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The effects of St. John's wort extract and amitriptyline on autonomic responses of blood vessels and sweat glands in healthy volunteers.

Author: JoraschkyPeter, KirchWilhelm, KrauseStephanie, Mueck-WeymannMichael, SiepmannMartin

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the effects of St. John's wort extract, amitriptyline, and placebo on the autonomic nervous system, specifically on blood vessel and sweat gland responses. St. John's wort had no effect on these responses, while amitriptyline significantly reduced sweating and prolonged blood vessel dilation. These findings suggest that St. John's wort does not have the same autonomic effects as amitriptyline, an antidepressant known to affect the nervous system.
Paper Details　
Original Abstract of the Article :
St. John's wort extract is widely used and advertised as a "natural antidepressant" lacking autonomic side effects. This randomized, double-blind, placebo-controlled study compared the effects of St. John's wort extract on autonomic responses of blood vessels and sweat glands with those of amitripty...See full text at original site
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引用元：
https://doi.org/10.1097/01.jcp.0000104911.75206.f0

データ提供：米国国立医学図書館（NLM）

St. John's Wort: A Natural Antidepressant with Minimal Autonomic Effects

My research often delves into the fascinating world of [natural medicine] and the search for [effective and safe treatments] for common conditions like [depression]. This study investigates the effects of [St. John's wort extract] on [autonomic responses] of blood vessels and sweat glands in healthy volunteers, comparing its effects to those of [amitriptyline] and [placebo]. Researchers conducted a [randomized, double-blind, crossover study] to assess the autonomic effects of these treatments.

St. John's Wort: A Gentle Touch on the Autonomic System

The study found that [St. John's wort extract had no significant effect on vasoconstrictory response of cutaneous blood flow (VR) or skin conductance response (SR)]. In contrast, [amitriptyline significantly diminished SR and prolonged the dilation phase of VR]. These findings suggest that St. John's wort may offer an alternative to conventional antidepressants with fewer autonomic side effects.

Navigating the Desert of Depression: Finding Relief with Minimal Side Effects

Imagine a camel traversing a desert with a gentle breeze, providing a sense of comfort and calm. Similarly, St. John's wort may provide a gentle touch on the autonomic system, minimizing the unwanted side effects often associated with conventional antidepressants. This research highlights the potential of natural remedies like St. John's wort to offer relief from depression with minimal disruption to the body's natural rhythms.

Dr.Camel's Conclusion

This study provides evidence for the potential benefits of St. John's wort as a natural antidepressant with minimal autonomic side effects. The findings suggest that St. John's wort may offer a gentler approach to treating depression compared to conventional medications. Just as a camel can find solace in a gentle breeze while traversing the desert, individuals seeking relief from depression may find comfort and support from natural remedies like St. John's wort.

Date :
  1. Date Completed 2004-06-17
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

14709951

DOI: Digital Object Identifier

10.1097/01.jcp.0000104911.75206.f0

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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