Effects of levocetirizine: A Synthesis of Findings from 21 Studies

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Original Abstract of the Article

Main Research Findings

Levocetirizine is an effective treatment for allergic rhinitis and chronic idiopathic urticaria. 11 Several studies have shown that levocetirizine is effective in reducing symptoms, improving quality of life, and reducing inflammation. 12 Levocetirizine has also been shown to be effective in suppressing histamine-induced nasal symptoms. 7 Levocetirizine is considered to be less sedating than cetirizine. 1 Levocetirizine is equally effective as cetirizine and loratadine in suppressing nasal and skin symptoms. 17 18 21 Levocetirizine has less effect on cognitive function and psychomotor performance compared to other antihistamines. 20 19 5 Levocetirizine may also be beneficial in improving diabetic nephropathy. 4

Benefits and Risks

Benefit Summary

Levocetirizine is an effective treatment for allergic rhinitis and chronic idiopathic urticaria. It has been shown to be less sedating than other antihistamines and has minimal effects on cognitive function and psychomotor performance. Levocetirizine may also be beneficial in improving diabetic nephropathy.

Risk Summary

While generally safe, levocetirizine may cause side effects such as drowsiness, headache, and dry mouth. 2 11

Comparison of Studies

Commonalities in Studies

Many studies show that levocetirizine is effective in treating symptoms of allergic rhinitis and chronic idiopathic urticaria. Levocetirizine has also been shown to be less sedating and have less effect on cognitive function and psychomotor performance compared to cetirizine and loratadine.

Differences in Studies

Levocetirizine has shown to be more effective in suppressing nasal symptoms when administered intranasally compared to orally. 7 Studies investigating the effects of levocetirizine on diabetic nephropathy are limited. 4

Consistency and Contradictions of Results

Many studies have shown that levocetirizine is effective in treating allergic rhinitis and chronic idiopathic urticaria, however, studies on sedative effects have reported contradictory results. Some studies show that levocetirizine is less sedating than cetirizine, while others have shown no difference. 1 2

Practical Implications

Levocetirizine can be a beneficial option for treating allergic rhinitis and chronic idiopathic urticaria but it is important to remember that it may still cause sedation. It is important to exercise caution when driving or operating machinery. 5 Always consult with a doctor before taking levocetirizine as it may interact with other medications.

Limitations of Current Research

Levocetirizine is a relatively new medication, so long-term safety and efficacy data are limited. Research on the effects of levocetirizine on diabetic nephropathy is also limited.

Future Directions for Research

Further research is needed to assess the long-term safety and efficacy of levocetirizine. More research is needed on the effects of levocetirizine on diabetic nephropathy. Research is also needed on dosage and administration methods of levocetirizine.

Conclusion

Levocetirizine is an effective medication for the treatment of allergic rhinitis and chronic idiopathic urticaria. It is less sedating and has less effect on cognitive function and psychomotor performance compared to other antihistamines. Levocetirizine is a good option for many patients as the risk of side effects is low. However, levocetirizine is still a relatively new medication and long-term safety and efficacy data are limited. Consult with your doctor before taking levocetirizine.

Literature analysis of 21 papers
Positive Content
20
Neutral Content
1
Negative Content
0
Article Type
14
4
2
2
21
1.

Comparison of the sedating effects of levocetirizine and cetirizine: a randomized, double-blind, placebo-controlled trial.

Author: TzanetosDouglas B, FahrenholzJohn M, ScottTheresa, BuchholzKristina

Tolerable for patients with sedation history
No significant difference in sedation compared to cetirizine

Levocetirizine was not found to be significantly less sedating than its parent drug cetirizine in patients who had previously reported sedation with cetirizine. The study suggests that many patients who perceive sedation with cetirizine might tolerate it if given in a masked manner.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

2.

Sedative Effects of Levocetirizine: A Systematic Review and Meta-Analysis of Randomized Controlled Studies.

Author: SnidvongsKornkiat, SeresirikachornKachorn, KhattiyawittayakunLikhit, ChitsuthipakornWirach

Allergy treatment
Sedative effects

This study investigated the sedative effects of levocetirizine. The study found that levocetirizine has modest sedative effects with a risk ratio of 1.67 when compared with placebo. The sedative effects observed for levocetirizine are not different from other second-generation antihistamines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

3.

Sedative Effects of Levocetirizine: A Systematic Review and Meta-Analysis of Randomized Controlled Studies.

Author: SnidvongsKornkiat, SeresirikachornKachorn, KhattiyawittayakunLikhit, ChitsuthipakornWirach

Allergy treatment
Sedative effects

This study investigated the sedative effects of levocetirizine. The study found that levocetirizine has modest sedative effects with a risk ratio of 1.67 when compared with placebo. The sedative effects observed for levocetirizine are not different from other second-generation antihistamines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Comparison of the effects of levocetirizine and losartan on diabetic nephropathy and vascular dysfunction in streptozotocin-induced diabetic rats.

Author: AnbarHanan S, ShehatouGeorge S G, SuddekGhada M, GameilNariman M

Ameliorated oxidative stress
Attenuated TNF-α and TGF-β1
Improved renal function
Reduced vascular hypertrophy
Restored NO bioavailability

This study found that levocetirizine, a histamine H1 receptor antagonist, improved renal function and attenuated oxidative stress in diabetic rats, comparable to or better than losartan. Levocetirizine also had superior vasculoprotective effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

A simulated car-driving study on the effects of acute administration of levocetirizine, fexofenadine, and diphenhydramine in healthy Japanese volunteers.

Author: InamiAkie, MatsudaRin, GroboschThomas, KomamuraHiroshi, TakedaKazuko, YamadaYusuke, MiyakeMasayasu, HiraokaKotaro, MaurerMarcus, YanaiKazuhiko, TashiroManabu

No sedative effects

This study evaluated the sedative effects of levocetirizine, a new-generation antihistamine, in healthy Japanese subjects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Evaluation of the antihistamine effects of olopatadine and levocetirizine during a 24-h period: a double-blind, randomized, cross-over, placebo-controlled comparison in skin responses induced by histamine iontophoresis.

Author: TakeoTomohiro, KasugaiChikatoshi, TanakaRui, AndoTakashi, OgawaAkina, AkitaYoichi, WatanabeDaisuke

Controls mild urticaria
Suppresses histamine response
Levocetirizine less potent
Levocetirizine may need additional dose

This study compared the antihistamine effects of olopatadine and levocetirizine in standard doses. Olopatadine completely suppressed histamine-induced wheal response for 24 hours, while levocetirizine's suppression decreased with time.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Comparison of effects of 5 and 10 mg oral desloratadine and levocetirizine on histamine-induced wheal and flare response in healthy volunteers.

Author: BulcaSongül, BayramgürlerDilek, Odyakmaz DemirsoyEvren, YavuzMelike, Sikar AktürkAysun, BilenNilgün, KıranRebiay

Allergic disease treatment
None reported

Levocetirizine 5 and 10 mg had a higher activity than desloratadine 5 and 10 mg in suppressing histamine-induced wheal and flare reactions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Comparison of the sedating effects of levocetirizine and cetirizine: a randomized, double-blind, placebo-controlled trial.

Author: TzanetosDouglas B, FahrenholzJohn M, ScottTheresa, BuchholzKristina

Tolerable for patients with sedation history
No significant difference in sedation compared to cetirizine

Levocetirizine was not found to be significantly less sedating than its parent drug cetirizine in patients who had previously reported sedation with cetirizine. The study suggests that many patients who perceive sedation with cetirizine might tolerate it if given in a masked manner.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

10.

Improving SAR symptoms with levocetirizine: evaluating active and placebo effects in pollen challenge vs. natural exposure studies.

Author: BoevR, SongD, BedenbaughA, HaeuslerJ-M

Reduce allergy symptoms

Levocetirizine is a drug used to treat allergies. This study investigated the efficacy of levocetirizine in reducing allergy symptoms in adult subjects with seasonal allergic rhinitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Levocetirizine in persistent allergic rhinitis and asthma: effects on symptoms, quality of life and inflammatory parameters.

Author: PasqualiM, BaiardiniI, RogkakouA, RiccioA M, GamaleroC, DescalziD, FolliC, PassalacquaG, CanonicaG W

Allergic rhinitis treatment
Improved QoL

Levocetirizine (LCZ) is an effective treatment for allergic rhinitis and improves quality of life in patients with asthma-rhinitis comorbidity. LCZ significantly reduced symptoms and improved quality of life scores compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Effects of levocetirizine as add-on therapy to fluticasone in seasonal allergic rhinitis.

Author: BarnesM L, WardJ H, FardonT C, LipworthB J

Adding an antihistamine to effective nasal steroid treatment for seasonal allergic rhinitis did not provide clinically significant benefits.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Comparison of the effects in the nose and skin of a single dose of desloratadine and levocetirizine over 24 hours.

Author: PassalacquaGiovanni, GuerraLaura, CompalatiEnrico, MassacanePierangela, RogkakouAnthi, ZanellaCristian, Baena-CagnaniRodrigo, CanonicaGiorgio Walter

Effective for allergic rhinitis
Side effects

Desloratadine and levocetirizine, two new antihistamines, were compared for their effects on the nose and skin over a 24-hour period. The study found no significant difference between the two drugs in terms of their effectiveness or safety.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Single and short-term dosing effects of levocetirizine on adenosine monophosphate bronchoprovocation in atopic asthma.

Author: LeeDaniel K C, GrayRobert D, WilsonAndrew M, RobbFiona M, SoutarPatricia C, LipworthBrian J

Bronchial hyper-responsiveness reduction

Levocetirizine, an antihistamine, was found to reduce bronchial hyper-responsiveness, a hallmark of asthma, in response to AMP challenge.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Comparative effects of desloratadine, fexofenadine, and levocetirizine on nasal adenosine monophosphate challenge in patients with perennial allergic rhinitis.

Author: LeeD K C, GardinerM, HaggartK, FujiharaS, LipworthB J

Attenuates nasal AMP response
Effective against allergic rhinitis

Desloratadine, fexofenadine, and levocetirizine are commonly used H1-antihistamines for allergic rhinitis. A study compared the effectiveness of these three drugs using nasal adenosine monophosphate (AMP) challenge in patients with perennial allergic rhinitis (PAR). All three antihistamines were found to be equally effective in attenuating the response to nasal AMP challenge, but more studies are needed to compare their long-term effects on symptoms, quality of life, and inflammation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Comparison of the effects of desloratadine and levocetirizine on histamine-induced wheal, flare and itch in human skin.

Author: DenhamK J, BoutsioukiP, CloughG F, ChurchM K

Desloratadine, an active metabolite of loratadine, is effective in reducing histamine-induced skin reactions. This study shows desloratadine's efficacy in healthy volunteers compared to levocetirizine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Acute and subchronic effects of levocetirizine and diphenhydramine on memory functioning, psychomotor performance, and mood.

Author: VersterJoris C, VolkertsEdmund R, van OosterwijckArmand W A A, AarabMounir, BijtjesSaskia I R, De WeertA Marit, EijkenErik J E, VerbatenMarinus N

Reduced sedation

Levocetirizine, a new antihistamine, was found to be free from sedative effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and weal and flare.

Author: HindmarchI, JohnsonS, MeadowsR, KirkpatrickT, ShamsiZ

Central nervous system effects

Levocetirizine, cetirizine, and loratadine are effective antihistamines with minimal effects on the central nervous system.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Comparison of the effects of levocetirizine and loratadine on histamine-induced wheal, flare, and itch in human skin.

Author: CloughG F, BoutsioukiP, ChurchM K

Histamine inhibition

Levocetirizine (5 mg) is a potent inhibitor of the effects of histamine in human skin, with efficacy exceeding that of loratadine (10 mg) when administered 4 h before testing.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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