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Effects of epsilon-aminocaproic acid and aprotinin on leukocyte-platelet adhesion in patients undergoing cardiac surgery.

Author: BrouseChad F, EberhartRobert C, GreilichPhilip E, JessenMichael E, RinderChristine S, RinderHenry M, SandovalBernardo A, SmithBrian R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study determined the relative effectiveness of the antifibrinolytics, aprotinin and EACA, at reducing leukocyte and platelet activation and leukocyte-platelet conjugate formation in patients undergoing cardiopulmonary bypass.
Paper Details　
Original Abstract of the Article :
The administration of aprotinin during cardiopulmonary bypass (CPB) is hypothesized to decrease activation of leukocytes and platelets and possibly reduce their adhesion. Although epsilon-aminocaproic acid (EACA) shares the ability of aprotinin to inhibit excessive plasmin activity after CPB, its ef...See full text at original site
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引用元：
https://doi.org/10.1097/00000542-200402000-00008

データ提供：米国国立医学図書館（NLM）

Epsilon-aminocaproic Acid vs. Aprotinin: A Battle in the Desert of Cardiac Surgery

This research is like a desert scout comparing different routes for navigating a treacherous landscape, in this case, cardiac surgery. The authors investigated the effects of epsilon-aminocaproic acid (EACA) and aprotinin, two antifibrinolytics, on leukocyte and platelet activation during cardiopulmonary bypass (CPB). The study found that both agents reduced leukocyte and platelet activation, but aprotinin was more effective in reducing leukocyte-platelet conjugate formation.

Aprotinin: A More Effective Route in the Desert of Cardiac Surgery

This study suggests that aprotinin may be a more effective antifibrinolytic for reducing leukocyte-platelet interactions during cardiac surgery. The researchers found that aprotinin was superior to EACA in reducing leukocyte-platelet conjugate formation, potentially leading to better outcomes for patients undergoing CPB.

Exploring the Landscape of Antifibrinolytic Therapy

This study highlights the importance of exploring different antifibrinolytic options during cardiac surgery. The researchers demonstrated that aprotinin may offer a more effective approach to reducing leukocyte-platelet activation and minimizing the risk of inflammatory complications associated with CPB. This finding underscores the need for continued research and innovation in this area of cardiovascular medicine.

Dr.Camel's Conclusion

This research is like a desert explorer meticulously comparing different paths through a challenging terrain. The authors found that aprotinin may be a more effective route for navigating the complexities of cardiac surgery, leading to better outcomes for patients undergoing CPB.

Date :
  1. Date Completed 2004-02-24
  2. Date Revised 2019-06-28
Further Info :

Pubmed ID

14739793

DOI: Digital Object Identifier

10.1097/00000542-200402000-00008

Related Literature

Article Analysis
・Effects of aminocaproic acid
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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