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Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20536 people with cerebrovascular disease or other high-risk conditions.

Author: , ArmitageJane, CollinsRory, ParishSarah, PetoRichard, SleightPeter

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

While cholesterol-lowering statin therapy has been shown to reduce the risk of stroke in previous randomized trials, large-scale prospective confirmation is needed.
Paper Details　
Original Abstract of the Article :
Lower blood cholesterol concentrations have consistently been found to be strongly associated with lower risks of coronary disease but not with lower risks of stroke. Despite this observation, previous randomised trials had indicated that cholesterol-lowering statin therapy reduces the risk of strok...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15016485

データ提供：米国国立医学図書館（NLM）

Simvastatin and Stroke Prevention: A Large-Scale Study

This study delves into the relationship between cholesterol-lowering therapy using simvastatin and the risk of stroke. The researchers conducted a large-scale prospective study involving over 20,000 individuals with cerebrovascular disease or other high-risk conditions. The primary objective was to investigate whether simvastatin, a statin medication known for its cholesterol-lowering effects, could effectively reduce the risk of stroke in this high-risk population. The study aimed to provide conclusive evidence to support or refute the potential benefits of simvastatin in stroke prevention.

Simvastatin's Potential Role in Stroke Prevention

This large-scale study provides compelling evidence that simvastatin therapy may be a valuable tool in stroke prevention. The researchers observed a significant reduction in the risk of stroke among patients who received simvastatin compared to those who did not. These findings contribute to the growing body of evidence supporting the use of statins in stroke prevention.

The Importance of Cholesterol Management in Stroke Prevention

This study reinforces the importance of maintaining healthy cholesterol levels for stroke prevention. The findings suggest that simvastatin therapy can be an effective strategy for managing cholesterol levels and reducing the risk of stroke. Just as a camel's ability to regulate its body temperature is crucial for survival in the desert, managing cholesterol levels is essential for maintaining cardiovascular health and reducing stroke risk.

Dr.Camel's Conclusion

This large-scale study provides compelling evidence that simvastatin therapy may be a valuable tool in stroke prevention. The findings emphasize the importance of cholesterol management for reducing stroke risk and highlight the potential of simvastatin as a key component in stroke prevention strategies. Just like a camel can navigate through the desert by seeking out oases, individuals can reduce their risk of stroke by taking steps to manage their cholesterol levels.
Date :
  1. Date Completed 2004-04-20
  2. Date Revised 2023-10-24
Further Info :

Pubmed ID

15016485

DOI: Digital Object Identifier

S0140673604156900

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・Effective treatment of cholesterol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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