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Comparison of the effects of dietary plant sterol and stanol esters on lipid metabolism.

Author: BrynesA, MandenoR, O'NeillF H, RendellN, SeedM, TaylorG, ThompsonG R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Plant stanols are more effective than plant sterols in lowering cholesterol, as plant sterols suppress bile acid synthesis and diminish their efficacy.
Paper Details　
Original Abstract of the Article :
BACKGROUND AND AIM: To compare the cholesterol-lowering efficacy and other metabolic effects of plant sterol and stanol esters, both of which are commonly used in the dietary management of hypercholesterolaemia. METHODS AND RESULTS: The cholesterol-lowering efficacy of equivalent intakes of sterol ...See full text at original site
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引用元：
https://doi.org/10.1016/s0939-4753(04)80033-4

データ提供：米国国立医学図書館（NLM）

Plant Sterols and Stanols: A Cholesterol-Lowering Duel

Cholesterol is a crucial component of our bodies, but high levels can pose health risks. This research investigates the cholesterol-lowering effects of plant sterols and stanols, both of which are commonly used to manage hypercholesterolemia. The researchers compared the effects of equivalent intakes of these compounds on lipid metabolism in both healthy individuals and patients with familial hypercholesterolemia.

Imagine a desert oasis with two distinct types of palm trees, each offering a unique blend of nutrients. Plant sterols and stanols, like these trees, offer different mechanisms for lowering cholesterol levels. The researchers found that both sterols and stanols effectively reduced cholesterol levels, but sterols showed a diminished effect over time. This reduction in efficacy was linked to an increase in sterol absorption and a decrease in bile acid synthesis, suggesting a potential trade-off in the body's response to these compounds.

A Complex Landscape of Cholesterol Regulation

This study highlights the complex interplay of various factors in cholesterol regulation. It suggests that plant stanols may be a more consistent and effective option for lowering cholesterol levels due to their ability to reduce sterol absorption and maintain their efficacy over time.

Making Informed Choices

This research underscores the importance of making informed choices about dietary supplements, particularly those aimed at managing cholesterol levels. Consulting with a healthcare professional is essential for personalized guidance based on individual health needs and medical history.

Dr.Camel's Conclusion

The quest for optimal cholesterol management is a journey through a complex and dynamic landscape. This research sheds light on the subtle differences between plant sterols and stanols, offering valuable insights into their respective effects on cholesterol levels. As with all dietary supplements, it's essential to consult with a trusted health professional for personalized advice.

Date :
  1. Date Completed 2004-11-06
  2. Date Revised 2019-11-08
Further Info :

Pubmed ID

15330272

DOI: Digital Object Identifier

10.1016/s0939-4753(04)80033-4

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Languages

English

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