Side Effects of st. john's wort: A Synthesis of Findings from 4 Studies

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Original Abstract of the Article

Main research findings

St. John's wort extract is often used and promoted as a "natural antidepressant" without autonomic side effects. However, studies have shown that it can affect the autonomic nervous system. 1 Some research suggests that St. John's wort extract can be an effective and safe alternative to SSRIs for treating depression. 2

Reasons for side effects

St. John's wort extract can interact with other medications, potentially leading to serious side effects. 3 The extract can also cause photosensitivity, making the skin more sensitive to sunlight.

Common side effects

Photosensitivity

St. John's wort extract can cause photosensitivity. This side effect can be worsened by exposure to sunlight.

Drug interactions

St. John's wort extract can interact with other medications. 3 In particular, it may interact with SSRIs, potentially leading to serotonin syndrome. 3 Additionally, St. John's wort can lower blood levels of cyclosporine, warfarin, and theophylline. 3

Side effects management

Photosensitivity

To prevent photosensitivity, it's important to limit sun exposure and use sunscreen.

Drug interactions

When taking St. John's wort extract, it's crucial to consult with a doctor or pharmacist to discuss potential interactions with other medications. 3

Comparison between studies

Commonalities in studies

Multiple studies have shown that St. John's wort extract can be effective for treating depression. Additionally, St. John's wort extract is generally considered safe.

Differences in studies

The effectiveness of St. John's wort extract can vary depending on the study. 2 The incidence of side effects can also differ between studies.

Points to note regarding application to real life

While St. John's wort extract may be helpful for treating depression, it also carries the risk of side effects. When considering using St. John's wort extract, it's essential to consult with a doctor or pharmacist to discuss the most suitable approach for your specific situation. 3

Current limitations of research

More research is needed to investigate the effectiveness and safety of St. John's wort extract in more detail. 2

Future research directions

Research is required to examine the long-term effectiveness and safety of St. John's wort extract. 2 Additionally, studies are needed to explore how St. John's wort extract affects different types of depression.

Conclusion

While St. John's wort extract can be beneficial for treating depression, it also carries potential risks of side effects. When considering St. John's wort extract, consult with a doctor or pharmacist to discuss appropriate usage for your individual circumstances. 3

Literature analysis of 4 papers
Positive Content
3
Neutral Content
0
Negative Content
1
Article Type
1
1
0
1
4
1.

The effects of St. John's wort extract and amitriptyline on autonomic responses of blood vessels and sweat glands in healthy volunteers.

Author: SiepmannMartin, KirchWilhelm, KrauseStephanie, JoraschkyPeter, Mueck-WeymannMichael

Depression treatment

This study compared the effects of St. John's wort extract, amitriptyline, and placebo on the autonomic nervous system, specifically on blood vessel and sweat gland responses. St. John's wort had no effect on these responses, while amitriptyline significantly reduced sweating and prolonged blood vessel dilation. These findings suggest that St. John's wort does not have the same autonomic effects as amitriptyline, an antidepressant known to affect the nervous system.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

[The risks of combining medicine and herbal remedies].

Author: GoldsteinL H, EliasM, BerkovitchM, GolikA

Drug interactions
Side effects

Herbal remedies, while considered "natural," can have serious side effects and interact with conventional medications. The study reviewed commonly used herbs in Israel, highlighting potential adverse reactions and drug interactions, emphasizing the need for physicians to be aware of their patients' herbal use.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Hebrew

4.

Hypericin for visualization of high grade gliomas: first clinical experience.

Author: RitzR, DanielsR, NoellS, FeiglG C, SchmidtV, BornemannA, RaminaK, MayerD, DietzK, StraussW S L, TatagibaM

Malignant glioma visualization

Hypericin, a component of St. Johns Wort, effectively visualizes malignant gliomas. In 5 patients with recurrent malignant glioma, Hypericin was given intravenously 6 hours before surgery. Tumor tissue was clearly distinguishable from normal brain tissue under fluorescence mode. Hypericin was well tolerated with no observed side effects.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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