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Lamotrigine in treatment-resistant schizophrenia: a randomized placebo-controlled crossover trial.

Author: EronenMarkku, HallikainenTero, KotilainenIrma, PutkonenAnu, Repo-TiihonenEila, RyynänenOlli-Pekka, TiihonenJari, ToivonenPäivi, WahlbeckKristian

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the effectiveness of lamotrigine as an add-on treatment to clozapine in patients with clozapine-resistant schizophrenia, exploring the potential benefit of targeting glutamate receptors.
Paper Details　
Original Abstract of the Article :
There is no evidence from randomized, controlled trials that demonstrate effectiveness for any pharmacological treatment in clozapine-resistant schizophrenia. Since the introduction of chlorpromazine, all antipsychotics with proven efficacy on positive symptoms have been dopamine antagonists, but re...See full text at original site
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引用元：
https://doi.org/10.1016/s0006-3223(03)00524-9

データ提供：米国国立医学図書館（NLM）

Lamotrigine for Treatment-Resistant Schizophrenia

Imagine the desert of the mind, a vast and often challenging landscape to navigate. This research focuses on schizophrenia, a complex mental illness that can significantly impact a person's thoughts, feelings, and behaviors. The study investigates the effectiveness of lamotrigine, an anticonvulsant medication, for treating treatment-resistant schizophrenia, a form of schizophrenia that does not respond to traditional treatments.

Lamotrigine's Potential for Schizophrenia Treatment

The researchers conducted a randomized placebo-controlled crossover trial to evaluate lamotrigine's effectiveness in treating positive schizophrenic symptoms in patients who had not responded to clozapine, a medication considered the gold standard for treatment-resistant schizophrenia. This is like seeking a new oasis in the desert, exploring alternative pathways to alleviate the symptoms of this challenging condition.

Implications for Schizophrenia Treatment

This research suggests that lamotrigine could offer a potential treatment option for patients with treatment-resistant schizophrenia. If proven effective, lamotrigine could offer a lifeline for those navigating the desert of schizophrenia, providing hope for improved symptom management and quality of life.

Dr. Camel's Conclusion

This study delves into the complex world of schizophrenia treatment, seeking new solutions for those with treatment-resistant conditions. Lamotrigine's potential as a therapeutic agent offers a glimmer of hope in the desert of mental illness, potentially leading to better treatments and improved outcomes for patients.
Date :
  1. Date Completed 2004-02-04
  2. Date Revised 2019-08-15
Further Info :

Pubmed ID

14643092

DOI: Digital Object Identifier

10.1016/s0006-3223(03)00524-9

Related Literature

Article Analysis
・Effective treatment of schizophrenia
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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