Effects of dipivefrin ophthalmic: A Synthesis of Findings from 16 Studies

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Original Abstract of the Article

Major Research Findings

Dipivefrin eye drops are effective in lowering intraocular pressure in patients with open-angle glaucoma and ocular hypertension. 16 , 13 , 14 It can be used in combination with timolol eye drops to enhance the effect. 16 Dipivefrin has been shown to have an additive effect in lowering intraocular pressure when used in combination with timolol. 16 The effect of dipivefrin on intraocular pressure is comparable to that of adrenaline, but it is not generally considered as a first-line treatment for open-angle glaucoma and ocular hypertension. 13 Dipivefrin may also improve blood circulation in the optic nerve head. 10

Benefits and Risks

Benefits Summary

Dipivefrin eye drops have been proven to effectively lower intraocular pressure in patients with open-angle glaucoma and ocular hypertension. 16 , 13 , 14 Moreover, dipivefrin can be used in combination with timolol to enhance the effect. 16

Risks Summary

Dipivefrin may cause side effects, such as scarring of the eyelid conjunctiva, cystoid macular edema, and contact dermatitis. 8 , 15 , It can also interact with other eye drops. 7

Comparison Between Studies

Commonalities

Multiple studies have confirmed the effectiveness of dipivefrin in reducing intraocular pressure. 16 , 13 , 14 Furthermore, many studies indicate that dipivefrin can be used in combination with other eye drops. 16 , 14

Differences

The occurrence of side effects associated with dipivefrin varies across different studies. 13 15 The duration of dipivefrin's effectiveness in reducing intraocular pressure also differs between studies. 16

Consistency and Contradictions in Results

While dipivefrin has consistently demonstrated its effectiveness in lowering intraocular pressure. 16 , 13 , 14 However, the risk of side effects varies between studies. 13 15

Noteworthy Points for Application in Daily Life

Dipivefrin can be a valuable tool for treating open-angle glaucoma and ocular hypertension. 16 , 13 , 14 However, it is crucial to use it under the guidance of a healthcare professional and to be aware of potential side effects. 8 , 15

Limitations of Current Research

The current body of research on dipivefrin is limited. 16 , 13 , 14 Further research is needed to fully understand its long-term safety and efficacy. 8 , 15

Directions for Future Research

Long-term studies are necessary to assess the safety and effectiveness of dipivefrin. 16 , 13 , 14 Research should also aim to identify risk factors for side effects. 8 , 15

Conclusion

Dipivefrin is a useful medication for treating open-angle glaucoma and ocular hypertension. 16 , 13 , 14 While it offers potential benefits, it is essential to consult a healthcare professional before using it and to be aware of potential side effects. 8 , 15

Literature analysis of 16 papers
Positive Content
10
Neutral Content
1
Negative Content
5
Article Type
7
1
1
0
16
1.

The effects of acetazolamide on the ventilatory response to high altitude hypoxia.

Author: BurkiN K, KhanS A, HameedM A

AMS symptom relief
Improved oxygenation

Acetazolamide, a carbonic anhydrase inhibitor, improved oxygenation in subjects exposed to acute high altitude. While it did not affect CO2 chemosensitivity, it increased ventilation and oxygenation at high altitude.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Comparison of the effects of acetazolamide and aminophylline on apnea incidence and on ventilatory response to CO2 in preterm infants.

Author: CordobaE, GerhardtT, RojasM, DuaraS, BancalariE

Augments ventilatory response
Reduced apnea frequency
Decreased pH

Acetazolamide reduced sleep apnea in preterm infants, but did not significantly improve the ventilatory response to CO2. Aminophylline effectively reduced apnea frequency with no significant change in the ventilatory response to CO2.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Acetazolamide affects performance on the Nagel II anomaloscope.

Author: LeysM J, van SlyckenS, NorkT M, OdomJ V

Sensitivity loss reversible
Color vision sensitivity loss

Acetazolamide, a carbonic anhydrase inhibitor, alters the sensitivity of cone populations, particularly the carbonic anhydrase-containing cones. This sensitivity loss is reversible and not clinically significant but suggests that patients on acetazolamide should be excluded from studies comparing color vision in glaucomatous patients to normals.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

Side effects of acetazolamide: a systematic review and meta-analysis assessing overall risk and dose dependence.

Author: SchmicklChristopher N, OwensRobert L, OrrJeremy E, EdwardsBradley A, MalhotraAtul

Side effects

The risk of commonly reported side effects of acetazolamide (AZM) was estimated through meta-analyses. The study found that the risk of these side effects is dose-dependent.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

[Use of 0.1% dipivefrine chloride for treatment of patients with open angle glaucoma].

Author: Czechowicz-JanickaK, KamińskaE, StaszkiewiczJ

Glaucoma treatment

Dipivefrine chloride 0.1% eye drops significantly decreased intraocular pressure, especially in combination with 0.5% Oftensin. No significant differences were found in outflow facility compared with the foreign analogue of the drug.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Polish

7.

Effects of echothiophate on enzymatic hydrolysis of dipivefrin.

Author: AndersonJ A, RichmanJ B, MindelJ S

Echothiophate, a cholinesterase inhibitor, reversibly inhibited dipivefrin esterases in the cornea. This finding suggests that the two drugs can be used together safely.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Cicatricial entropion associated with chronic dipivefrin application.

Author: D'OstrophA O, DaileyR A

Entropion

Topical dipivefrin can cause cicatrization in the substantia propria of the conjunctiva leading to entropion.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Effects of topically applied 2% epinephrine and 0.1% dipivalyl epinephrine on the adrenergic nerves as revealed by histofluorescence.

Author: FlachA J, DonahueM E

Chemical sympathectomy

Epinephrine and dipivalyl epinephrine can result in chemical sympathectomy in rats.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

10.

[Effect of topical adrenergic agents on tissue circulation in human optic nerve head evaluated with a laser speckle microcirculation analyser].

Author: TamakiY, TomitaK, AraieM, TomidokoroA, NagaharaM

Increased tissue blood velocity

This study investigated the effects of carteolol and dipivefrine on tissue circulation in the human optic nerve head. A single instillation of carteolol significantly increased tissue blood velocity in the optic nerve head, while dipivefrine did not have a significant effect. Both drugs reduced intraocular pressure. These results suggest that carteolol may improve blood flow to the optic nerve head, while dipivefrine has no effect on blood flow in this area.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Japanese

11.

Central vein thrombosis and topical dipivalyl epinephrine.

Author: FledeliusH C

Central vein thrombosis

A possible association between dipivalyl epinephrine, an eye drop used to treat glaucoma, and central vein thrombosis in the eye was reported in a single case.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Effects of dipivefrin and pilocarpine on pupil diameter, automated perimetry and LogMAR acuity.

Author: EdgarD F, CrabbD P, RudnickaA R, LawrensonJ G, GuttridgeN M, O'BrienC J

Adverse effects on visual field
Reduced acuity

Dipivefrin caused mydriasis but did not affect visual fields or acuity. Pilocarpine had negative effects on visual fields and acuity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

A single-blind randomised trial comparing adrenaline 1.0% with dipivalyl epinephrine (propine) 0.1% in the treatment of open-angle glaucoma and ocular hypertension.

Author: MillsK B, JacobsN A

Reduced intraocular pressure
Side effects

Both adrenaline 1% and dipivalyl epinephrine (Propine) 0.1% lowered intraocular pressure in patients with open-angle glaucoma and ocular hypertension. However, the effect was not significant enough to warrant their use as a first-line treatment. Side effects were reported in 60% of patients receiving Propine and 66% of those receiving adrenaline.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

A double-masked comparison of betaxolol and dipivefrin for the treatment of increased intraocular pressure.

Author: AlbrachtD C, LeBlancR P, CruzA M, LampingK A, SiegelL I, SternK L, KelleyE P, StoeckerJ F

Treats glaucoma
Burning
Stinging

Betaxolol (0.5%), a cardioselective beta-adrenoceptor antagonist, and dipivefrin (0.1%), an alpha/beta-adrenergic agonist, were equally effective in reducing intraocular pressure. Both treatments caused similar minor heart rate increases, but betaxolol caused significantly more stinging or burning.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Cystoid macular edema associated with latanoprost therapy in a case series of patients with glaucoma and ocular hypertension.

Author: MoroiS E, GottfredsdottirM S, SchteingartM T, ElnerS G, LeeC M, SchertzerR M, AbramsG W, JohnsonM W

Cystoid macular edema

This study found a possible association between latanoprost and cystoid macular edema (CME) in patients with coexisting ocular conditions that may have placed their eyes at risk for prostaglandin-mediated blood-retinal barrier vascular insufficiency.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Timolol and dipivalyl epinephrine combination therapy.

Author: McGuinnessR, FrumarK D

Controls intraocular pressure
DPE sensitivity

Combination therapy with timolol and dipivalyl epinephrine is an effective and well-tolerated treatment for glaucoma and ocular hypertension.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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