Improvement of the ocular bioavailability of timolol by sorbic acid.

Author: HigashiyamaMasayo, InadaKatsuhiro, OhtoriAkira, TojoKakuji

Paper Details 
Original Abstract of the Article :
The ocular bioavailability of timolol increased in sorbic acid solution due to ion pair formation. Its octanol/water partition coefficient also increased, suggesting the formation of a more lipophilic complex. The concentration of timolol in rabbit aqueous humor was determined after instillation of ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/15019072

データ提供:米国国立医学図書館(NLM)

Timolol and Sorbic Acid: Improving Ocular Bioavailability

Timolol, a widely used medication for treating glaucoma, often faces a challenge in reaching its target site in the eye. Imagine a camel trying to cross a vast desert, where the wind carries sand and dust, obscuring the path ahead. This study explores a new approach to enhancing the delivery of timolol to the eye by using sorbic acid, a common preservative. The researchers investigated the interaction between timolol and sorbic acid, seeking to improve the bioavailability of timolol in the eye, much like finding a clearer path through the desert.

Enhanced Delivery: A Partnership for Improved Glaucoma Treatment

This study demonstrates the potential of using sorbic acid to improve the ocular bioavailability of timolol, a key medication for treating glaucoma. The researchers found that the presence of sorbic acid significantly increased the concentration of timolol in the aqueous humor, the fluid that nourishes the eye. This discovery could lead to more effective treatments for glaucoma and better outcomes for patients.

Ocular Health: Seeking Clearer Vision for a Better Future

This study highlights the importance of optimizing drug delivery for improved treatment outcomes. By enhancing the bioavailability of timolol in the eye, researchers are working towards more effective treatments for glaucoma, a debilitating eye condition that affects millions worldwide. The study encourages continued research into innovative drug delivery strategies, seeking to provide clearer vision and a better future for those struggling with vision impairments.

Dr.Camel's Conclusion

This research underscores the importance of optimizing drug delivery for improved treatment outcomes. By leveraging the partnership between timolol and sorbic acid, researchers have found a new pathway to enhance the bioavailability of this crucial medication for glaucoma. This study is a testament to the power of collaboration and the pursuit of innovative solutions in the field of ophthalmology. Just as a camel relies on its keen eyesight to navigate the desert, we strive for clearer vision and a better future for those facing vision challenges.

Date :
  1. Date Completed 2004-07-28
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

15019072

DOI: Digital Object Identifier

S0378517303006811

Related Literature

SNS
PICO Info
in preparation
Languages

English

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