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Involvement of the brain serotonergic system in the locomotor stimulant effects of chlorpheniramine in Wistar rats: implication of postsynaptic 5-HT1A receptors.

Author: KaramanakosPetros N, MarselosMarios, PappasPeriklis

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the influence of chlorpheniramine (CPA), an antihistamine, on the locomotor activity of rats and its effects on brain biogenic monoamines. CPA induced hyperlocomotion and a hypothermic response in rats. This hyperlocomotion was associated with an increase in 5-HT levels in the striatum and hypothalamus, suggesting that the central serotonergic system, particularly postsynaptic 5-HT1A receptors, plays a key role in the locomotor stimulant effects of CPA.
Paper Details　
Original Abstract of the Article :
Antihistamines, such as chlorpheniramine (CPA), are lipophilic agents which readily cross the blood-brain barrier, producing sedation in 10-25% of users. However, with excessive doses instead of sedation a stimulating action has been reported. The aim of the present study was to investigate the infl...See full text at original site
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引用元：
https://doi.org/10.1016/s0166-4328(03)00193-1

データ提供：米国国立医学図書館（NLM）

Chlorpheniramine and the Brain Serotonergic System

This research investigates the role of the brain serotonergic system in the locomotor stimulant effects of chlorpheniramine (CPA), an antihistamine. The study explored the effects of CPA on locomotor activity in rats, measuring brain monoamine levels in different regions. The results indicate that CPA induces hyperlocomotion in rats, which is associated with increased serotonin (5-HT) levels in the striatum and hypothalamus. The authors suggest that postsynaptic 5-HT1A receptors play a key role in mediating the locomotor stimulant effects of CPA.

Chlorpheniramine: A Stimulant Effect Mediated by Serotonin

This study explores the intriguing link between chlorpheniramine (CPA), an antihistamine, and the brain serotonergic system. The authors demonstrate that CPA induces hyperlocomotion in rats, a finding that is associated with increased serotonin levels in the striatum and hypothalamus. This research provides valuable insights into the neurochemical mechanisms underlying the stimulating effects of CPA.

The Shifting Sands of Neurotransmission

The brain, like a vast and intricate desert landscape, relies on complex systems of neurotransmission to regulate our thoughts, emotions, and behaviors. This research, like an explorer delving into the heart of the desert, investigates the role of the serotonergic system in mediating the effects of chlorpheniramine (CPA). The authors reveal a fascinating connection between CPA and serotonin, highlighting the complexity of neurochemical interactions and the potential for unexpected effects from medications.

Dr. Camel's Conclusion

This study unveils the intricate relationship between chlorpheniramine (CPA) and the brain serotonergic system, offering a glimpse into the complex world of neurotransmission. The findings provide valuable insights into the potential for unexpected effects from medications and highlight the importance of understanding the interplay between different neurochemical systems in the brain.

Date :
  1. Date Completed 2004-03-01
  2. Date Revised 2019-08-27
Further Info :

Pubmed ID

14684260

DOI: Digital Object Identifier

10.1016/s0166-4328(03)00193-1

Related Literature

Article Analysis
・Effects of chlorpheniramine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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