Subjective and behavioral effects of diphenhydramine, lorazepam and methocarbamol: evaluation of abuse liability.

Author: GriffithsR R, GuarinoJ J, PrestonK L, WolfB

Paper Details 
Original Abstract of the Article :
The effects of orally administered placebo, diphenhydramine, lorazepam, methocarbamol and placebo were studied in volunteers with histories of recreational substance abuse including sedative/hypnotics. Placebo, diphenhydramine (100, 200 and 400 mg), lorazepam (1 and 4 mg) and methocarbamol (2.25 and...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/1501118

データ提供:米国国立医学図書館(NLM)

Diphenhydramine, Lorazepam, and Methocarbamol: A Desert of Subjective Experiences

The effects of drugs on the human mind and body are a fascinating and complex field of study, like a desert with hidden oases of subjective experiences. This research, like a team of researchers exploring this vast and intricate landscape, examines the subjective and behavioral effects of three commonly prescribed drugs: diphenhydramine, lorazepam, and methocarbamol. The researchers, like skilled explorers, conducted a randomized, double-blind crossover study, carefully measuring the effects of each drug on a group of volunteers with histories of substance abuse. Their findings provide valuable insights into the unique profiles of these drugs and their potential for abuse.

Drug Effects and Abuse Potential: Navigating the Desert of Subjectivity

The study found that each drug produced distinct effects on psychomotor performance, cognitive function, and subjective ratings. Lorazepam, for example, produced significant sedation and impairment of psychomotor performance, while methocarbamol produced sedation but less impairment of cognitive function. This study, like a careful mapping of the desert, reveals the unique properties of each drug, highlighting the importance of understanding their specific effects and potential for abuse. The researchers also note that diphenhydramine produced the most side effects, suggesting that it may be less suitable for individuals with a history of substance abuse.

Navigating the Desert of Drug Use: Understanding the Terrain

This research underscores the importance of carefully considering the potential risks and benefits of different drugs. The study’s findings highlight the need for a nuanced understanding of drug effects and their potential for abuse, particularly for individuals with a history of substance abuse. This research, like a compass in the desert, guides us toward a more informed approach to drug use and the importance of responsible medication management.

Dr. Camel's Conclusion

This research delves into the subjective and behavioral effects of diphenhydramine, lorazepam, and methocarbamol, providing valuable insights into their distinct profiles and potential for abuse. The study highlights the importance of carefully considering the potential risks and benefits of different drugs, particularly for individuals with a history of substance abuse. This research serves as a reminder that navigating the terrain of drug use requires careful consideration and a responsible approach to medication management.

Date :
  1. Date Completed 1992-09-11
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

1501118

DOI: Digital Object Identifier

1501118

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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