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Long-term survival with advanced ovarian cancer: an analysis of 5-year survivors in the Australian trial comparing combination versus sequential chlorambucil and cisplatin therapy.

Author: SolomonH J, SwansonC E, TattersallM H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 318 patients with invasive ovarian cancer found a 5-year survival rate of 11.4%, while a group of 20 patients with low-potential malignancy had a 5-year survival rate of 85%. There was no significant difference in survival between two chemotherapy regimens: chlorambucil and cisplatin combined versus chlorambucil followed by cisplatin. Patients with less residual tumor after surgery had better 5-year survival rates (15% vs. 8.5%). The study concluded that complete surgical response was a stronger predictor of survival than clinical response. The study also emphasizes the importance of central pathology review for accurate diagnosis and treatment of ovarian cancer.
Paper Details　
Original Abstract of the Article :
Of 369 patients with apparent advanced ovarian cancer entered on a randomized trial between September 1979 and June 1983, 56 survived more than 5 years. Central pathology review confirmed the diagnosis in 318 cases (15 cases not ovarian primary, 36 slides did not reach central review). Two hundred n...See full text at original site
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引用元：
https://doi.org/10.1016/0090-8258(92)90129-7

データ提供：米国国立医学図書館（NLM）

A Long-Term Perspective on Ovarian Cancer Treatment: Analyzing 5-Year Survivors

Ovarian cancer is a serious health concern, often diagnosed at later stages when treatment options become more limited. This study delves into the long-term survival outcomes of patients with advanced ovarian cancer, focusing on a group of women who survived for at least 5 years after diagnosis. The study examines the clinical, pathological, and treatment characteristics of these long-term survivors, aiming to identify factors associated with improved survival in this challenging disease.

Unveiling the Factors Associated with Long-Term Survival: A Comprehensive Analysis of Ovarian Cancer Survivors

The study found that a significant proportion of women with low-potential malignancy survived for at least 5 years, highlighting the importance of accurate diagnosis and individualized treatment approaches. The study also noted a strong correlation between complete surgical response and long-term survival, emphasizing the importance of achieving optimal surgical outcomes in managing advanced ovarian cancer. The study concluded that while clinical response was a poor indicator of survival, complete surgical response was a strong predictor of long-term survival.

Hope for the Future: Improving Outcomes in Ovarian Cancer Treatment

This study offers hope for the future of ovarian cancer treatment, emphasizing the importance of accurate diagnosis, optimal surgical intervention, and individualized treatment approaches to improve long-term survival outcomes. Further research is crucial to identify additional factors associated with long-term survival and develop new and innovative therapies to enhance patient outcomes in this challenging disease.

Dr.Camel's Conclusion

This study provides valuable insights into the long-term survival outcomes of patients with advanced ovarian cancer, highlighting the importance of accurate diagnosis, optimal surgical intervention, and individualized treatment approaches. The findings suggest that complete surgical response is a strong predictor of long-term survival, underscoring the critical role of surgery in managing advanced ovarian cancer. This research offers a promising glimpse into the future of ovarian cancer treatment, motivating further research into new and innovative therapies to improve outcomes for patients with this challenging disease.

Date :
  1. Date Completed 1993-02-03
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

1473740

DOI: Digital Object Identifier

10.1016/0090-8258(92)90129-7

SNS
PICO Info
in preparation
Languages

English

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