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Effects of topically applied 2% epinephrine and 0.1% dipivalyl epinephrine on the adrenergic nerves as revealed by histofluorescence.

Author: DonahueM E, FlachA J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Epinephrine and dipivalyl epinephrine can result in chemical sympathectomy in rats.
Paper Details　
Original Abstract of the Article :
Commercially available epinephrine (EPI) 2% and dipivalyl epinephrine (DPE) 0.1% ophthalmic solutions were instilled twice daily in the eyes of rats over a 12-week period and compared to placebo-vehicle-treated controls. Fluorescence photomicrographs of stretch preparations from the dilator muscle o...See full text at original site
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引用元：
https://doi.org/10.1159/000310320

データ提供：米国国立医学図書館（NLM）

Epinephrine and Dipivalyl Epinephrine: Impact on Adrenergic Nerves in the Eye

This study investigates the effects of topically applied epinephrine (EPI) and dipivalyl epinephrine (DPE) on adrenergic nerves in the rat eye. The researchers instilled commercially available EPI 2% and DPE 0.1% ophthalmic solutions twice daily in the eyes of rats for 12 weeks and compared the results to control groups receiving a placebo vehicle. The study found that both EPI and DPE treatment resulted in weaker fluorescence in the dilator muscle of the rat irises, indicating a reduction in adrenergic nerve activity. This finding supports previous research suggesting that topical application of EPI and DPE can lead to a chemical sympathectomy, effectively reducing the activity of sympathetic nerves in the eye.

The Desert of Sympathetic Nerves: A Glimpse into Chemical Sympathectomy

The study's findings provide valuable insights into the impact of EPI and DPE on the sympathetic nervous system, demonstrating their ability to induce a chemical sympathectomy. This research contributes to our understanding of the mechanisms by which these medications affect the eye, potentially informing the development of new therapeutic strategies for eye-related conditions.

Navigating the Desert of Eye Health

The desert of eye health can be vast and complex, with a myriad of conditions requiring careful management. This research offers a valuable glimpse into the effects of EPI and DPE on the sympathetic nervous system, providing insights into the mechanisms underlying their use in treating eye conditions.

Dr. Camel's Conclusion

This study sheds light on the impact of EPI and DPE on the sympathetic nervous system, particularly in the context of the eye. The research provides valuable information for understanding the mechanisms underlying these medications' effects and their potential applications in treating eye-related conditions.

Date :
  1. Date Completed 1993-02-04
  2. Date Revised 2018-02-17
Further Info :

Pubmed ID

1475087

DOI: Digital Object Identifier

10.1159/000310320

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・Effects of dipivefrin ophthalmic
SNS
PICO Info
in preparation
Languages

English

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