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Single and short-term dosing effects of levocetirizine on adenosine monophosphate bronchoprovocation in atopic asthma.

Author: GrayRobert D, LeeDaniel K C, LipworthBrian J, RobbFiona M, SoutarPatricia C, WilsonAndrew M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Levocetirizine, an antihistamine, was found to reduce bronchial hyper-responsiveness, a hallmark of asthma, in response to AMP challenge.
Paper Details　
Original Abstract of the Article :
Adenosine monophosphate (AMP) acts indirectly via primed airway mast cells to induce bronchial hyper-responsiveness, which in turn correlates with eosinophilic asthmatic inflammation and atopic disease expression. We evaluated single and short-term dosing effects of a modern histamine H1-receptor an...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884543/

データ提供：米国国立医学図書館（NLM）

The Impact of Levocetirizine on Bronchoprovocation in Atopic Asthma

This study delves into the fascinating world of atopic asthma, a condition characterized by airway inflammation and heightened sensitivity to allergens. It's like exploring a dusty desert oasis, uncovering hidden secrets about how the body reacts to triggers like pollen or dust. The research investigates the effects of levocetirizine, a common antihistamine, on bronchoprovocation, a test used to assess airway responsiveness. Think of it like a scientist studying a sandstorm, observing how the wind influences the movement of sand dunes. This research examines the role of levocetirizine in influencing the body's reaction to triggers.

Levocetirizine and Its Impact on Bronchial Responsiveness

The research examines the effects of single and short-term doses of levocetirizine on bronchial responsiveness, a key factor in atopic asthma. It reveals that levocetirizine, at clinically recommended doses, can influence the body's response to bronchoprovocation, a test used to assess airway responsiveness. This study helps unravel the complex interplay between antihistamines, bronchoprovocation, and atopic asthma.

Navigating Atopic Asthma: Management and Lifestyle Considerations

This study emphasizes the importance of understanding the triggers and management strategies for atopic asthma. It highlights the role of antihistamines like levocetirizine in managing symptoms and suggests the need for personalized treatment plans tailored to individual patient needs. Just as a camel navigates the challenges of the desert, individuals with atopic asthma can learn to manage their condition through a combination of medication, lifestyle modifications, and expert guidance.

Dr.Camel's Conclusion

This study provides a deeper understanding of the effects of levocetirizine on bronchoprovocation in atopic asthma. It highlights the importance of individualized treatment approaches and underscores the need for further research to fully comprehend the intricate mechanisms underlying this complex condition.
Date :
  1. Date Completed 2004-10-12
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

15206990

DOI: Digital Object Identifier

PMC1884543

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・Effects of levocetirizine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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