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Perioperative effects of melatonin and midazolam premedication on sedation, orientation, anxiety scores and psychomotor performance.

Author: AcilM, AyparU, BasgulE, CelikerV, DemirB, KaragözA H

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Melatonin premedication effectively reduces anxiety and provides sedation before surgery without impairing psychomotor performance after surgery.
Paper Details　
Original Abstract of the Article :
BACKGROUND AND OBJECTIVE: To compare the perioperative effects of melatonin and midazolam given in premedication, on sedation, orientation, anxiety scores and psychomotor performance. METHODS: Exogenous administration of melatonin not only facilitates the onset of sleep but also improves its qualit...See full text at original site
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引用元：
https://doi.org/10.1017/s0265021504007094

データ提供：米国国立医学図書館（NLM）

The Impact of Melatonin and Midazolam on Perioperative Sedation and Anxiety

The field of anesthesiology is like a vast desert, where we constantly seek ways to optimize patient comfort and safety during medical procedures. This research explores the effects of two commonly used premedications, melatonin and midazolam, on sedation, anxiety, and cognitive function before and after surgery. The authors aim to compare the efficacy of these premedications, offering valuable insights for anesthesiologists and surgeons.

Melatonin and Midazolam: A Comparative Study

This study compares the effects of melatonin and midazolam on sedation, anxiety, and neurocognitive performance in patients undergoing laparoscopic cholecystectomy. The study found that both melatonin and midazolam significantly increased sedation and reduced anxiety before surgery compared to placebo. However, while both premedications temporarily impaired neurocognitive performance, melatonin had a less pronounced effect on postoperative cognitive function.

Benefits of Melatonin Premedication

This study offers compelling evidence for the use of melatonin as a premedication for patients undergoing surgery. Melatonin's ability to reduce preoperative anxiety and sedation without significantly impairing postoperative cognitive function suggests its potential for improving patient comfort and recovery. The study's findings provide a valuable tool for anesthesiologists to optimize premedication strategies for surgical procedures.

Dr. Camel's Conclusion

This study offers a comprehensive exploration of the effects of melatonin and midazolam on perioperative sedation and anxiety. The findings suggest that melatonin may be a valuable premedication option for patients undergoing surgery due to its ability to reduce anxiety and improve sedation without significantly impairing cognitive function. This research highlights the importance of carefully considering premedication options to optimize patient care and improve surgical outcomes.

Date :
  1. Date Completed 2004-11-09
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

15318468

DOI: Digital Object Identifier

10.1017/s0265021504007094

SNS
PICO Info
in preparation
Languages

English

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