Delayed administration may improve entacapone effects in parkinsonian patients non-responding to the drug.

Author: BassiA, BrusaL, FedeleE, LunardiG, PasqualettiP, PeppeA, PierantozziM, StanzioneP, StefaniA

Paper Details 
Original Abstract of the Article :
Entacapone is a COMT inhibitor used in Parkinson's disease (PD) patients, as an adjunctive therapy to L-dopa in order to prolong its bioavailability and thus its clinical effect. However, previous studies reported entacapone-induced L-dopa to have lower C(max) and delayed t(max) values, coupled with...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/15379738

データ提供:米国国立医学図書館(NLM)

Entacapone: Timing is Key for Parkinson's Disease

Hello there, fellow researchers! Dr. Camel here, ready to delve into the complexities of Parkinson's disease and the role of medication timing. This study, like a careful analysis of a desert caravan's route, investigates the effectiveness of entacapone, a medication used to manage Parkinson's symptoms, when administered at different times.

The researchers, like astute desert explorers, noticed that entacapone, a medication used to enhance the effects of another Parkinson's drug called L-dopa, sometimes caused a delay in the onset of L-dopa's benefits. They wondered if delaying the administration of entacapone might improve its effectiveness. Their findings, like a shift in the caravan's route, suggested that delaying entacapone administration in some individuals could indeed enhance the overall benefits of L-dopa, extending the period of symptom relief.

Timing is Everything: A Desert Oasis of Improved Treatment

This study sheds light on the importance of medication timing in managing Parkinson's disease. It's like adjusting the timing of a desert oasis's water flow, ensuring that it reaches the thirsty plants at the most beneficial time. The findings suggest that delaying entacapone administration, like a slight shift in the caravan's route, can optimize its effectiveness and enhance the overall benefits of L-dopa therapy.

Managing Parkinson's: A Journey Through a Desert of Symptoms

This research underscores the importance of individualized care in managing Parkinson's disease. It's like customizing a desert journey, choosing the best route and timing for each traveler. Consulting with a healthcare professional to determine the optimal medication schedule is crucial for maximizing the benefits of treatment and minimizing side effects.

Dr.Camel's Conclusion

This study emphasizes the importance of medication timing in managing Parkinson's disease. It's like discovering a hidden spring in a desert, providing a new and more effective way to manage a complex condition. The findings encourage us to consider individual needs and adjust treatment strategies accordingly, ultimately aiming to improve the quality of life for those living with Parkinson's disease.

Date :
  1. Date Completed 2004-11-19
  2. Date Revised 2015-11-13
Further Info :

Pubmed ID

15379738

DOI: Digital Object Identifier

ENE860

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Languages

English

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