Effective treatment of asthma: A Synthesis of Findings from 54 Studies

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Original Abstract of the Article

Major Research Findings

These studies investigated the effectiveness of various medications, such as inhaled corticosteroids, beta-2 agonists, leukotriene antagonists, and anti-IgE antibodies, in treating asthma. Inhaled corticosteroids have been shown to be most effective in reducing asthma exacerbations. 25 Inhaled corticosteroids have also been shown to be the most effective in controlling asthma symptoms and improving lung function. 54 Long-acting beta-2 agonists can further reduce asthma exacerbations when used in addition to inhaled corticosteroids. 25 Leukotriene antagonists are not as effective as inhaled corticosteroids, but can reduce asthma exacerbations. 25 Anti-IgE antibodies can reduce asthma exacerbations in patients with allergic asthma. 40 However, anti-IgE antibodies are not effective for all asthma patients. 40

Benefits and Risks

Benefits Summary

These studies suggest that various medications, such as inhaled corticosteroids, beta-2 agonists, leukotriene antagonists, and anti-IgE antibodies, are effective in controlling asthma symptoms, improving lung function, and reducing asthma exacerbations in asthma treatment.

Risks Summary

Inhaled corticosteroids can cause some side effects, such as growth suppression. 47 Beta-2 agonists can cause side effects such as palpitations, tremors, and headaches. 22 Leukotriene antagonists are generally safe medications, but side effects can occur in rare cases. 20 Anti-IgE antibodies can cause some side effects, such as injection site reactions. 40

Comparison of Studies

Commonalities of Studies

All of these studies show that inhaled corticosteroids are effective in the treatment of asthma. 54 47 16 Also, all these studies suggest that beta-2 agonists are effective in controlling asthma symptoms and improving lung function when used in addition to inhaled corticosteroids. 17 9

Differences in Studies

These studies have different subjects, study periods, and methods, so there are differences in the results. For example, one study showed that inhaled corticosteroids may affect growth. 47 However, another study showed that inhaled corticosteroids do not affect growth. 52 Also, one study showed that leukotriene antagonists are not as effective as inhaled corticosteroids. 25 However, another study showed that leukotriene antagonists have an effect similar to that of inhaled corticosteroids. 20

Consistency and Contradictions of Results

These studies show that inhaled corticosteroids are the most effective in controlling asthma symptoms, improving lung function, and reducing asthma exacerbations. 54 47 16 However, inhaled corticosteroids can cause some side effects, such as growth suppression. 47 Beta-2 agonists can also cause side effects such as palpitations, tremors, and headaches. 22 The effectiveness and side effects of other medications may vary depending on the research results.

Considerations for Applying Results to Real Life

Asthma treatment varies from patient to patient. Therefore, it is important to be cautious when applying these research results to real life. It is important to follow your doctor's instructions and treat your asthma according to your symptoms.

Limitations of Current Research

These studies have some limitations. For example, not all studies use the same types of medications. Also, not all studies use the same research methods. Therefore, care must be taken when comparing and interpreting these research results.

Future Research Directions

Further research on asthma treatment is needed. In particular, research needs to be conducted on the long-term effects of inhaled corticosteroids and the development of new treatments.

Conclusion

These studies suggest that various medications, such as inhaled corticosteroids, beta-2 agonists, leukotriene antagonists, and anti-IgE antibodies, are effective in treating asthma. However, these medications can cause side effects. It is important to follow your doctor's instructions and treat your asthma according to your symptoms.

Keywords
Benefit Keywords
Asthma treatment
1
Beneficial effects of corticosteroids
Minimal side effects of short courses
2
Airflow obstruction treatment
Improved quality of life
4
Safe for nonasthmatic subjects
5
Improved lung function
Reduced hospital admissions
6
Anti-inflammatory effects
Asthma treatment
7
Improved lung function
Reduced bronchial inflammation
8
Asthma control
9
Reduced exercise-induced asthma
10
Improved asthma knowledge
11
Improved acute asthma treatment
12
Improved asthma control
Reduced beta2-agonist use
13
Treat COPD
14
Asthma prevention
Asthma treatment
BHR relief
15
Effective treatment of asthma
16
Improves voice
18
Improved asthma knowledge
19
Improved asthma control
20
Asthma control
Lung function
21
Bronchodilation
22
Asthma treatment
23
Decreased eosinophils
Decreased symptoms
Improved lung function
24
Reduced asthma exacerbations
25
No adrenal suppression
Reduces airway inflammation
27
Control asthma
28
Asthma treatment
29
Asthma treatment
30
Controls symptoms
Enhances efficacy of corticosteroids
31
Asthma treatment
32
Improved asthma control
Rapid onset of action
Reduced cortisol suppression
33
Asthma treatment
Improved well-being
34
Allergic asthma treatment
Improved quality of life
Reduced inflammation
35
Improved asthma control
Reduced exacerbations
37
Asthma treatment
38
Asthma control
Steroid reduction
39
Improved asthma control
Reduced exacerbations
Reduced medication need
40
Improved asthma control
41
Improved asthma prevention
42
Ameliorated symptoms
Improved lung function
43
Asthma control
Improved adherence
44
Improved small airway abnormalities
45
Asthma treatment
46
Asthma treatment
47
Improved asthma control
48
LAMA for asthma
49
Asthma exacerbation treatment
51
Improved asthma control
52
Asthma perception
Early medical attention
53
Asthma treatment
Improved lung function
54
Risk Keywords
Beta 2 agonist side effects
1
Asthma worsening
Early deterioration
3
No increase in side effects
Safe
6
Corticosteroid-induced side effects
16
Asthma death
Asthma exacerbations
Cardiac failure
Cardiovascular death
Headache
Ischemic heart disease
Near-fatal attacks
Palpitations
Tachyarrhythmias
Tachyphylaxis
Tremor
22
Bronchoconstriction
23
Tachycardia
Tremor
26
Long-term side effects
29
None reported
33
None reported
35
Increased asthma morbidity
36
Residual airway inflammation
41
Reduced growth
Throat infection
44
None
45
Growth effects
47
Gastrointestinal disturbance
Sleep disturbances
48
Asthma severity
50
Adverse events
51
Growth suppression
52
Iatrogenic effects
Overtreatment
53
Insufficient evidence for fixed airflow obstruction
54
Literature analysis of 54 papers
Positive Content
50
Neutral Content
1
Negative Content
3
Article Type
36
10
17
16
54
1.

Risks versus benefits of inhaled beta 2-agonists in the management of asthma.

Author: LipworthB J

Asthma treatment
Beta 2 agonist side effects

Asthma treatment aims to suppress inflammation with inhaled corticosteroids and relieve symptoms with bronchodilators. Lower doses of inhaled beta 2-agonists effectively dilate airways without systemic side effects, while higher doses may improve airway response for patients with severe obstruction but also cause systemic side effects. Regular use of inhaled beta 2-agonists may lead to increased bronchial hyperreactivity and require additional anti-inflammatory therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

[Glucocorticoids in asthmatic crisis in children].

Author: BidatE, ScheinmannP

Beneficial effects of corticosteroids
Minimal side effects of short courses

In 10 out of 12 double-blind randomized clinical trials since 1980, corticosteroids have been shown to be beneficial for acute asthma patients who do not respond completely to bronchodilators. Early high-dose short-term corticosteroid therapy is effective and has minimal, transient side effects. Frequent corticosteroid use for asthma should be reassessed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

3.

[Duration of the effect of inhaled corticosteroids on lung function and sensitivity of the respiratory tract in patients with bronchial asthma].

Author: MagnussenH, WillenbrockU, JörresR

Asthma worsening
Early deterioration

Patients with a high degree of bronchial hyperresponsiveness are more likely to show early deterioration of their clinical state after cessation of inhaled steroids.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : German

4.

Effects of high dose inhaled beclomethasone dipropionate, 750 micrograms and 1500 micrograms twice daily, and 40 mg per day oral prednisolone on lung function, symptoms, and bronchial hyperresponsiveness in patients with non-asthmatic chronic airflow obstruction.

Author: WeirD C, BurgeP S

Airflow obstruction treatment
Improved quality of life

Inhaled beclomethasone dipropionate (BDP) is an effective treatment for patients with chronic airflow obstruction not caused by asthma. Both objective and subjective measures show improvement. Unlike asthma, no improvement in bronchial responsiveness was detected after six weeks of treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

The effect of regular salbutamol on lung function and bronchial hyperresponsiveness in normal subjects and nonasthmatic atopic subjects with allergic rhinitis.

Author: Boothman-BurrellD, JonesD, HerbisonG P, TaylorD R

Safe for nonasthmatic subjects

Regular inhaled salbutamol did not cause adverse changes in lung function or bronchial hyperresponsiveness in normal or atopic subjects without asthma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Should inhaled anticholinergics be added to beta2 agonists for treating acute childhood and adolescent asthma? A systematic review.

Author: PlotnickL H, DucharmeF M

Improved lung function
Reduced hospital admissions
No increase in side effects
Safe

Adding multiple doses of inhaled anticholinergics to beta2 agonists in children and adolescents with severe asthma exacerbations reduced the risk of hospital admission by 30% and improved lung function. While single doses of anticholinergics also improved lung function, they did not reduce hospital admissions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

7.

Suppression of airway inflammation by theophylline in adult bronchial asthma.

Author: HoriguchiT, TachikawaS, KasaharaJ, DoiM, ShigaM, MiyazakiJ, SasakiY, HiroseM, ImazuM

Anti-inflammatory effects
Asthma treatment

This study discusses the role of chronic continuous airway inflammation caused by eosinophils in the pathophysiology of bronchial asthma. The study notes that theophylline, a conventionally used bronchodilator, may have anti-inflammatory effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Fluticasone propionate induced alterations to lung function and the immunopathology of asthma over time.

Author: FaulJ L, LeonardC T, BurkeC M, TormeyV J, PoulterL W

Improved lung function
Reduced bronchial inflammation

Inhaled fluticasone propionate (FP) improved both functional and immunopathological parameters of asthma. Short-term treatment improved lung function, while the impact of FP on bronchial inflammation was progressive, taking up to eight weeks.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Randomised trial of an inhaled beta2 agonist, inhaled corticosteroid and their combination in the treatment of asthma.

Author: HancoxR J, CowanJ O, FlanneryE M, HerbisonG P, McLachlanC R, WongC S, TaylorD R

Asthma control

This study aims to investigate the clinical effects of combining beta2 agonists and inhaled corticosteroids in treating asthma, specifically considering the potential for beta2 agonists to reduce the benefit of inhaled corticosteroids.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Nedocromil and exercise-induced asthma: acute and chronic effects.

Author: KivityS, OnnA, GreifY, FiremanE, PomeranzS, TopilskyM

Reduced exercise-induced asthma

Nedocromil sodium most likely reaches its maximal effect on exercise-induced asthma upon the first administration, although treatment for longer than 4 weeks might be required to prove a chronic effect of the drug.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Limited (information only) patient education programs for adults with asthma.

Author: GibsonP G, CoughlanJ, WilsonA J, HensleyM J, AbramsonM, BaumanA, WaltersE H

Improved asthma knowledge

This review focuses on the effects of limited asthma education, highlighting the importance of patient education in asthma management and its potential impact on knowledge and health outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Inhaled beta-agonists for asthma in mechanically ventilated patients.

Author: JonesA, RoweB, PetersJ, CamargoC, HammarquistC

Improved acute asthma treatment

This study addresses the use of inhaled bronchodilators for patients with acute severe asthma who are intubated and receiving ventilation, considering the established benefits of such treatments for spontaneously breathing individuals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

Effects of on-demand beta2-agonist inhalation in moderate-to-severe asthma. A randomized controlled trial.

Author: RichterB, BenderR, BergerM

Improved asthma control
Reduced beta2-agonist use

On-demand inhalation of short-acting beta2-agonists in moderate-to-severe asthma is safe and possible, with improved asthma control.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Additive effects of salmeterol and fluticasone or theophylline in COPD.

Author: CazzolaM, Di LorenzoG, Di PernaF, CalderaroF, TestiR, CentanniS

Treat COPD

Fluticasone propionate and salmeterol given together were more effective than salmeterol alone in improving lung function in patients with COPD. A randomized controlled trial involving 80 patients found that both treatments significantly improved lung function, with the combination therapy showing greater improvements than salmeterol alone. Furthermore, the combination therapy resulted in a greater improvement in lung function after salbutamol, suggesting a synergistic effect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

[Prophylactic and therapeutic effects of beclomethasone inhalation on bronchial hyperresponsiveness and asthma: a randomized, double-blind, parallel-group controlled trial].

Author: ZhengJ, ZhongN, WuZ

Asthma prevention
Asthma treatment
BHR relief

Beclomethasone dipropionate (BDP) inhalation significantly improved bronchial hyperresponsiveness (BHR) and symptoms in asthmatic students. BDP also prevented the development of asthma in students with asymptomatic BHR.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

16.

The effectiveness of high-dose inhaled budesonide therapy in the treatment of acute asthma exacerbations in children.

Author: NuhoğluY, BahçecilerN N, BarlanI B, Müjdat BaşaranM

Effective treatment of asthma
Corticosteroid-induced side effects

Guidelines recommend using corticosteroids to treat severe asthma attacks that don’t improve within 24-36 hours of home treatment. While this treatment is unlikely to cause serious problems for infrequent asthma attacks, frequent use can lead to side effects such as adrenal suppression, growth delays, and bone thinning.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Inhaled beta-agonists for asthma in mechanically ventilated patients.

Author: JonesA, RoweB, PetersJ, CamargoC, HammarquistC

While inhaled bronchodilators are effective for acute asthma in spontaneously breathing patients, their benefits for intubated and ventilated patients with severe asthma remain uncertain.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Inhaled beclomethasone dipropionate improves acoustic measures of voice in patients with asthma.

Author: BalterM S, AdamsS G, ChapmanK R

Improves voice

Inhaled beclomethasone dipropionate (BDP) improves specific acoustic measures of voice in patients with inadequately controlled asthma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Limited (information only) patient education programs for adults with asthma.

Author: GibsonP G, PowellH, CoughlanJ, WilsonA J, HensleyM J, AbramsonM, BaumanA, WaltersE H

Improved asthma knowledge

Patient education is a key part of asthma management, but while it can improve knowledge, its impact on health outcomes is uncertain. This review focuses on the effects of basic asthma education.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Effects of montelukast and beclomethasone on airway function and asthma control.

Author: IsraelElliot, ChervinskyPaul S, FriedmanBruce, Van BavelJulius, SkalkyCarol S, GhannamAsma F, BirdSteven R, EdelmanJonathan M

Improved asthma control

Montelukast was as effective as beclomethasone, as judged by indices of clinical control other than FEV(1) for asthma treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Comparisons of the complementary effect on exhaled nitric oxide of salmeterol vs montelukast in asthmatic children taking regular inhaled budesonide.

Author: BuchvaldFrederik, BisgaardHans

Asthma control
Lung function

This study compared the effects of salmeterol or montelukast on exhaled nitric oxide (FeNO) levels in asthmatic children who were already taking regular doses of inhaled corticosteroids. The study found that salmeterol was significantly more effective at reducing FeNO levels than either montelukast or placebo. Salmeterol also significantly improved lung function compared to placebo, while montelukast did not show significant improvement compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Adverse effects of beta-agonists: are they clinically relevant?

Author: AbramsonMichael J, WaltersJulia, WaltersE Haydn

Bronchodilation
Asthma death
Asthma exacerbations
Cardiac failure
Cardiovascular death
Headache
Ischemic heart disease
Near-fatal attacks
Palpitations
Tachyarrhythmias
Tachyphylaxis
Tremor

The study reviews the evidence for adverse effects associated with regular use of inhaled beta(2)-adrenoceptor agonists (beta(2)-agonists) in asthma management, focusing on potential risks of asthma deaths, exacerbations, and cardiovascular effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Effect of ozone exposure on airway responses to inhaled allergen in asthmatic subjects.

Author: ChenLisa L, TagerIra B, PedenDavid B, ChristianDorothy L, FerrandoRonald E, WelchBarbara S, BalmesJohn R

Asthma treatment
Bronchoconstriction

Controlled human exposure studies have yielded inconsistent results regarding the effect of ozone on early bronchoconstrictor responses to inhaled allergens in asthmatic subjects. This study highlights the need for further investigation into the airway inflammatory effects of ozone and allergens.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

24.

Induced sputum in children with newly diagnosed mild asthma: the effect of 6 months of treatment with budesonide or disodium cromoglycate.

Author: RytiläP, PelkonenA S, MetsoT, NikanderK, HaahtelaT, TurpeinenM

Decreased eosinophils
Decreased symptoms
Improved lung function

Sputum eosinophilia is present in children with newly diagnosed mild persistent asthma. Inhaled budesonide, but not disodium cromoglycate, decreases sputum eosinophils and improves clinical and functional outcomes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Pharmacological management to reduce exacerbations in adults with asthma: a systematic review and meta-analysis.

Author: SinDon D, ManJonathan, SharpeHeather, GanWen Qi, ManS F Paul

Reduced asthma exacerbations

This review assessed the long-term effects of various asthma medications on exacerbations in adults with chronic asthma. The review found that inhaled corticosteroids were the most effective therapy for reducing exacerbations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

[Different inhaler devices in acute asthma attacks: a randomized, double-blind, placebo-controlled study].

Author: Chong NetoHerberto J, Chong-SilvaDébora C, MaraniDaniele M, KurodaFlávia, OlandoskyMárcia, NoronhaLúcia de

Tachycardia
Tremor

A study comparing different inhaler devices for treating acute asthma attacks found no difference in efficacy between nebulizer, metered-dose inhaler with spacer, homemade spacer, and dry powder inhaler. However, the nebulizer and homemade spacer caused more side effects and were more expensive.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Portuguese

27.

Ciclesonide, a novel inhaled steroid, does not affect hypothalamic-pituitary-adrenal axis function in patients with moderate-to-severe persistent asthma.

Author: SzeflerStanley, RohatagiShashank, WilliamsJames, LloydMark, KunduSudeep, BanerjiDonald

No adrenal suppression
Reduces airway inflammation

This study found that treatment with moderate and high doses of ciclesonide does not result in hypothalamic-pituitary-adrenal-axis suppression.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Adding salmeterol to an inhaled corticosteroid: long term effects on bronchial inflammation in asthma.

Author: KoopmansJ G, LutterR, JansenH M, van der ZeeJ S

Control asthma

Adding salmeterol, a long-acting beta2 agonist, to inhaled corticosteroids improves asthma control compared to increasing inhaled corticosteroid doses, but its long-term effects on the inflammatory process require further investigation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Nedocromil sodium for chronic asthma in children.

Author: SridharA V, McKeanM

Asthma treatment
Long-term side effects

This study highlights the need for further research on the long-term side effects of inhaled corticosteroids in treating chronic asthma in children, emphasizing the importance of long-term safety monitoring for this commonly used medication.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

30.

Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma.

Author: DeykinAaron, WechslerMichael E, BousheyHomer A, ChinchilliVernon M, KunselmanSusan J, CraigTimothy J, DiMangoEmily, FahyJohn V, KraftMonica, LeoneFrank, LazarusStephen C, LemanskeRobert F, MartinRichard J, PesolaGene R, PetersStephen P, SorknessChristine A, SzeflerStanley J, IsraelElliot,

Asthma treatment

The study discussed the complementary effects of long-acting beta-agonists (LABAs) and inhaled corticosteroids on asthma control, as well as the potential complementarity of LABAs and leukotriene receptor antagonists (LTRAs).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

The therapeutic effects of inhaled long-acting beta2-adrenergics (LABA) and corticosteroids (ICS) are not affected by their inhalation sequence in moderate/persistent asthma.

Author: Dal NegroR W, MichelettoC, TognellaS, TrevisanF, GuerrieroM

Controls symptoms
Enhances efficacy of corticosteroids

This study investigated the effectiveness of administering inhaled corticosteroids before or after a long-acting bronchodilator in moderate and severe persistent asthma, finding that the order of administration did not significantly impact the results.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

32.

Formoterol, montelukast, and budesonide in asthmatic children: effect on lung function and exhaled nitric oxide.

Author: Miraglia del GiudiceMichele, PiacentiniGiorgio L, CapassoMichele, CapristoCarlo, MaielloNunzia, BonerAttilio L, CapristoAngelo F

Asthma treatment

This study explores the combined effects of inhaled steroids, long-acting beta-agonists, and leukotriene antagonists on lung function and airway inflammation in children with moderate persistent asthma. The study aims to better understand how these common asthma medications work together in managing asthma, specifically focusing on the role of reducing inflammation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

33.

Similar efficacy of ciclesonide versus prednisolone to treat asthma worsening after steroid tapering.

Author: van den BergeM, ArshadS H, IndP W, MagnussenH, HamelmannE, KanniessF, PostmaD S

Improved asthma control
Rapid onset of action
Reduced cortisol suppression
None reported

Inhaled ciclesonide (800mug twice daily) was as effective as oral prednisolone (40mg once daily) in regaining asthma control in patients with asthma worsening, with a more rapid onset and smaller effect on cortisol suppression, suggesting a better safety profile.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

Effects of fluticasone propionate and salmeterol hydrofluoroalkane inhalation aerosol on asthma-related quality of life.

Author: EdinHeather M, AndersenLeslie B, SchoafLynne, Scott-WilsonCatherine A, HoShu-Yen, OrtegaHector G

Asthma treatment
Improved well-being

Current asthma guidelines emphasize the importance of considering how asthma affects a person's daily life and ability to function, in addition to assessing the severity of the condition. Effective asthma management should lead to improvements in both well-being and physical function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

35.

Clinical effects of purified air administered to the breathing zone in allergic asthma: A double-blind randomized cross-over trial.

Author: PedrolettiC, MillingerE, DahlénB, SödermanP, ZetterströmO

Allergic asthma treatment
Improved quality of life
Reduced inflammation
None reported

Clean air delivered directly to the breathing zone during sleep improved bronchial inflammation and quality of life in patients with perennial allergic asthma. Active treatment resulted in a mean miniAQLQ score improvement of 0.54 (p < 0.05) and significantly lower FeNO values (mean -6.95 ppb, p < 0.05).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

Bromotyrosines in sputum proteins and treatment effects of terbutaline and budesonide in asthma.

Author: van DalenChristine J, AldridgeRuth E, ChanTimothy, SenthilmohanRevathy, HancoxRobert J, CowanJan O, TaylorD Robin, TownG Ian, KettleAnthony J

Increased asthma morbidity

This study discussed the potential for short-acting beta2-agonists (SABAs) to downregulate the anti-inflammatory effects of inhaled corticosteroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

37.

Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma.

Author: KellyMargaret M, O'ConnorTerence M, LeighRichard, OtisJoceline, GwozdCarol, GauvreauGail M, GauldieJack, O'ByrnePaul M

Improved asthma control
Reduced exacerbations

This article discusses the limited data on whether combining inhaled corticosteroids with long-acting beta(2)-agonists affects airway remodeling in patients with asthma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

38.

Effects of extra-fine inhaled beclomethasone/formoterol on both large and small airways in asthma.

Author: ScichiloneN, BattagliaS, SorinoC, PaglinoG, MartinoL, PaternòA, SantagataR, SpataforaM, NicoliniG, BelliaV

Asthma treatment

This article discusses the importance of drug delivery to both large and small airways in the treatment of asthma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

39.

Steroid-sparing effects with allergen-specific immunotherapy in children with asthma: a randomized controlled trial.

Author: ZielenStefan, KardosPeter, MadoniniEnzo

Asthma control
Steroid reduction

Adding a mite allergoid subcutaneous immunotherapy (SCIT) to pharmacologic treatment was an effective and safe strategy to reduce corticosteroid doses while maintaining disease control in children with mite-induced allergic asthma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

40.

Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children.

Author: BusseWilliam W, MorganWayne J, GergenPeter J, MitchellHerman E, GernJames E, LiuAndrew H, GruchallaRebecca S, KattanMeyer, TeachStephen J, PongracicJacqueline A, ChmielJames F, SteinbachSuzanne F, CalatroniAgustin, TogiasAlkis, ThompsonKatherine M, SzeflerStanley J, SorknessChristine A

Improved asthma control
Reduced exacerbations
Reduced medication need

Omalizumab significantly reduced the number of days with asthma symptoms and the proportion of participants who had one or more exacerbations in inner-city children, adolescents, and young adults with persistent asthma. Omalizumab also reduced the need for inhaled glucocorticoids and long-acting beta-agonists.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

41.

Impact of add-on pranlukast in stable asthma; the additive effect on peripheral airway inflammation.

Author: YasuiHideki, FujisawaTomoyuki, InuiNaoki, KatoMasato, HashimotoDai, EnomotoNoriyuki, NakamuraYutaro, ShiraiToshihiro, SudaTakafumi, NakamuraHirotoshi, ChidaKingo

Improved asthma control
Residual airway inflammation

This study explored the potential additive effects of systemic therapy with pranlukast, an oral leukotriene receptor antagonist, to improve asthma control in patients already using inhaled corticosteroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

42.

Does outdoor air pollution induce new cases of asthma? Biological plausibility and evidence; a review.

Author: GowersAlison M, CullinanPaul, AyresJon G, AndersonH Ross, StrachanDavid P, HolgateStephen T, MillsInga C, MaynardRobert L

Improved asthma prevention

While air pollution is known to worsen asthma in those already affected, its role in causing new cases of asthma is less clear. While research suggests it's biologically possible, large-scale studies haven't found a strong link between overall air pollution levels and asthma rates in communities. However, smaller studies have found a potential link between asthma development and higher levels of air pollution near heavily trafficked roads, especially for those living close to these roads. The study concludes that while air pollution may contribute to some cases of asthma, its overall impact on public health is likely small compared to other factors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Smoking influences response to inhaled corticosteroids in patients with asthma: a meta-analysis.

Author: ZhengXueyan, GuanWeijie, ZhengJinping, YePing, LiuShan, ZhouJunhua, XiongYiquan, ZhangQionghua, ChenQing

Ameliorated symptoms
Improved lung function

Smoking significantly reduced the effectiveness of inhaled corticosteroids in patients with asthma, leading to decreased lung function, increased rescue medication use, and poorer overall control. Smoking cessation is essential for optimal asthma management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

44.

Ciclesonide versus other inhaled corticosteroids for chronic asthma in children.

Author: KramerSharon, RottierBart L, ScholtenRob J P M, BoluytNicole

Asthma control
Improved adherence
Reduced growth
Throat infection

Inhaled corticosteroids (ICS) are the most common treatment for asthma in children. However, there are concerns about potential side effects, such as slowed growth. Ciclesonide is a new type of ICS that may have fewer side effects and can be taken once a day, which may improve adherence.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

Effects of 24-week add-on treatment with ciclesonide and montelukast on small airways inflammation in asthma.

Author: NakajiHitoshi, PetrovaGuergana, MatsumotoHisako, IwataToshiyuki, ItoIsao, OgumaTsuyoshi, InoueHideki, TajiriTomoko, NagasakiTadao, KanemitsuYoshihiro, NiimiAkio, MishimaMichiaki

Improved small airway abnormalities
None

Ciclesonide and montelukast add-on therapy to inhaled corticosteroids improved small airway abnormalities and asthma control in patients with stable asthma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

46.

Combination formoterol and budesonide as maintenance and reliever therapy versus combination inhaler maintenance for chronic asthma in adults and children.

Author: KewKayleigh M, KarnerCharlotta, MindusStephanie M, FerraraGiovanni

Asthma treatment

Asthma is a chronic lung condition with recurring episodes of wheezing, chest tightness, and coughing. Inhaled medications are often effective in controlling symptoms, preventing complications, and improving quality of life. While some medications are taken regularly and others for symptom relief, a single inhaler containing both a steroid and a bronchodilator is available (SiT or SMART therapy). This treatment may improve adherence to medication, reducing symptoms and exacerbations, but it's unclear whether it increases side effects from the steroid.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

47.

Inhaled corticosteroids in children with persistent asthma: effects on growth.

Author: ZhangLinjie, PrietschSílvio O M, DucharmeFrancine M

Asthma treatment
Growth effects

Inhaled corticosteroids (ICS) are the recommended initial treatment for persistent asthma in children. While ICS are generally safe, concerns remain about potential side effects from regular use, especially the effects on growth.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

48.

Effects of short-term oral corticosteroid intake on dietary intake, body weight and body composition in adults with asthma - a randomized controlled trial.

Author: BerthonB S, GibsonP G, McElduffP, MacDonald-WicksL K, WoodL G

Improved asthma control
Gastrointestinal disturbance
Sleep disturbances

Short-term oral corticosteroid (OCS) therapy did not significantly change appetite, dietary intake, body weight, or body composition in adults with stable asthma. However, other adverse effects such as sleep and gastrointestinal disturbance were more frequent during prednisolone treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

49.

Long-acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus the same dose of ICS alone for adults with asthma.

Author: AndersonDebbie E, KewKayleigh M, BoyterAnne C

LAMA for asthma

This research investigates the potential benefits of long-acting muscarinic antagonists (LAMAs) for treating asthma. Previous studies have shown promising results for LAMAs, but more research is needed to confirm their efficacy and determine the optimal place for LAMAs in asthma management.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

50.

Asthma severity, not asthma control, is worse in atopic compared with nonatopic adolescents with asthma.

Author: ArroyaveWhitney D, RabitoFelicia A, CarlsonJohn C, SeverMichelle L, LefanteJohn

Asthma severity

Atopic asthma was associated with worse asthma severity and higher fractional exhaled nitric oxide (FeNO) compared to nonatopic asthma, but not with control. Higher total IgE levels in all participants indicated worse severity and higher FeNO, suggesting a role of IgE in both asthma phenotypes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

51.

Different oral corticosteroid regimens for acute asthma.

Author: NormansellRebecca, KewKayleigh M, MansourGeorge

Asthma exacerbation treatment
Adverse events

This review examines the optimal dosing of oral steroids for asthma exacerbations to maximize recovery while minimizing potential side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Inhaled corticosteroids in children with persistent asthma: effects of different drugs and delivery devices on growth.

Author: AxelssonInge, NaumburgEstelle, PrietschSílvio Om, ZhangLinjie

Improved asthma control
Growth suppression

This review suggests that the type of inhaled corticosteroid (ICS) and delivery device used to treat children with persistent asthma may impact their growth. Fluticasone at an equivalent dose appeared to have less of a suppressive effect on growth compared to beclomethasone and budesonide. Easyhaler may have less of an adverse effect on growth compared to Turbuhaler when used to deliver budesonide. However, the evidence from this review is not certain enough to inform the selection of ICS or delivery device for children with persistent asthma. Further research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

53.

Symptoms and perception of airway obstruction in asthmatic patients: Clinical implications for use of reliever medications.

Author: BarnesPeter J, SzeflerStanley J, ReddelHelen K, ChippsBradley E

Asthma perception
Early medical attention
Iatrogenic effects
Overtreatment

Asthma causes the unpleasant sensation of breathlessness (dyspnea) caused by airway obstruction. Patients with poor perception of airway obstruction are at risk of delay in seeking medical attention and undertreatment, while those with heightened perception are at risk of overtreatment and iatrogenic adverse effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

54.

Does the use of inhaled corticosteroids in asthma benefit lung function in the long-term? A systematic review and meta-analysis.

Author: TanDaniel J, BuiDin S, DaiXin, LodgeCaroline J, LoweAdrian J, ThomasPaul S, JarvisDeborah, AbramsonMichael J, WaltersE Haydn, PerretJennifer L, DharmageShyamali C

Asthma treatment
Improved lung function
Insufficient evidence for fixed airflow obstruction

This study reviewed 13 randomized controlled trials and 11 observational studies and found that maintenance inhaled corticosteroids (ICS) were associated with modest improvements in long-term lung function in patients with mild asthma, particularly in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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