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Effect of ozone exposure on airway responses to inhaled allergen in asthmatic subjects.

Author: BalmesJohn R, ChenLisa L, ChristianDorothy L, FerrandoRonald E, PedenDavid B, TagerIra B, WelchBarbara S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Controlled human exposure studies have yielded inconsistent results regarding the effect of ozone on early bronchoconstrictor responses to inhaled allergens in asthmatic subjects. This study highlights the need for further investigation into the airway inflammatory effects of ozone and allergens.
Paper Details　
Original Abstract of the Article :
Controlled human exposure studies have produced conflicting results regarding the effect of ozone on the early bronchoconstrictor response to inhaled allergen in specifically sensitized asthmatic subjects. Spirometric parameters do not necessarily reflect the airway inflammatory effects of inhaled o...See full text at original site
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引用元：
https://doi.org/10.1378/chest.125.6.2328

データ提供：米国国立医学図書館（NLM）

Ozone Exposure and Airway Responses in Asthma

This study examines the impact of ozone exposure on airway responses in asthmatic individuals. The authors investigate whether ozone exposure exacerbates the early bronchoconstrictor response to inhaled allergens in individuals with asthma.

The authors highlight the complex interplay between ozone exposure and airway responses in asthma. The study suggests that ozone exposure may not always lead to a clear and consistent increase in bronchoconstriction in response to inhaled allergens. However, the study emphasizes the importance of considering other factors, such as the severity of asthma and the individual's sensitivity to ozone, when assessing the impact of ozone exposure on airway health.

The Importance of Air Quality

This research underscores the importance of maintaining good air quality to protect the health of those with asthma. The study suggests that ozone exposure may contribute to airway inflammation and exacerbate asthma symptoms. This finding highlights the need for effective strategies to reduce air pollution and protect vulnerable populations.

Navigating the Complexities of Asthma

Asthma is a complex condition with a variety of triggers and contributing factors. This study underscores the importance of personalized care, tailored to individual needs and sensitivities. By understanding the nuances of asthma and its triggers, we can better manage the condition and improve the quality of life for those affected.

Dr.Camel's Conclusion

Like a desert mirage, ozone exposure can appear harmless but can have a detrimental impact on those with asthma. This study reminds us of the importance of understanding the factors that contribute to airway inflammation and the need to protect those with asthma from environmental triggers.

Date :
  1. Date Completed 2004-07-13
  2. Date Revised 2019-05-14
Further Info :

Pubmed ID

15189958

DOI: Digital Object Identifier

10.1378/chest.125.6.2328

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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