Tamoxifen and metabolite concentrations in serum and breast cancer tissue during three dose regimens in a randomized preoperative trial.

Author: DecensiAndrea, GjerdeJennifer, Guerrieri-GonzagaAliana, KisangaElton R, LienErnst A, PelosiGiuseppe, Pesci-FeltriAdriana, PigattoFrancesca, RobertsonChris, SerranoDavide

Paper Details 
Original Abstract of the Article :
Both therapeutic and adverse effects of tamoxifen may be related to its tissue concentrations. We investigated concentrations of tamoxifen, 4-hydroxytamoxifen, N-desmethyltamoxifen, and N-didesmethyltamoxifen in serum, normal breast, and breast cancer tissues during conventional dosage and two low-d...See full text at original site
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引用元:
https://doi.org/10.1158/1078-0432.ccr-03-0538

データ提供:米国国立医学図書館(NLM)

Tamoxifen: Exploring Its Concentrations in Serum and Breast Cancer Tissue

Tamoxifen, a widely used medication for treating breast cancer, exerts its effects by targeting specific receptors in the body. This research, a journey through the desert of breast cancer research, explores the concentrations of tamoxifen and its metabolites in serum and breast tissue. The researchers meticulously studied the levels of tamoxifen and its metabolites in various tissue compartments during different dose regimens, seeking to understand the relationship between drug concentrations and treatment outcomes. Their findings offer valuable insights into the pharmacokinetics of tamoxifen and its potential impact on breast cancer.

Understanding the Distribution of Tamoxifen in the Body

This study, a beacon of knowledge in the desert of breast cancer research, provides valuable insights into the pharmacokinetics of tamoxifen, revealing its distribution in different tissue compartments. The researchers' findings highlight the importance of considering drug concentrations in both serum and breast tissue when optimizing treatment strategies. This research encourages further investigation into the relationship between drug concentrations and treatment outcomes, seeking to refine our understanding of the mechanisms by which tamoxifen exerts its effects.

Navigating the Desert of Breast Cancer Treatment

This research underscores the importance of tailoring treatment approaches for breast cancer, considering individual patient factors and the potential for drug interactions. The study highlights the need for a comprehensive understanding of drug pharmacokinetics to optimize treatment strategies and improve patient outcomes. This research encourages us to embrace a personalized approach to breast cancer treatment, seeking to refine our understanding of drug action and develop tailored therapies that effectively target this complex disease.

Dr. Camel's Conclusion

This study provides valuable insights into the pharmacokinetics of tamoxifen, a crucial medication for treating breast cancer. The research highlights the importance of considering drug concentrations in both serum and breast tissue to optimize treatment strategies and improve patient outcomes. This study reminds us that the desert of breast cancer research is vast and ever-evolving, and we must continue our journey of discovery to find new ways to combat this disease and improve the lives of our patients.

Date :
  1. Date Completed 2004-12-16
  2. Date Revised 2019-11-08
Further Info :

Pubmed ID

15073109

DOI: Digital Object Identifier

10.1158/1078-0432.ccr-03-0538

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