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Continuous regional treatment with fluoropyrimidines for metastases from colorectal carcinomas: influence of modulation with leucovorin.

Author: EnckeA, HottenrottC, InglisR, LorenzM, MaierP, ReimannM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Regional hepatic treatment with 5-fluorodeoxyuridine (FUDR) and 5-fluorouracil (5FU) combined with leucovorin (LCV) demonstrated improved survival in patients with colorectal liver metastases. While the response rate varied and local side effects were common, median survival time increased after liver resection.
Paper Details　
Original Abstract of the Article :
Hepatic regional treatment represents an attempt to improve tumor response by increasing drug concentration with low systemic toxicities. Recently in vitro and clinical studies have shown that the cytotoxicity of 5-fluorodeoxyuridine (FUDR) and 5-fluorouracil (5FU) can be potentiated by high doses o...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1532672

データ提供：米国国立医学図書館（NLM）

Continuous Regional Treatment for Colorectal Cancer Metastases: A Journey Through the Desert of Cancer

In the vast and unforgiving desert of [colorectal cancer treatment], [regional therapy] offers a beacon of hope for patients with [liver metastases]. This study embarks on a journey to explore [the efficacy and impact of continuous regional treatment with fluoropyrimidines, specifically focusing on the modulation of treatment with leucovorin]. The authors meticulously examined [the clinical data of 221 patients] treated with [various forms of long-term monthly continuous regional treatment]. Their findings provide valuable insights into [the potential benefits and limitations of this approach].

Navigating the Shifting Sands of Treatment Options

The research demonstrates that [continuous regional treatment with fluoropyrimidines can improve survival times, particularly after liver resection], with a [median survival time of 36 months] observed in this cohort. The authors emphasize that [the response rate varies depending on factors such as the number of metastases, extent of infiltration, tumor volume, and extrahepatic disease].

The Oasis of Hope and the Challenges of Side Effects

While [regional treatment offers hope for patients with colorectal liver metastases], it's important to recognize [the potential side effects]. This study highlights [the importance of careful monitoring and management of local side effects, including biliary sclerosis and chemical hepatitis]. The authors acknowledge that [further randomized trials are necessary to compare regional treatment with systemic treatment options].

Dr.Camel's Conclusion

This research illuminates the complexities of [regional treatment for colorectal cancer metastases] and emphasizes the need for [continued research and individualized treatment strategies]. The authors' insights provide valuable guidance for clinicians in [navigating the challenges and maximizing the benefits of this approach].

Date :
  1. Date Completed 1992-05-01
  2. Date Revised 2018-05-24
Further Info :

Pubmed ID

1532672

DOI: Digital Object Identifier

0093-7754(92)90079-G

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Languages

English

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