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The effects of acetazolamide on the ventilatory response to high altitude hypoxia.
Author: BurkiN K, HameedM A, KhanS A
Original Abstract of the Article :
Acetazolamide treatment ameliorates the symptoms of AMS; however, the mechanism by which this occurs is unclear. To examine the effects of acetazolamide on oxygenation, CO2 responsiveness and ventilatory pattern during acute exposure to HA, we studied two groups of subjects at SL and following rapid...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1378/chest.101.3.736
データ提供:米国国立医学図書館(NLM)
Acetazolamide and the Ventilatory Response to High Altitude Hypoxia
This study examines the effects of acetazolamide, a medication used to treat altitude sickness, on the ventilatory response to high altitude hypoxia. The authors investigate whether acetazolamide improves oxygenation and CO2 responsiveness during exposure to high altitude, and if it influences the pattern of breathing.
Acetazolamide and the Thin Air of High Altitude
The study found that acetazolamide treatment did not significantly alter the ventilatory pattern at high altitude. However, it was associated with better oxygenation and a higher level of ventilation compared to placebo. This suggests that the beneficial effects of acetazolamide in altitude sickness are likely due to its ability to increase ventilation and improve oxygenation, rather than affecting CO2 chemosensitivity.
Climbing the Mountain of Knowledge
This research provides valuable insights into the physiological mechanisms underlying altitude sickness and the effectiveness of acetazolamide in treating this condition. It's like climbing a challenging mountain, where understanding the effects of altitude on the body is crucial for success. This study highlights the importance of personalized approaches to managing altitude sickness, considering individual factors and potential benefits of different treatments.
Dr.Camel's Conclusion
This study provides valuable insights into the mechanisms by which acetazolamide improves oxygenation and ventilation at high altitude. It suggests that acetazolamide may be a useful treatment for altitude sickness, potentially by increasing ventilation and improving oxygen transport to the tissues. Further research is needed to understand the full range of effects of acetazolamide and to develop more effective strategies for managing altitude sickness.
Date :
- Date Completed 1992-04-08
- Date Revised 2019-05-14
Further Info :
Related Literature
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