Effects of cimetidine: A Synthesis of Findings from 24 Studies

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Original Abstract of the Article

Main Research Findings

Cimetidine has been shown to be effective in treating peptic ulcers in multiple studies. 5 , 20 , 16 , 11 , 15 , 3 , 9 , 4 , 18 , 17 , 12 , 2 , 10 , 19 , 7 , 6 It has been reported to promote ulcer healing and alleviate symptoms by inhibiting gastric acid secretion. 1 Cimetidine has also been shown to be effective in preventing the recurrence of duodenal ulcers. 20 Additionally, cimetidine has been shown to reduce gastric mucosal damage caused by aspirin. 16 A new effervescent formulation of cimetidine has been shown to increase gastric pH more quickly than conventional formulations. 14 In some studies, cimetidine was found to be more effective than placebo. 5 , 15 , 3 , 9 , 2 , 7 , 6 , 19 However, some studies found no significant difference between cimetidine and placebo. 17

Benefits and Risks

Benefits Summary

Cimetidine can be a helpful medication for treating peptic ulcers, as it has the potential to accelerate ulcer healing and improve symptoms. 5 , 20 , 16 , 11 , 15 , 3 , 9 , 4 , 18 , 17 , 12 , 2 , 10 , 19 , 7 , 6 It also has the potential to prevent ulcer recurrence. 20 , 4 , 12 Furthermore, cimetidine has been shown to reduce gastric mucosal damage caused by aspirin. 16 Additionally, a new effervescent formulation has been suggested to increase gastric pH more quickly than conventional formulations. 14

Risks Summary

Cimetidine is generally considered a safe medication, but it can cause side effects in some individuals. 7 , 10 , 19 , 21 Reported side effects include headache, increased serum uric acid levels, and increased serum creatinine levels. 7 , 10 , 19 Cimetidine may also increase liver enzyme levels. 12 As cimetidine can interact with other medications, it is important to discuss its use with your doctor. 24

Comparison Between Studies

Similarities Between Studies

The common thread across these studies is that cimetidine appears to be effective in treating peptic ulcers. 5 , 20 , 16 , 11 , 15 , 3 , 9 , 4 , 18 , 17 , 12 , 2 , 10 , 19 , 7 , 6 It has been reported to promote ulcer healing and alleviate symptoms by inhibiting gastric acid secretion. 1 Cimetidine has also been shown to be effective in preventing the recurrence of duodenal ulcers. 20

Differences Between Studies

These studies vary in terms of cimetidine dosage, treatment duration, target conditions, and assessment methods. 5 , 20 , 16 , 11 , 15 , 3 , 9 , 4 , 18 , 17 , 12 , 2 , 10 , 19 , 7 , 6 As a result, it can be challenging to compare the findings. The effects of cimetidine may vary depending on the dosage and duration of treatment. 3 , 7 Additionally, the effects of cimetidine may vary depending on the patient's condition. 11 , 4 , 18 , 12 , 2 , 10 , 19 , 6

Consistency and Contradictions in the Results

While these studies suggest that cimetidine is effective in treating peptic ulcers, some studies did not find a significant difference between cimetidine and placebo. 17 This indicates that the effects of cimetidine may vary depending on factors such as dosage, treatment duration, target condition, and patient condition. 3 , 7 , 11 , 4 , 18 , 12 , 2 , 10 , 19 , 6 Additionally, some studies reported side effects associated with cimetidine. 7 , 10 , 19 , 21

Cautions for Applying the Results to Real Life

Cimetidine may be an effective medication for treating peptic ulcers, but it is essential to consult with a doctor before taking it. 5 , 20 , 16 , 11 , 15 , 3 , 9 , 4 , 18 , 17 , 12 , 2 , 10 , 19 , 7 , 6 Cimetidine can interact with other medications, so it is crucial to discuss its use with your doctor. 24 Additionally, cimetidine can cause side effects in some individuals. 7 , 10 , 19 , 21 If you experience any side effects, consult your doctor promptly.

Limitations of Current Research

These studies are generally small in scope, and they differ in their target conditions and assessment methods. 5 , 20 , 16 , 11 , 15 , 3 , 9 , 4 , 18 , 17 , 12 , 2 , 10 , 19 , 7 , 6 Therefore, it is difficult to generalize the findings. Additionally, these studies are all short-term, so there is limited information regarding long-term effects. 4 , 12 , 10 , 6

Directions for Future Research

To better understand the effects of cimetidine, larger-scale studies are needed. 5 , 20 , 16 , 11 , 15 , 3 , 9 , 4 , 18 , 17 , 12 , 2 , 10 , 19 , 7 , 6 Long-term effect studies are also essential. 4 , 12 , 10 , 6 Additionally, research is needed to better understand the side effects of cimetidine. 7 , 10 , 19 , 21

Conclusion

Cimetidine may be an effective medication for treating peptic ulcers. 5 , 20 , 16 , 11 , 15 , 3 , 9 , 4 , 18 , 17 , 12 , 2 , 10 , 19 , 7 , 6 However, it is important to consult with a doctor before taking cimetidine, as it can interact with other medications and may cause side effects in some individuals. 24 , 7 , 10 , 19 , 21 If you experience any side effects, consult your doctor promptly.

Literature analysis of 24 papers
Positive Content
23
Neutral Content
1
Negative Content
0
Article Type
24
0
0
0
24
1.

24-hour intragastric acidity and nocturnal acid secretion in patients with duodenal ulcer during oral administration of cimetidine and atropine.

Author: PounderR E, HuntR H, VincentS H, Milton-ThompsonG J, MisiewiczJ J

Effective gastric acid inhibition
No acute side effects

Cimetidine alone was effective in inhibiting gastric acid secretion. Combined treatment with atropine offered no advantages over cimetidine alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Cimetidine in patients with gastric ulcer: a multicentre controlled trial.

Author: FrostF, RahbekI, RuneS J, JensenK B, Gudmand-HoyerE, KragE, Rask-MadsenJ, WulffH R, GarbolJ, JensenK G, HojlundM, NissenV R

Gastric ulcer healing

Cimetidine (1 g/day) was more effective than placebo in healing gastric ulcers. After six weeks, 18 out of 23 patients on cimetidine experienced complete ulcer healing, compared to 6 out of 22 on placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Cimetidine versus intensive antacid therapy for duodenal ulcer: a multicenter trial.

Author: IppolitiA F, SturdevantR A, IsenbergJ I, BinderM, CamachoR, CanoR, CooneyC, KlineM M, KoretzR L, MeyerJ H, SamloffI M, SchwabeA D, StromE A, ValenzuelaJ E, WintroubR H

Duodenal ulcer healing
Pain relief
Diarrhea

Cimetidine (800 or 1200 mg daily) and an intensive regimen of Al-Mg antacid (210 ml daily) were found to have similar rates of duodenal ulcer healing and pain relief. After 4 weeks of treatment, 64% of patients on cimetidine (1200 mg), 59% on cimetidine (800 mg), and 52% on antacids experienced ulcer healing. While 80% of cimetidine-treated patients became asymptomatic by week 4, 63% of antacid-treated patients did so. No significant side effects were observed with cimetidine, but 27% of antacid-treated patients reported diarrhea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Long term cimetidine in the management of severe duodenal ulcer dyspepsia.

Author: GrayG R, SmithI S, MackenzieI, GillespieG

Prevention of duodenal ulcer relapse
Relapse after treatment discontinuation

Cimetidine (400 mg daily at bedtime) was significantly more effective than placebo in preventing duodenal ulcer relapse in patients who had previously experienced a remission. Only 27% of patients on cimetidine experienced relapse within 6 months, compared to 80% on placebo. No significant side effects were observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Cimetidine and placebo in the treatment of benign gastric ulcer: a multicenter double blind study.

Author: DyckW P, BelsitoA, FleshlerB, LiebermannT R, DickinsonP B, WoodJ M

Gastric ulcer healing
Reduced ulcer size
Effect may be obscured by antacids

Cimetidine was found to be more effective than placebo in healing gastric ulcers. However, the difference was not statistically significant.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Prophylactic effect of cimetidine in duodenal ulcer disease.

Author: Gudmand-HøyerE, JensenK B, KragE, Rask-MadsenJ, RahbekI, RuneS J, WulffH R

Prevention of duodenal ulcer relapse
No curative effect
Relapse after treatment discontinuation

Cimetidine (400 mg twice daily) was significantly more effective than placebo in preventing duodenal ulcer relapse in patients who had previously experienced a remission. Only 3 out of 26 patients on cimetidine experienced relapse within 12 months, compared to 20 out of 25 on placebo. No side effects were attributed to cimetidine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Comparison of two doses of cimetidine and placebo in the treatment of duodenal ulcer: a multicentre trial.

Author:

Symptomatic improvement
Ulcer healing
Headache
Increased serum creatinine
Increased serum uric acid

Cimetidine was effective in healing duodenal ulcers. In a double-blind multicentre trial, 61% of patients on 1 g cimetidine daily and 70% of patients on 2 g cimetidine daily showed complete ulcer healing after 4 weeks compared to 28% of those on placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

[Therapy of duodenal and prepyloric ulcers with cimetidine (author's transl)].

Author: HentschelE, SchützeK, HavelecL

Symptom reduction
Ulcer healing

Cimetidine was more effective than placebo in healing duodenal ulcers. In a double-blind randomized trial, 73% of patients on cimetidine showed complete ulcer healing after 4 weeks compared to 32% of those on placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

9.

Cimetidine in anastomotic ulceration after partial gastrectomy.

Author: FestenH P, LamersC B, DriessenW M, Van TongerenJ H

Anastomotic ulcer healing
Symptom relief
Ulcer relapse

Cimetidine is effective in healing anastomotic ulcers after partial gastrectomy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Controlled trial of maintenance cimetidine treatment in healed duodenal ulcer: short and long-term effects.

Author: DronfieldM W, BatchelorA J, LarkworthyW, LangmanM J

Effective relapse prevention
Frequent relapse
Potential for indefinite treatment

Cimetidine is effective in preventing relapse of duodenal ulcers. However, maintenance treatment may need to be continued indefinitely to prevent relapse.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Cimetidine and gastric ulcer healing: a double-blind controlled trial.

Author: LandeckerK D, CrawfordJ, HuntJ H, GillespieP, PiperD W

Accelerated ulcer healing

Cimetidine is effective in accelerating the healing of chronic gastric ulcers in ambulant patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Maintenance treatment of duodenal ulcer patients with a single bedtime dose of cimetidine.

Author: BerstadA, AadlandE, CarlsenE, MyrenJ, SembL S, Kruse-JensenA

Effective relapse prevention
Effective ulcer healing
Increased transaminases

Cimetidine is effective in healing duodenal ulcers and preventing relapse.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Cimetidine on-demand in dyspepsia. Experience with randomized controlled single-subject trials.

Author: JohannessenT, PetersenH, KristensenP, FosstvedtD, KlevelandP M, DybdahlJ, LøgeI

Effective for dyspepsia
Rapid symptom relief

Cimetidine, taken on-demand, showed a rapid symptom-relieving effect in patients with reflux- or ulcer-like non-ulcer dyspepsia, oesophagitis, and peptic ulcer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Effects of a new effervescent cimetidine formulation on gastric acidity in healthy subjects.

Author: VlasblomV, FellingerH W, BreumelhofR, SmoutA J

Prolonged effect
Reduced acidity

A new effervescent formulation of 800 mg cimetidine was more effective than a standard dose of Maalox in increasing intragastric pH and prolonging the effect for the entire 5-hour study period.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Cimetidine and placebo-cimetidine in the treatment of patients with chronic gastric ulcer (a multiclinical randomized double-blind comparative study).

Author: PattyI, TárnokF, DeákG, MózsikG

Better than placebo
Suitable for gastric ulcer

Cimetidine was effective in treating chronic gastric ulcer in 37 outpatients. While the healing rate was better than placebo, the difference was not statistically significant. Cimetidine was well tolerated and no side effects were observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Reduction of endoscopically assessed acute aspirin-induced gastric mucosal injury with cimetidine.

Author: KimmeyM B, SilversteinF E, SaundersD R, ChapmanR C

Reduced gastric mucosal injury

Cimetidine coadministered with aspirin reduced gastric mucosal injury. A 200-mg dose of cimetidine was effective in reducing mucosal injury compared to placebo (P<.001).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

17.

Gastric ulcer: a double-blind comparison of 100 mg pirenzepine plus antacid versus 800 mg cimetidine plus antacid.

Author: GonversJ J, RealiniS, BretholzA, VoirolM, ArnoldJ, BirchlerR, OllyoJ B, GuyotJ, CapitaineY

Gastric ulcer treatment
Mild side effects

Cimetidine and pirenzepine were equally effective in healing gastric ulcers. The most common side effects were mild and did not differ from those observed in other studies.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

18.

Duodenal ulcer healing by separate reduction of postprandial and nocturnal acid secretions have different pathophysiology.

Author: LamS K, LaiC L, NgM, FokK H, HuiW M

Effective duodenal ulcer treatment
Analgesic interference
Smoking interference

Cimetidine regimens designed to reduce postprandial and nocturnal acid secretions were compared in patients with duodenal ulcers. The standard regimen was most effective in healing ulcers, suggesting that reducing both mealtime and nighttime acid secretion is crucial.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

The relationship between active peptic ulcer, endoscopic duodenitis and symptomatic state after treatment with cimetidine.

Author: DanielssonA, EkB, NyhlinH, SteenL

Improved duodenitis
Symptomatic improvement
Ulcer healing
Increased serum creatinine

The study found that cimetidine was significantly more effective than placebo in healing peptic ulcers, with 82.6% of patients in the cimetidine group showing ulcer healing compared to 48.0% in the placebo group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Cimetidine treatment for the prevention of recurrence of duodenal ulcer: an international collaborative study.

Author: BurlandW L, HawkinsB W, BeresfordJ

Reduced ulcer recurrence
Few side effects

Cimetidine effectively reduces the recurrence of duodenal ulcers. It has few side effects and is well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Effect of cimetidine and antacid on gastric microbial flora.

Author: SneparR, PoporadG A, RomanoJ M, KobasaW D, KayeD

Increased gastric flora

Cimetidine, a drug used to treat ulcers, was found to increase microbial titers in the stomach, particularly mouth flora, compared to antacids. However, there was no significant difference in the overall microbial composition or titers between the two groups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Carbenoxolone maintenance in cimetidine-healed patients.

Author: GuslandiM, CambielliM, TittobelloA

Effective ulcer prevention

Carbenoxolone was more effective than cimetidine in preventing recurrence of duodenal ulcers. 21.4% of patients in the carbenoxolone group relapsed compared with 48.1% in the cimetidine group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Low-dose famotidine and effervescent cimetidine in healthy subjects: a placebo-controlled overnight pH study.

Author: ReillyT G, GrimleyC E, UsselmannB, CottrellJ, MannS G, RaskinS, NwokoloC U

Treats dyspepsia

This study compares the effects of famotidine 10 mg and cimetidine 200 mg on intragastric pH. Both medications increase intragastric pH, but cimetidine 200 mg in an effervescent formulation has a more rapid effect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers.

Author: ZhangYi-Fan, DaiXiao-Jian, YangYong, ChenXiao-Yan, WangTing, TangYun-Biao, TsaiCheng-Yuan, ChangLi-Wen, ChangYu-Ting, ZhongDa-Fang

Nemonoxacin pharmacokinetics
Cimetidine
Probenecid

Probenecid reduced the renal clearance and increased the plasma exposure of nemonoxacin by 22.6% and 26.2%, respectively, but these effects are unlikely to be clinically meaningful at therapeutic doses. Cimetidine had weaker effects on the pharmacokinetics of nemonoxacin, which are also unlikely to be clinically meaningful.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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