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Cimetidine on-demand in dyspepsia. Experience with randomized controlled single-subject trials.

Author: DybdahlJ, FosstvedtD, JohannessenT, KlevelandP M, KristensenP, LøgeI, PetersenH

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Cimetidine, taken on-demand, showed a rapid symptom-relieving effect in patients with reflux- or ulcer-like non-ulcer dyspepsia, oesophagitis, and peptic ulcer.
Paper Details　
Original Abstract of the Article :
Double-blind randomized controlled trials in single subjects (N of 1 RCTs) have demonstrated a beneficial symptomatic effect of cimetidine in reflux- or ulcer-like non-ulcer dyspepsia (NUD). However, spontaneous fluctuations in symptoms reduce the validity of such trials when performed as continuous...See full text at original site
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引用元：
https://doi.org/10.3109/00365529208999947

データ提供：米国国立医学図書館（NLM）

Cimetidine On-Demand: A Personalized Approach to Dyspepsia

This study explored the effectiveness of cimetidine, a medication used to treat heartburn and ulcers, when taken on-demand for dyspepsia. The researchers conducted a series of single-subject trials to assess the drug's impact on symptoms in individuals with different gastrointestinal conditions.

Cimetidine: A Potential Solution for Dyspepsia

The study suggests that cimetidine taken on-demand can be effective in reducing symptoms of dyspepsia, including reflux-like and ulcer-like non-ulcer dyspepsia (NUD), peptic ulcer disease, and oesophagitis. However, the individual response to the drug varies, highlighting the need for personalized treatment approaches.

Managing Dyspepsia

Individuals experiencing dyspepsia should consult their doctor for a proper diagnosis and appropriate treatment plan. Lifestyle changes, such as avoiding triggers and making dietary modifications, can also play a role in managing symptoms.

Dr.Camel's Conclusion

This study demonstrates the potential of cimetidine as a treatment option for dyspepsia. It emphasizes the need for personalized treatment approaches and highlights the importance of individualized assessment to determine the optimal dosage and frequency of medication.
Date :
  1. Date Completed 1992-09-14
  2. Date Revised 2019-08-14
Further Info :

Pubmed ID

1502480

DOI: Digital Object Identifier

10.3109/00365529208999947

Related Literature

Article Analysis
・Effects of cimetidine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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