Side Effects of methocarbamol: A Synthesis of Findings from 10 Studies

  1. Home
  2. Side Effects of methocarbamol
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of methocarbamol: A Synthesis of Findings from 10 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of methocarbamol: A Synthesis of Findings from 10 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Major Research Findings

Methocarbamol is a muscle relaxant used to relieve muscle spasms. Several studies have shown that methocarbamol is effective in the treatment of patients with various neurological disorders and skeletal muscle spasm states. 10 . However, methocarbamol has also been suggested to have abuse potential, especially at high doses. 8 . Furthermore, methocarbamol has been shown to impair psychomotor and cognitive performance less than other drugs such as lorazepam. 8 , 6 .

Reasons for Side Effects

Side effects of methocarbamol can be caused by the drug's action on the central nervous system. Methocarbamol works by inhibiting the function of neurotransmitters in the brain, resulting in muscle relaxation. However, this action can also cause side effects such as drowsiness, dizziness, and decreased alertness or concentration.

Common Side Effects

Drowsiness

One of the most common side effects of methocarbamol is drowsiness. 10 . Drowsiness can occur immediately after taking methocarbamol and usually improves by reducing the dosage.

Dizziness

Methocarbamol can also cause dizziness. 10 . Dizziness can occur immediately after taking methocarbamol and usually improves by reducing the dosage.

Decreased Alertness or Concentration

Methocarbamol can also cause decreased alertness or concentration. 10 . Decreased alertness or concentration can occur immediately after taking methocarbamol and usually improves by reducing the dosage.

Nausea

Methocarbamol can also cause nausea and vomiting. 10 . Nausea and vomiting can occur immediately after taking methocarbamol and usually improve by reducing the dosage.

Side Effects Management

Drowsiness

Drowsiness can occur immediately after taking methocarbamol. Therefore, avoid driving or operating machinery after taking methocarbamol.

Dizziness

Dizziness can occur immediately after taking methocarbamol. Therefore, get up slowly after taking methocarbamol.

Decreased Alertness or Concentration

Decreased alertness or concentration can occur immediately after taking methocarbamol. Therefore, avoid important tasks or dangerous activities after taking methocarbamol.

Nausea

Nausea can occur immediately after taking methocarbamol. Therefore, take methocarbamol with food.

Comparison between Studies

Commonalities between Studies

Several studies have shown that methocarbamol is effective in relieving muscle spasms. 10 , 9 . Methocarbamol is also considered a relatively safe drug. 10 , 9 .

Differences between Studies

The effectiveness of methocarbamol may vary between studies. 10 , 9 . Side effects of methocarbamol may also vary between studies. 10 , 9 .

Points to Note Regarding Application in Daily Life

Methocarbamol is considered an effective drug for relieving muscle spasms. However, methocarbamol can cause side effects such as drowsiness and dizziness. Therefore, avoid driving or operating machinery after taking methocarbamol. Additionally, follow your doctor's instructions when taking methocarbamol.

Limitations of Current Research

Research on methocarbamol is still insufficient. Therefore, further research is needed on the effectiveness and side effects of methocarbamol.

Directions for Future Research

Further research is needed on the effectiveness and side effects of methocarbamol. In particular, research on the long-term effectiveness and safety of methocarbamol is needed.

Conclusion

Methocarbamol is considered an effective drug for relieving muscle spasms. However, methocarbamol can cause side effects such as drowsiness and dizziness. Therefore, avoid driving or operating machinery after taking methocarbamol. Additionally, follow your doctor's instructions when taking methocarbamol.

Literature analysis of 10 papers
Positive Content
8
Neutral Content
1
Negative Content
1
Article Type
6
1
1
1
10
1.

Randomized-controlled trial of methocarbamol as a novel treatment for muscle cramps in cirrhotic patients.

Author: Abd-ElsalamSherief, ArafaMona, ElkadeemMahmoud, ElfertAsem, SolimanShaimaa, ElkhalawanyWalaa, BadawiRehab

Effective for cramps
Safe
Well tolerated
Drowsiness
Dry mouth

This study evaluated the efficacy and safety of methocarbamol in controlling muscle cramps in cirrhotic patients. Methocarbamol showed a significant decrease in the frequency and duration of cramps. Few side effects of methocarbamol were recorded, including dry mouth and drowsiness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Deep dry needling of trigger points located in the lateral pterygoid muscle: Efficacy and safety of treatment for management of myofascial pain and temporomandibular dysfunction.

Author: Gonzalez-PerezLuis-Miguel, Infante-CossioPedro, Granados-NunezMercedes, Urresti-LopezFrancisco-Javier, Lopez-MartosRicardo, Ruiz-Canela-MendezPablo

Improved function
Reduced pain
Drowsiness

Deep dry needling (DDN) of trigger points in the lateral pterygoid muscle (LPM) showed better efficacy in reducing pain and improving function than methocarbamol/paracetamol treatment in patients with chronic myofascial pain located in the LPM. No adverse events were observed with respect to DDN.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Muscle relaxants for pain management in rheumatoid arthritis.

Author: RichardsBethan L, WhittleSamuel L, BuchbinderRachelle

Pain management

Muscle relaxants are widely used as adjuncts in managing chronic musculoskeletal pain, but evidence supporting their effectiveness is limited.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Development of a nitric oxide-releasing analogue of the muscle relaxant guaifenesin for skeletal muscle satellite cell myogenesis.

Author: WangGuqi, BurczynskiFrank J, HasinoffBrian B, ZhangKaidong, LuQilong, AndersonJudy E

Muscle regeneration

This research developed a new nitric oxide (NO) donor, guaifenesin dinitrate (GDN), which was shown to promote satellite cell activation and proliferation in muscle tissue. This could have potential applications for treating muscle atrophy and promoting repair after injury.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Efficacy and safety of sodium hyaluronate in the treatment of Wilkes stage II disease.

Author: Oliveras-MorenoJose-Maria, Hernandez-PachecoEsther, Oliveras-QuintanaTeresa, Infante-CossioPedro, Gutierrez-PerezJose-Luis

Improved TMJ function
TMJ pain relief

This randomized controlled trial compared intra-articular (IA) infiltration of sodium hyaluronate (SH) with oral methocarbamol-paracetamol for treatment of temporomandibular joint (TMJ) pain in patients with Wilkes stage II disease. The SH group demonstrated significantly reduced pain at rest, pain on jaw opening, and pain on mastication compared to the control group. TMJ function was also significantly improved in the SH group. No adverse reactions were detected with SH.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Subjective and behavioral effects of diphenhydramine, lorazepam and methocarbamol: evaluation of abuse liability.

Author: PrestonK L, WolfB, GuarinoJ J, GriffithsR R

Side effects

Diphenhydramine, lorazepam, and methocarbamol, were tested in a crossover study in volunteers with histories of recreational substance abuse. Lorazepam produced the most significant subjective effects and impairment in psychomotor performance, while diphenhydramine caused the most side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

8.

Evaluation of the abuse potential of methocarbamol.

Author: PrestonK L, GuarinoJ J, KirkW T, GriffithsR R

Substance abuse potential

Methocarbamol, a muscle relaxant, had potential for abuse in individuals with a history of sedative/hypnotic abuse, although less than lorazepam. Both drugs impaired psychomotor and cognitive performance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

9.

A double-blind trial of methocarbamol versus placebo in painful muscle spasm.

Author: ValtonenE J

Muscle spasm relief
Side effects

Methocarbamol was more effective than placebo in treating patients with painful muscle spasm. Methocarbamol was effective in approximately 60% of patients compared to 30% of patients receiving placebo. Both groups experienced similar side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.