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Oral treatment of murine cytomegalovirus infections with ether lipid esters of cidofovir.

Author: BeadleJames R, CollinsDeborah J, HostetlerKarl Y, KernEarl R, QuenelleDebra C, WanW Brad

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study evaluated the efficacy of oral ether lipid ester prodrugs of cidofovir (CDV) against murine cytomegalovirus (MCMV) infection in mice. The results showed that oral HDP-CDV or ODE-CDV was as effective as parenteral CDV for treating MCMV infection, suggesting potential for further evaluation in humans.
Paper Details　
Original Abstract of the Article :
To improve the oral bioavailability of cidofovir (CDV), a series of ether lipid ester prodrugs were synthesized and evaluated for activity against murine cytomegalovirus (MCMV) infection. Four of these analogs, hexadecyloxypropyl (HDP)-CDV, octadecyloxyethyl (ODE)-CDV, oleyloxyethyl (OLE)-CDV, and o...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC514741/

データ提供：米国国立医学図書館（NLM）

Fighting Viral Infections: Making Cidofovir More Bioavailable

The quest for effective antiviral therapies is a continuous journey, like a camel trekking through a vast desert, seeking a safe haven from the scorching sun. This research focuses on cidofovir (CDV), a potent antiviral agent used against cytomegalovirus (CMV), a virus that can cause serious infections. The researchers sought to enhance CDV's bioavailability, meaning increasing its ability to reach the target tissues and fight the infection. Their aim: to make CDV a more effective weapon in the battle against CMV.

The researchers synthesized a series of ether lipid ester prodrugs of CDV, like carefully crafting different types of oases, each designed to deliver a unique blend of water and nutrients for the thirsty traveler. They found that these prodrugs had greater activity against CMV in vitro, meaning they were more effective in killing the virus in a laboratory setting. These prodrugs then underwent rigorous testing in mice, simulating the real-world conditions of infection. The results were promising, demonstrating that oral administration of these prodrugs was as effective as intraperitoneal administration of CDV.

A New Frontier in Antiviral Treatment: Unlocking the Potential of Oral Delivery

The study's findings pave the way for a new era in antiviral treatment, one that focuses on oral delivery of effective antiviral agents. This could revolutionize the treatment of CMV infections, making it more convenient and accessible for patients. Think of this advancement as discovering a new oasis with a spring of fresh water, easily accessible to all travelers.

Dr. Camel's Conclusion

This research holds immense promise for the treatment of CMV infections. The successful development of oral prodrugs of CDV could transform the way we approach this viral threat. Further clinical trials are needed to confirm the safety and efficacy of these prodrugs in humans. However, this research serves as a testament to the power of scientific innovation and its potential to improve the lives of patients.

Date :
  1. Date Completed 2004-10-18
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

15328119

DOI: Digital Object Identifier

PMC514741

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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