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Dysphoric mania.

Author: ClothierJ, FreemanT, SwannA C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Lithium is the primary treatment for bipolar disorder, but patients with syndromal variations, such as those experiencing mixed states or dysphoria, have a poorer response. A study comparing lithium and valproate for mania control found that pretreatment depression scores were higher in patients responding to valproate. Further research is needed on mixed or dysphoric manic states and predictors of response to treatment.
Paper Details　
Original Abstract of the Article :
Lithium remains the mainstay of therapy for most patients with bipolar disorder. Patients with syndromal variations of bipolar disorder, such as those experiencing mixed states or dysphoria have generally had a rather poor therapeutic response to lithium. Our group conducted a double-blind, parallel...See full text at original site
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引用元：
https://doi.org/10.1097/00004714-199202001-00003

データ提供：米国国立医学図書館（NLM）

Dysphoric Mania: A Challenging Aspect of Bipolar Disorder

The world of mental health is like a vast desert, with many hidden oases of different conditions. One such oasis is Bipolar Disorder, a condition characterized by extreme mood swings. This research, published in the Journal of Clinical Psychiatry, focuses on a specific aspect of Bipolar Disorder: dysphoric mania. The authors investigate the effectiveness of lithium and valproate in managing this complex form of mania, which is often marked by sadness, anxiety, and agitation.

Understanding the Nuances of Bipolar Disorder

This study sheds light on the complexities of bipolar disorder. The researchers investigated whether certain characteristics of the illness, such as pretreatment depression scores, might predict the effectiveness of different medications. Their findings suggest that valproate might be a better option for patients with higher pretreatment depression scores, while lithium and valproate have similar efficacy in managing mixed states characterized by both mania and depression.

The Importance of Personalized Treatment

This research emphasizes the importance of tailored treatment approaches for patients with bipolar disorder. Imagine a caravan traveling through the desert, where different camels require different supplies to thrive. The same goes for patients with bipolar disorder, as each individual may respond differently to medications. The study's findings provide valuable information for clinicians to customize treatment strategies, leading to better outcomes for patients.

Dr. Camel's Conclusion

This study highlights the complexities of treating dysphoric mania, a challenging aspect of bipolar disorder. The findings suggest that different medications might be more effective for different patients. Think of a camel caravan in a desert, where some camels might thrive on one type of vegetation while others prefer another. Tailored treatment strategies are crucial for improving the lives of those living with bipolar disorder.

Date :
  1. Date Completed 1992-04-06
  2. Date Revised 2019-09-07
Further Info :

Pubmed ID

1541712

DOI: Digital Object Identifier

10.1097/00004714-199202001-00003

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・Effective treatment of bipolar disorder
SNS
PICO Info
in preparation
Languages

English

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