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[Differential effects on serum IGF-1 of tibolone (5 mg/day) vs combined continuous estrogen/progestagen in post menopausal women].

Author: AedoSócrates, DuartePatricia, GallardoEnrique, PorcileArnaldo

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tibolone and conjugated estrogens/medroxyprogesterone acetate both reduced urinary calcium in postmenopausal women. Tibolone also increased serum IGF-1 levels.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Tibolone has estrogenic, androgenic and progestational effects and is used in post menopausal women. It apparently has weaker effects on endometrial proliferation and mammary stimulation than conventional hormone replacement therapy. AIM: To compare the metabolic effects of tibolone (5 ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/14692305

データ提供：米国国立医学図書館（NLM）

Tibolone vs. Combined Estrogen/Progestagen: A Tale of Two Hormones

This research compares the metabolic effects of tibolone, a synthetic steroid with estrogenic, androgenic, and progestational properties, and combined continuous estrogen/progestagen therapy in postmenopausal women. The authors investigated the effects of these treatments on serum IGF-1 levels, a hormone involved in growth and development.

Exploring the Metabolic Effects of Different Hormones

The study found that tibolone significantly increased serum IGF-1 levels, while combined continuous estrogen/progestagen therapy did not. This research is like exploring two different oases in the desert of postmenopausal hormone therapy, revealing the distinct metabolic effects of different hormone regimens.

Tibolone: A Unique Impact on IGF-1

The study highlights the unique impact of tibolone on serum IGF-1 levels, suggesting a potential benefit for bone health and overall well-being in postmenopausal women. This finding, like a precious pearl discovered in a desert oasis, offers valuable insights into the potential of tibolone as a hormone replacement therapy.

Dr. Camel's Conclusion

This study reveals the distinct metabolic effects of tibolone and combined continuous estrogen/progestagen therapy in postmenopausal women, highlighting the unique impact of tibolone on serum IGF-1 levels. The findings suggest that tibolone may have beneficial effects on bone health and overall well-being in postmenopausal women, providing a valuable alternative to traditional hormone replacement therapy. This research, like a camel caravan navigating the diverse landscape of postmenopausal hormone therapy, offers valuable insights into the complex interplay of hormones and their impact on women's health.

Date :
  1. Date Completed 2004-03-11
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

14692305

DOI: Digital Object Identifier

14692305

SNS
PICO Info
in preparation
Languages

Spanish

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