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Strategies to decrease viral load rebound, and prevent loss of CD4 and onset of resistance during structured treatment interruptions.

Author: BarasoloGabriele, CastelliFrancesco, D'AquilaRichard, FoliAndrea, LisziewiczJulianna, LoriFranco, MaggioloFranco, MaseratiRenato, MigliorinoMarco, PanAngelo, PaolucciStefania, ScudellerLuigia, TinelliCarmine, TomasoniLina

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Side effects and difficulties following treatment plans (adherence) can lead to people with HIV stopping their medication. This can cause a decrease in CD4 cells, the development of drug resistance, and a rapid increase in the amount of virus in the blood. However, carefully selecting medications and using structured treatment interruptions (STIs) may help reduce the risk of the virus increasing, maintain CD4 cell counts, and minimize drug resistance.
Paper Details　
Original Abstract of the Article :
Toxicity and other drug adherence-related factors have contributed to decreased compliance to antiretroviral regimens amongst HIV-infected patients. Irregular therapy disruption causes loss of CD4 T cells, onset of drug resistance and rapid rebound of plasma viral load (VL). However, an appropriate ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15040544

データ提供：米国国立医学図書館（NLM）

Strategies for Minimizing HIV Viral Load Rebound

This research delves into the intricate world of HIV treatment, where the constant battle against viral rebound is a challenging desert trek. The authors explore how irregular therapy disruption, caused by factors like toxicity and adherence issues, leads to the loss of CD4 T cells, drug resistance, and a resurgence of the virus. They propose a new approach: structured treatment interruptions (STIs) where strategically planned drug breaks can minimize viral rebound, preserve CD4 counts, and potentially reduce the emergence of drug resistance.

Finding the Right Rhythm in HIV Treatment

This research highlights the importance of tailoring HIV treatment regimens to individual needs and preferences. The authors emphasize that strategically timed drug breaks, or STIs, can be a valuable tool for managing HIV, reducing viral rebound, and minimizing the emergence of drug resistance. These findings can help doctors create more personalized and effective treatment plans for HIV patients.

Navigating the Desert of HIV Treatment

For those living with HIV, this research offers a glimmer of hope. Like a well-placed oasis in the desert, STIs can provide a respite from constant medication while still effectively managing the virus. This research emphasizes the importance of communication between doctors and patients to find the best treatment approach for each individual.

Dr. Camel's Conclusion

This research offers a fresh perspective on HIV treatment. It's like finding a new pathway through the desert - a more efficient and patient-friendly approach to managing the virus. By carefully planning drug breaks, doctors can help patients navigate the challenges of HIV treatment with more success.

Date :
  1. Date Completed 2004-07-14
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15040544

DOI: Digital Object Identifier

15040544

SNS
PICO Info
in preparation
Languages

English

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