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Cardiovascular side effects of new antidepressants and antipsychotics: new drugs, old concerns?

Author: KecskemetiValeria, PacherPal

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This review discusses the cardiovascular effects of new antidepressants and antipsychotics, including SSRIs and newer antipsychotics. While these drugs are generally considered safer than older medications, they have been associated with cases of arrhythmias, prolonged QTc interval, and orthostatic hypotension. The review highlights the need for clinicians to be vigilant about these potential adverse reactions and to monitor ECG during therapy, especially in patients with cardiovascular disorders.
Paper Details　
Original Abstract of the Article :
The cardiovascular toxicity of older generation of tricyclic antidepressants (e.g. imipramine, desipramine, amitriptyline, clomipramine) and neuroleptics (e.g. haloperidol, droperidol, thioridazine, pimozide) is well established. These drugs inhibit cardiovascular Na(+), Ca(2+) and K(+) channels oft...See full text at original site
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引用元：
https://doi.org/10.2174/1381612043383872

データ提供：米国国立医学図書館（NLM）

Cardiovascular Effects of New Antidepressants and Antipsychotics: A Cautionary Tale

The vast desert of mental health treatment is constantly evolving, with new medications emerging to address the complexities of mood disorders and psychiatric conditions. This study explores the cardiovascular effects of newer generation antidepressants and antipsychotics, raising important questions about their safety.

The study aims to review the cardiovascular toxicity of older generation antidepressants and antipsychotics, comparing them to newer medications like selective serotonin reuptake inhibitors (SSRIs) and newer antipsychotics. The researchers examine the potential mechanisms by which these drugs might affect the heart and blood vessels.

Unforeseen Side Effects: A Hidden Sandstorm

The study found that while newer antidepressants and antipsychotics are often touted as having fewer side effects, there is growing evidence that they can also have significant cardiovascular effects. The study highlights cases of arrhythmias, prolonged QTc interval on electrocardiograms (ECG), and orthostatic hypotension associated with these newer drugs.

Navigating the Desert of Mental Health Treatment: A Guide for Patients

For individuals taking antidepressants or antipsychotics, this study emphasizes the importance of discussing potential cardiovascular risks with their healthcare provider. It is crucial to be aware of any possible side effects and to monitor for any changes in heart rhythm or blood pressure.

Dr. Camel's Conclusion

This study provides a cautionary tale about the potential cardiovascular effects of newer antidepressants and antipsychotics. It underscores the importance of ongoing monitoring and careful consideration of the risks and benefits of these medications. By navigating the vast desert of mental health treatment with vigilance and awareness, we can strive to ensure the safety and well-being of individuals seeking these therapies.
Date :
  1. Date Completed 2004-12-07
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

15320756

DOI: Digital Object Identifier

10.2174/1381612043383872

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Languages

English

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