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Comparison of the combinations of fexofenadine-pseudoephedrine and loratadine-montelukast in the treatment of seasonal allergic rhinitis.

Author: BaroodyFuad M, MaleckarBarbara, MoinuddinRizwan, NaclerioRobert M, deTineoMarcy

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Fexofenadine-pseudoephedrine and loratadine-montelukast had comparable efficacy in treating seasonal allergic rhinitis.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Antihistamine-decongestant combinations are used routinely for the treatment of seasonal allergic rhinitis. Recently, the combination of an antihistamine and a leukotriene receptor antagonist has been shown to be efficacious. OBJECTIVE: To compare the 2 combinations in the treatment of ...See full text at original site
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引用元：
https://doi.org/10.1016/S1081-1206(10)61713-9

データ提供：米国国立医学図書館（NLM）

Comparing Treatment Strategies for Seasonal Allergic Rhinitis

This study compares two commonly used treatment combinations for [seasonal allergic rhinitis]. The researchers compared the efficacy of [fexofenadine-pseudoephedrine] versus [loratadine-montelukast] in alleviating symptoms and improving quality of life in patients with seasonal allergic rhinitis. The study aimed to provide a head-to-head comparison of these treatment options and identify their potential benefits and limitations.

Comparable Efficacy for Seasonal Allergic Rhinitis Treatment

The study found that both treatment combinations demonstrated comparable efficacy in alleviating symptoms, improving [Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ)] scores, and reducing nasal obstruction in patients with seasonal allergic rhinitis. The study suggests that both fexofenadine-pseudoephedrine and loratadine-montelukast can be effective options for managing seasonal allergic rhinitis. However, the fexofenadine-pseudoephedrine group exhibited a lack of improvement in sleep symptoms, potentially due to the insomnia-inducing effects of pseudoephedrine.

Tailoring Treatment Strategies for Seasonal Allergic Rhinitis

The study's findings highlight the importance of considering individual patient needs when selecting treatment options for seasonal allergic rhinitis. While both treatment combinations demonstrated comparable overall efficacy, fexofenadine-pseudoephedrine's potential to disrupt sleep could necessitate alternative strategies for patients with sleep-related concerns. Further research is needed to identify potential strategies for mitigating the sleep-disrupting effects of pseudoephedrine while preserving its overall efficacy.

Dr.Camel's Conclusion

This study offers a valuable roadmap for navigating the complexities of seasonal allergic rhinitis treatment. By understanding the subtle differences in efficacy and potential side effects of these treatment options, we can better tailor treatment strategies to the unique needs of each patient, ultimately improving their quality of life during allergy season.

Date :
  1. Date Completed 2004-02-24
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

14756468

DOI: Digital Object Identifier

10.1016/S1081-1206(10)61713-9

Related Literature

Article Analysis
・Effects of fexofenadine and pseudoephedrine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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