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Open-label trial of an injection depot formulation of buprenorphine in opioid detoxification.

Author: BigelowGeorge E, JohnsonRolley E, KerriganJames H, LiebsonIra A, NuwayserElie S, SigmonStacey C, SobelBai-Fang X, WalshSharon L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This first-in-human study evaluated the safety and pharmacokinetics of a single-dose buprenorphine depot in opioid-dependent individuals. The depot provided effective relief from opioid withdrawal and substantial opioid blockade for 6 weeks, demonstrating its potential for enhancing opioid agonist treatment while minimizing abuse risk.
Paper Details　
Original Abstract of the Article :
Buprenorphine, a partial mu-opioid agonist, has been shown effective for treatment of opioid dependence but also has some abuse potential. A novel formulation of buprenorphine, using a polymer microcapsule depot sustained-release technology, has been developed which may offer effective treatment of ...See full text at original site
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引用元：
https://doi.org/10.1016/j.drugalcdep.2003.08.006

データ提供：米国国立医学図書館（NLM）

Buprenorphine Depot: A New Weapon Against Opioid Addiction

The battle against [opioid dependence] is a long and arduous one, requiring innovative and effective treatment strategies. This study delves into the potential of a novel [buprenorphine depot formulation] for [opioid detoxification], offering a promising approach to managing this complex condition.

The researchers evaluated the [safety] and [pharmacokinetics] of this [buprenorphine depot] in [opioid-dependent volunteers], finding that it was well-tolerated and effectively suppressed [symptoms of opioid withdrawal]. This suggests that the [depot formulation] could provide sustained relief from [withdrawal symptoms] and potentially improve patient compliance with treatment.

Furthermore, the [buprenorphine depot] demonstrated significant [opioid blockade] for an extended period of time, potentially reducing the risk of [relapse] and [abuse potential]. This exciting finding opens new avenues for exploring the use of [depot formulations] as a more effective and safer approach to [opioid dependence] treatment.

Buprenorphine Depot: A Sustained Shield Against Opioid Withdrawal

The study suggests that the [buprenorphine depot] could be a valuable addition to the arsenal of tools used to combat [opioid dependence]. By providing sustained relief from [withdrawal symptoms] and reducing the risk of [relapse], the [depot formulation] could empower patients to navigate the challenging path of [opioid detoxification].

Buprenorphine Depot: A Beacon of Hope in the Opioid Desert

This research offers a glimmer of hope in the vast and unforgiving desert of [opioid dependence]. The development of a [buprenorphine depot formulation] could provide a more sustainable and effective treatment option, empowering patients to break free from the cycle of addiction. This research underscores the ongoing quest for innovative solutions to address this pervasive and challenging public health issue.

Date :
  1. Date Completed 2004-08-26
  2. Date Revised 2019-09-06
Further Info :

Pubmed ID

14687955

DOI: Digital Object Identifier

10.1016/j.drugalcdep.2003.08.006

SNS
PICO Info
in preparation
Languages

English

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