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Thyroid blockade during a radiation emergency in iodine-rich areas: effect of a stable-iodine dosage.

Author: AoyagiKiyoshi, IshigakiJitsuro, IshigakiKatsu, MineMariko, NakamuraYoshihiro, TakamuraNoboru, YamashitaShunichi

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
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Overview

This study evaluated the effectiveness of stable iodine in blocking thyroid uptake of radioiodine in patients with hyperthyroidism. A single oral dose of 38 mg of iodide was found to be as effective as 76 mg in suppressing thyroid uptake. This suggests that the stable iodine dosage used for radiation emergencies in iodine-rich areas like Japan might need to be reevaluated.
Paper Details　
Original Abstract of the Article :
We examined the effect of stable iodine on thyroid gland blockade in patients with hyperthyroidism in order to make a preliminary evaluation of the appropriate dose of iodine prophylaxis in the event of a radiation emergency in Japan in which radioiodine is released to the environment. Eight patient...See full text at original site
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引用元：
https://doi.org/10.1269/jrr.45.201

データ提供：米国国立医学図書館（NLM）

Thyroid Blockade in Iodine-Rich Areas: A Critical Evaluation of Stable Iodine Dosage

Radiation emergencies, such as those involving the release of radioactive iodine, can pose significant threats to public health. Protecting the thyroid gland from radioactive iodine uptake is a critical aspect of emergency preparedness. This study examines the effectiveness of stable iodine in blocking thyroid uptake of radioactive iodine in patients with hyperthyroidism, focusing on the appropriate dosage in iodine-rich areas like Japan. Researchers administered single doses of stable iodine to patients with hyperthyroidism and monitored its impact on thyroid iodine uptake. Their findings indicate that a single dose of 38 mg of stable iodine effectively blocks thyroid uptake of radioactive iodine, suggesting that the current recommended dose in Japan may be reevaluated.

Optimizing Stable Iodine Dosage for Radiation Emergencies

The study demonstrates that a lower dose of stable iodine than currently recommended in Japan is effective in blocking thyroid uptake of radioactive iodine. This finding has important implications for emergency preparedness, potentially allowing for more efficient use of available resources.

Ensuring Safe and Effective Radiation Protection

The findings of this study highlight the importance of optimizing stable iodine dosage in radiation emergencies. By ensuring that the appropriate dose is used, we can maximize protection of the thyroid gland, reducing the risk of radiation-induced thyroid damage. Further research is needed to refine the optimal dosage and develop effective protocols for administering stable iodine in various populations and settings.

Dr. Camel's Conclusion

This research is like a camel caravan preparing for a journey through a desert storm, ensuring that they have the right supplies and strategies to stay safe. By adjusting the stable iodine dosage, we can strengthen our defenses against radiation emergencies, ensuring that we are adequately prepared to protect ourselves and our communities.

Date :
  1. Date Completed 2004-10-26
  2. Date Revised 2019-05-13
Further Info :

Pubmed ID

15304961

DOI: Digital Object Identifier

10.1269/jrr.45.201

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Languages

English

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