Tic reduction with risperidone versus pimozide in a randomized, double-blind, crossover trial.

Author: BattersonJ Robert, GilbertDonald L, SalleeFloyd R, SethuramanGopalan

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To compare the tic suppression, electrocardiogram (ECG) changes, weight gain, and side effect profiles of pimozide versus risperidone in children and adolescents with tic disorders. METHOD: This was a randomized, double-blind, crossover (evaluable patient analysis) study. Nineteen childr...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://pubmed.ncbi.nlm.nih.gov/14726728

データ提供:米国国立医学図書館(NLM)

Tic Reduction: Comparing Risperidone and Pimozide in Children with Tic Disorders

Tic disorders, such as Tourette's syndrome, can significantly impact the lives of children and adolescents. This study compares the effectiveness of risperidone and pimozide in reducing tic severity, while also evaluating their effects on electrocardiogram (ECG) changes, weight gain, and side effects. The authors conducted a randomized, double-blind, crossover study involving children and adolescents with tic disorders. The study findings reveal that risperidone was more effective in reducing tic severity than pimozide, but was associated with greater weight gain. Neither medication produced significant ECG changes.

Risperidone: A Potential Advantage for Tic Reduction

The study results suggest that risperidone might offer a potential advantage over pimozide in reducing tic severity. However, the greater weight gain associated with risperidone raises concerns and highlights the need for careful monitoring of patients receiving this medication. The study's findings provide valuable insights for healthcare providers in choosing the most appropriate treatment for tic disorders, considering both efficacy and potential side effects.

Navigating the Desert of Tic Disorders: Finding the Right Path to Relief

The study underscores the complexity of treating tic disorders, particularly in children and adolescents. Choosing the most effective and safe medication requires careful consideration of individual patient needs and potential risks. It's like navigating a vast desert, weighing the benefits of different oases against the potential dangers of each route. This research provides valuable information to guide healthcare providers in selecting the best treatment path for their young patients.

Dr. Camel's Conclusion

The study provides valuable insights into the comparative efficacy of risperidone and pimozide in reducing tic severity. While risperidone demonstrates potential superiority in tic suppression, its association with greater weight gain necessitates careful monitoring of patients. The study emphasizes the importance of individualizing treatment decisions for tic disorders, considering both efficacy and potential side effects. This research contributes to our understanding of tic disorders and guides us in finding the most effective and safe treatment strategies for young patients.

Date :
  1. Date Completed 2004-03-08
  2. Date Revised 2021-04-02
Further Info :

Pubmed ID

14726728

DOI: Digital Object Identifier

S0890-8567(09)61278-8

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.