating conditions.

Navigating Treatment Options for Spasticity and Pain in MS

The review found limited evidence supporting the effectiveness of oral medications for spasticity, including baclofen, dantrolene, diazepam, and tizanidine. However, it highlighted strong evidence for the efficacy of botulinum toxin (BT) and intrathecal baclofen in reducing spasticity. Furthermore, the review revealed a lack of consistent evidence supporting the use of specific interventions for pain in MS.

Finding Relief in the Desert of MS: Spasticity and Pain Management

Imagine MS as a vast desert, where spasticity and pain are like mirages, tempting but elusive. This research guides us toward potential oasis of relief, offering insights into the effectiveness of different treatment options for these challenging conditions.

Dr.Camel's Conclusion

This study serves as a beacon in the desert of MS, providing guidance for managing spasticity and pain. While the landscape of treatment options is still evolving, this research offers valuable insights for clinicians and patients seeking relief from these debilitating symptoms.

Date :
  1. Date Completed 2004-03-04
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

14636486

DOI: Digital Object Identifier

10.3310/hta7400

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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