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[Bacteriological evaluation of ofloxacin otic solution].

Author: DeguchiK, FukayamaS, IshiharaR, KoguchiM, OdaS, SuzukiK, SuzukiY, YokotaN

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

Ofloxacin otic solution was found to be effective against a wide range of organisms commonly associated with otitis media and external otitis. It demonstrated superior potency and a post-antibiotic effect compared to other otic solutions.
Paper Details　
Original Abstract of the Article :
Clinical trials of ofloxacin (OFLX) otic solution, such as an early phase II study, a dose-finding study, a phase III double-blind comparative study and open studies, were conducted in the period from February 1988 to October 1989. In these studies, organisms were isolated from secretions of middle ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1479686

データ提供：米国国立医学図書館（NLM）

Otic Solution for Otitis Media: A Comprehensive Look

The realm of [otology] is constantly seeking better treatments for [otitis media]. This research delves into the efficacy of [ofloxacin otic solution] as a potential solution. The study employed a multi-pronged approach, encompassing [clinical trials] to assess the drug's effectiveness. The researchers meticulously analyzed data from various phases of clinical trials, including [early phase II study, a dose-finding study, a phase III double-blind comparative study and open studies]. They discovered that [ofloxacin otic solution] demonstrated superior antimicrobial activity against a wide array of bacteria commonly associated with [otitis media] and [external otitis], including the notorious [Staphylococcus aureus] and [Pseudomonas aeruginosa]. These findings suggest that [ofloxacin otic solution] may be a promising therapeutic option for treating [otitis media] and [external otitis].

A Powerful Weapon Against Ear Infections

The study highlighted the potent antimicrobial properties of [ofloxacin otic solution]. It was found to be significantly more effective in inhibiting bacterial growth compared to other commonly used antibiotics, such as [cefmenoxime, fosfomycin, and fradiomycin]. These results offer compelling evidence for [ofloxacin otic solution] as a valuable tool in combating [otitis media] and [external otitis].

Keeping Otitis Media at Bay: A Comprehensive Approach

The findings suggest that [ofloxacin otic solution] possesses a unique combination of qualities that make it a strong contender for [otitis media] treatment. Its potent antibacterial activity, along with its ability to maintain effective concentrations in the ear canal, makes it a potential game-changer in managing this common ear infection. It’s always a good idea to consult with a healthcare professional to determine the best course of treatment for your specific needs.

Dr.Camel's Conclusion

This research shines a light on the potential of [ofloxacin otic solution] as a promising treatment for [otitis media] and [external otitis]. Like a desert oasis providing relief to weary travelers, this drug may provide a much-needed solution for those struggling with ear infections. The impressive antimicrobial activity and sustained concentration in the ear canal highlight its potential to effectively combat the bacteria causing these infections.

Date :
  1. Date Completed 1993-02-05
  2. Date Revised 2016-11-16
Further Info :

Pubmed ID

1479686

DOI: Digital Object Identifier

1479686

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Languages

Japanese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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