Side Effects of floxuridine: A Synthesis of Findings from 29 Studies

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Original Abstract of the Article

Major Research Findings

Floxuridine is a fluoropyrimidine derivative used in the treatment of malignant tumors. This paper evaluated the efficacy and safety of floxuridine alone or in combination with radiation therapy in a multi-institutional trial. 10 . Floxuridine is also used in the treatment of colorectal cancer with liver metastasis, and it has been shown that the effect is more effective in combination with radiation therapy than single administration. 23 . In addition, floxuridine has been shown to be effective in the treatment of advanced breast cancer and ovarian cancer, and some studies have also investigated the effectiveness of combination therapy with floxuridine and other drugs. 21 25 8 6 5 . It has also been shown that adjusting the floxuridine administration schedule can increase the efficacy of the drug while reducing side effects. 19 26 .

Reasons for Side Effects

Side effects of floxuridine are caused by the drug's inhibition of cellular DNA synthesis. DNA synthesis is essential for cell proliferation, so floxuridine inhibits the growth of cancer cells, but it also inhibits the growth of normal cells, resulting in side effects.

Common Side Effects

Gastrointestinal

The most common side effects of floxuridine are gastrointestinal side effects. This is because the drug inhibits the proliferation of cells in the gastrointestinal tract. Specific side effects include diarrhea, nausea, vomiting, anorexia, and stomatitis. These side effects can worsen with increasing floxuridine doses. Diarrhea is one of the most common side effects of floxuridine administration and can be serious. 21 10 29 11 14 16 3 2 17 .

Hematologic

Floxuridine can also inhibit the proliferation of cells in the bone marrow, leading to a decrease in the number of white blood cells, red blood cells, and platelets. This can make the patient more susceptible to infections, anemia, or bleeding. 10 28 .

Neurological

Floxuridine can also affect the nervous system. Specific side effects include dizziness, headache, numbness, and sensory disturbances. 28 . In severe cases, the patient may experience altered consciousness or coma.

Skin

Floxuridine can also affect the skin. Specific side effects include rash, dry skin, and itching. 10 .

Liver

Floxuridine can also affect the liver. Specific side effects include liver function abnormalities and jaundice. Liver damage can worsen with increasing floxuridine doses. 22 . It has been reported that floxuridine administration may increase the fat content of the liver. 22 .

Countermeasures for Side Effects

Gastrointestinal

To reduce gastrointestinal side effects, dietary and drug therapy may be used. Dietary therapy involves eating easily digestible foods and avoiding irritants. Drug therapy includes the use of antiemetics, antidiarrheals, and prokinetics. Reducing the dose of floxuridine can also reduce side effects. 21 .

Hematologic

To reduce hematologic side effects, drugs called hematopoietic growth factors are used. Hematopoietic growth factors promote the proliferation of cells in the bone marrow, increasing the number of white blood cells, red blood cells, and platelets. 25 . Antibiotics may also be administered to prevent infection.

Neurological

Drug therapy is used to reduce neurological side effects. Specifically, antiemetics, analgesics, and anticonvulsants are used.

Skin

Moisturizers and steroid ointments are used to reduce skin side effects.

Liver

Drugs that aim to improve liver function are used to reduce liver side effects. Reducing the dose of floxuridine can also reduce side effects. If liver function deteriorates, floxuridine administration may need to be stopped. 22 .

Comparison of Studies

Commonalities of Studies

Multiple studies have shown that floxuridine is effective in the treatment of malignant tumors. In addition, it is common for side effects of floxuridine administration to be diverse, affecting the gastrointestinal tract, hematopoietic system, nervous system, skin, and liver.

Differences in Studies

There may be differences in efficacy and side effects between single administration and combination with other drugs. For example, when floxuridine is combined with radiation therapy, it has been shown to be more effective than single administration. 23 . In addition, combination therapy of floxuridine with other drugs may increase side effects. 21 25 8 6 5 .

Notes on Real-Life Application

Floxuridine is a drug used in the treatment of cancer. Therefore, it is very dangerous to take it or stop taking it without consulting a doctor. To prevent the occurrence and worsening of side effects, be sure to take it as directed by your doctor. In addition, floxuridine may interact with other drugs. If you are taking other medications, be sure to consult your doctor.

Limitations of Current Research

Research on floxuridine side effects is not yet sufficient. In particular, research on long-term side effects is lacking. In addition, although floxuridine is used for various types of cancer, side effects may vary depending on the type of cancer. Furthermore, individual constitution can also affect the incidence and severity of side effects.

Future Research Directions

To further elucidate the side effects of floxuridine, long-term safety research, comparative research on side effects in various types of cancer, and research on individual differences in side effects are needed in the future.

Conclusion

Floxuridine is an effective drug used in the treatment of malignant tumors, but it may cause a variety of side effects, affecting the gastrointestinal tract, hematopoietic system, nervous system, skin, and liver. To prevent the occurrence and worsening of side effects, it is important to take it as directed by your doctor. It is hoped that future research on the side effects of floxuridine will lead to the development of safer and more effective treatments.

Keywords
Benefit Keywords
Treats sexual desire disorder
1
Improved survival
3
Liver tumor treatment
Tumor marker decrease
4
Breast cancer treatment
5
Treat breast cancer
6
Effective treatment
7
Metastatic breast cancer treatment
Response rate increase
Survival prolongation
8
Liver cancer treatment
9
Tumor response
10
Partial response to metastases
11
Tumor regression
12
Tumor regression
13
Colon cancer treatment
14
HAI chemotherapy
Liver cancer treatment
15
Gastric cancer treatment
16
Colorectal cancer treatment
17
Safe and effective for meningeal tumors
18
Cancer treatment
19
Breast cancer recurrence treatment
20
Cancer response
Improved performance
Pain relief
21
Good tolerability
Improved survival
Tumor response
23
cancer treatment
24
Breast cancer treatment
25
Treat cancer
26
Breast cancer treatment
Liver metastasis control
27
Cancer treatment
28
Cancer treatment
Tumor response
29
Risk Keywords
Hypotension risk
Sedation risk
Syncope risk
1
Adjuvant treatment morbidity
Liver metastasis relapse
2
Biliary sclerosis
Chemical hepatitis
Diarrhea
Stomatitis
3
Abdominal pain
Acute gastritis
Fever
Nausea
Vomiting
4
Diarrhea
Moon face
5
Side effects
7
Limited response
Regional side effects
Short survival
9
Diarrhea
Dysphagia
Impaired general condition
Leukocytopenia
Radiation dermatitis
10
Anorexia
Diarrhea
11
Gastrointestinal side effects
13
Catheter complications
Ulcers
15
Diarrhea
16
Biliary toxicity
Systemic side effects
17
Headache
Nausea
18
Diarrhea
Mucositis
19
Headache
Nausea
Stomatitis
20
Diarrhea
Dose reduction
Leg edema
Obesity
Venous thrombosis
21
Hepatic steatosis
22
Leukopenia
Malaise
Nausea
Peripheral neuropathy
25
Toxicity
26
Alopecia
Bone marrow depression
Gastrointestinal disturbance
27
Myelotoxicity
Neurotoxicity
Stomatitis
28
Gastrointestinal side effects
29
Literature analysis of 29 papers
Positive Content
24
Neutral Content
1
Negative Content
4
Article Type
2
0
0
4
29
1.

Effects of Timing of Flibanserin Administration Relative to Alcohol Intake in Healthy Premenopausal Women: A Randomized, Double-Blind, Crossover Study.

Author: SimonJames A, ClaytonAnita H, KingsbergSheryl A, ParishSharon J, KimNoel N, MillheiserLeah

Treats sexual desire disorder
Hypotension risk
Sedation risk
Syncope risk

Flibanserin is approved for treating acquired, generalized, hypoactive sexual desire disorder in premenopausal women. Sedation is a common side effect, and while infrequent, hypotension and syncope are safety concerns due to potential interactions with alcohol.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

[Results of resection and adjuvant therapy of liver metastases of primary colorectal tumors--a review of the literature].

Author: LorenzM, Staib-SeblerE, RossionI, KochB, GogC, EnckeA

Adjuvant treatment morbidity
Liver metastasis relapse

The results of adjuvant treatment after resection of colorectal liver metastases were evaluated in 340 patients.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

3.

Continuous regional treatment with fluoropyrimidines for metastases from colorectal carcinomas: influence of modulation with leucovorin.

Author: LorenzM, HottenrottC, MaierP, ReimannM, InglisR, EnckeA

Improved survival
Biliary sclerosis
Chemical hepatitis
Diarrhea
Stomatitis

Regional hepatic treatment with 5-fluorodeoxyuridine (FUDR) and 5-fluorouracil (5FU) combined with leucovorin (LCV) demonstrated improved survival in patients with colorectal liver metastases. While the response rate varied and local side effects were common, median survival time increased after liver resection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

[Successful treatment of disseminated breast cancer with combination therapy of 5'-deoxy-5'-fluorouridine (5'-DFUR), medroxyprogesterone acetate (MPA) and cyclophosphamide (CPA)].

Author: TakatsukaY, KatohT, TsumuraI, KobayakawaK, KawaharaT

Breast cancer treatment
Diarrhea
Moon face

A patient with disseminated breast cancer refractory to previous therapies achieved partial response to a combination of 5'-DFUR, MPA, and CPA. The combination was well tolerated and provided a favorable quality of life.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

6.

[Doxifluridine, medroxyprogesterone acetate and cyclophosphamide (DMpC) combination therapy is effective against recurrent triple negative breast cancer--a case report].

Author: SakuraiTeruhisa, UmemuraTeiji, JintaEri, SuzumaTakaomi, YoshimuraGoro, ShimizuSayuri, SakuraiTakeo

Treat breast cancer

This report describes a postmenopausal breast cancer patient with triple negative disease who experienced recurrent nerve palsy due to lymph node metastases. Oral DMpC combination therapy resulted in a remarkable response with complete disappearance of the nerve palsy.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

7.

[Two cases of pulmonary metastasis of colorectal cancer successfully treated with oral 5'-DFUR].

Author: KatoM, SawaiK, NoguchiA, MinatoH, TakahashiT

Effective treatment
Side effects

Oral 5'-DFUR was effective in treating pulmonary metastasis of colorectal cancer in two patients.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

8.

[Combination therapy with Anastrozole and 5'-DFUR as a treatment for metastatic breast cancer].

Author: MiyoshiKazuya, OhtsukaShinya, InagakiMasaru, OhsakiToshihide, FuchimotoSadanori, YumuraMasahito, NakagawaTomio

Metastatic breast cancer treatment
Response rate increase
Survival prolongation

A combination therapy with Anastrozole and 5'-DFUR was studied in patients with metastatic breast cancer. The therapy was found to be effective with few side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

9.

[Intra-arterial chemotherapy of the liver].

Author: TuchmannA

Liver cancer treatment
Limited response
Regional side effects
Short survival

Hepatic artery infusion chemotherapy is a treatment for non-resectable liver metastases or tumors. While effective in some cases, its response rate is only 50%, with a mean survival time of one year or less. Further research is needed to improve response rates and reduce side effects.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

10.

[Multi-institutional trials of radiation and Furtulon combination therapy for malignant tumors].

Author: KamataR, SaitoT, YamashitaT, SekiguchiK, ShibuyaH, HoriuchiJ, EbataK, SanukiE, EndoM, SatoK

Tumor response
Diarrhea
Dysphagia
Impaired general condition
Leukocytopenia
Radiation dermatitis

Combination therapy of radiation and furtulon, a derivative of fluoropyrimidine, was effective and safe in treating malignant tumors. Out of 30 evaluable cases, 77% showed a complete or partial response.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : Japanese

11.

[A case of multiple pulmonary metastases from duodenal cancer showing partial response using 5'-DFUR and a small dose of MMC].

Author: HashimotoT, ArakiH, YoshiokaT, YasuiK, KodamaM

Partial response to metastases
Anorexia
Diarrhea

A combination of 5'-DFUR and a small dose of MMC showed partial response to multiple pulmonary metastases from duodenal cancer. The side effects of 5'-DFUR were diarrhea and anorexia.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

12.

[A case of advanced breast cancer with multiple lung metastases responding well to postoperative combined administration of doxifluridine (5'-DFUR) and tamoxifen].

Author: TohmaH, NoshiroH, HachiyaY, AkashiY, MiyoshiA

Tumor regression

This case report describes a 72-year-old female with right breast cancer and lung metastases who achieved complete tumor disappearance after treatment with 5'-DFUR and tamoxifen.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

13.

[A case of advanced breast cancer responding to low-dose 5'-DFUR].

Author: KohJ, MurayamaY, SanoM, KataiH, MaedaK, SakaiS, YamamotoO, HashimotoM, HosodaY

Tumor regression
Gastrointestinal side effects

This case report describes a patient with locally advanced breast cancer with multiple bone metastases who achieved complete remission after treatment with 5'-DFUR. The primary tumor and metastatic lymph nodes regressed, and bone metastasis was reduced.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

14.

[A case of colon cancer with multiple liver metastases and lymph nodes metastases successfully treated by 5'-deoxy-5-fluorouridine].

Author: HotokezakaMasayuki, IshimitsuToshiyuki, MatsumotoShinji, NakamuraKenjiro, TakedaShigeaki

Colon cancer treatment

This case report describes a 79-year-old man with ascending colon cancer who achieved remission after receiving oral 5'-deoxy-5-fluorouridine (5'-DFUR) treatment.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

16.

[Combination therapy of high dose 5'-DFUR+MMC for advanced or recurrent gastric cancer. 5'-DFUR Joint Research Group in the Osaka District for Gastric Cancer].

Author: NakataE, OkajimaK, IshidaY, MunetomoY, GotohK, ToyoharaM, MiyazakiH, MatsunagaS, MaeuraY, FujimuraT

Gastric cancer treatment
Diarrhea

This study investigated the efficacy of high-dose 5'-DFUR+MMC in treating advanced or recurrent gastric cancer. The overall response rate was 29.4%, with a median survival period of 249 days.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Language : Japanese

17.

Alternating hepatic intra-arterial floxuridine and fluorouracil: a less toxic regimen for treatment of liver metastases from colorectal cancer.

Author: StaggR J, VenookA P, ChaseJ L, LewisB J, WarrenR S, RohM, MulvihillS J, GrobmanB J, RaynerA A, HohnD C

Colorectal cancer treatment
Biliary toxicity
Systemic side effects

Alternating hepatic intra-arterial infusion of floxuridine and fluorouracil was found to be an effective and well-tolerated treatment for colorectal cancer metastasized to the liver. In a phase II trial of 68 patients, the regimen achieved a major response rate of 50% and a median survival of 22.4 months, with no patients having treatment terminated due to drug toxicity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

18.

[Clinical application of FdUrd to meningeal dissemination of malignant tumors].

Author: NakagawaH, YamadaM, MaedaN, IwatsukiK, TsuzukiT, HirayamaA, YamamotoH, IkenakaK

Safe and effective for meningeal tumors
Headache
Nausea

Intrathecal FdUrd was found to be safe and effective for the treatment of meningeal dissemination of malignant tumors.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

19.

Chronomodulated 5-day infusion of floxuridine and L-folinic acid in patients with advanced malignancies: a feasibility and tolerability study.

Author: GarufiC, LéviF, GiuntaS, AschelterA, PaceR, NisticòC, TerzoliE

Cancer treatment
Diarrhea
Mucositis

A 5-day chronotherapy schedule of floxuridine combined with leucovorin was found to be safe and effective in treating advanced cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

[Evaluation of combination therapy of high-dose toremifene and oral chemotherapy].

Author: MurakamiShigeki, YamamotoYasuhisa

Breast cancer recurrence treatment
Headache
Nausea
Stomatitis

High-dose toremifene therapy is useful for the recurrence of receptor-positive breast cancer. Combination therapy of high-dose toremifene and oral chemotherapy is also useful.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

21.

[Combination therapy with 5'DFUR and MPA as a second line treatment for advanced/recurrent breast cancer].

Author: KoyamaH, NishizawaY, NoguchiS, YamamotoH, MiyauchiK, InajiH, ImaokaS, IwanagaT

Cancer response
Improved performance
Pain relief
Diarrhea
Dose reduction
Leg edema
Obesity
Venous thrombosis

Combination therapy with MPA and 5'DFUR is effective in treating recurrent breast cancer, with a 42% overall response rate. It is particularly effective for bone and visceral lesions. Side effects include obesity, edema, and diarrhea.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

22.

Effects of oral 5-fluorouracil drugs on hepatic fat content in patients with colon cancer.

Author: MiyakeKanae, HayakawaKatsumi, NishinoMizuki, MorimotoTaisuke, MukaiharaSumio

Hepatic steatosis

This study investigates the effects of oral 5-fluorouracil (5-FU) therapy on hepatic fat content in patients. It examines the differences in effects across three subgroups of 5-FU drugs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

24.

Creation and characterization of 5-fluorodeoxyuridine-resistant Arg50 loop mutants of human thymidylate synthase.

Author: LandisD M, HeindelC C, LoebL A

cancer treatment

Mutants of human thymidylate synthase, created through random sequence mutagenesis, were identified that exhibit resistance to 5-FdUR, a potent inhibitor of thymidylate synthase. These mutant enzymes could potentially be used to protect bone marrow cells from the cytotoxic effects of 5-FU chemotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

25.

[Evaluation of weekly paclitaxel and doxifluridine (5'-DFUR) combination therapy in patients with advanced or recurrent breast cancer].

Author: OkamotoYasushi, TominagaTakeshi, OkuyamaNobuo, SawadaTerumasa, KouYoumo

Breast cancer treatment
Leukopenia
Malaise
Nausea
Peripheral neuropathy

This pilot study evaluated the feasibility and efficacy of weekly paclitaxel and 5'-DFUR combination therapy in patients with advanced or recurrent breast cancer. The regimen was feasible and effective, with a response rate of 46.2%.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

26.

Circadian chemotherapy for gynecological and genitourinary cancers.

Author: KobayashiMinoru, WoodPatricia A, HrusheskyWilliam J M

Treat cancer
Toxicity

Circadian timing of cancer therapies can improve toxicity profiles, tumor control, and survival. Optimally timed chemotherapy with doxorubicin, pirarubicin, cisplatin, and fluorodeoxyuridine (FUDR) has shown improved efficacy and reduced toxicity in various cancers, including ovarian, endometrial, bladder, and renal cell carcinoma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

27.

[Intra-arterial infusion chemotherapy for liver metastases from breast cancer].

Author: MasudaN, YayoiE, FurukawaJ, MaruhashiS, TokunagaM, TakiguchiS, MatsuiS, YanoH, TateishiH, KinutaM, MaruyamaH, OoiH, OkamuraJ

Breast cancer treatment
Liver metastasis control
Alopecia
Bone marrow depression
Gastrointestinal disturbance

Hepatic arterial infusion therapy with epi-adriamycin and 5-fluorouracil, followed by systemic chemo-endocrine therapy with me droxyprogesterone acetate, was effective in controlling liver metastases of breast cancer in 41.7% of patients. The survival rate at one year was 46.8%.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

29.

[Combination therapy of high dose doxifluridine (5'-DFUR)+mitomycin C (MMC) for advanced or recurrent colorectal cancer. Joint Research Group in the Osaka Area for Combination Therapy of 5'-DFUR with Other Drugs].

Author: KikkawaN, TaguchiT, SakaiK, IrieK, TerasawaT, ShimoyamaT, IwanagaT, FukudaI, OkumuraS, YasutakeK

Cancer treatment
Tumor response
Gastrointestinal side effects

This study found that high-dose 5'-DFUR+MMC chemotherapy was effective in treating advanced and recurrent colorectal cancers, especially those with pulmonary metastases. The most common side effects were gastrointestinal.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

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