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Effects of neonatal exposure to diethylstilbestrol, tamoxifen, and toremifene on the BALB/c mouse mammary gland.

Author: Asai-SatoMikiko, ColynNira, GinsburgErika, HoveyRussell C, Terry-KoromaBarbara, VonderhaarBarbara K, WarriAnni

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Neonatal exposure to diethylstilbestrol (DES) and tamoxifen (TAM) can have long-lasting effects on mammary gland development and differentiation. DES stimulates mammary duct growth and precocious lactogenesis, while TAM can both stimulate and inhibit alveolar development.
Paper Details　
Original Abstract of the Article :
In this study, we compared the long-term effects of neonatal exposure to diethylstilbestrol (DES, 0.0125-50 microg), tamoxifen (TAM, 0.0125-50 microg), and toremifene (TOR, 53 microg) on mammary gland development and differentiation. Allometric growth of the mammary ducts was stimulated by neonatal ...See full text at original site
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引用元：
https://doi.org/10.1095/biolreprod.104.029769

データ提供：米国国立医学図書館（NLM）

The Lasting Impact of Neonatal Exposure to Endocrine Disruptors

This research explores the long-term effects of neonatal exposure to diethylstilbestrol (DES), tamoxifen (TAM), and toremifene (TOR) on mammary gland development in mice. The authors used a comparative approach to investigate the impact of these endocrine disruptors on mammary gland growth, differentiation, and subsequent hormonal responses.

Endocrine Disruption and Mammary Gland Development

The study revealed that neonatal exposure to DES and TAM had significant, long-lasting effects on mammary gland development in female BALB/c mice. DES exposure stimulated ductal growth, while TAM exposure impaired it. Both DES and TAM also influenced alveolar development, with high doses of DES leading to precocious lactogenesis. These findings highlight the sensitive nature of mammary gland development and the potential for endocrine disruptors to alter its course.

Implications for Human Health

This study provides valuable insights into the potential consequences of exposure to endocrine disruptors during early development. While further research is needed to fully understand the implications for human health, the study raises concerns about the potential impact of environmental exposures on mammary gland development and subsequent risk for breast cancer.

Dr.Camel's Conclusion

This study demonstrates the importance of understanding the intricate interplay between endocrine disruptors and developmental processes. Like a camel navigating the delicate balance of the desert ecosystem, we must be mindful of the potential impact of human activity on sensitive biological systems. Further research is needed to fully understand the implications of these findings for human health and to inform preventive measures.
Date :
  1. Date Completed 2005-05-24
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15470002

DOI: Digital Object Identifier

10.1095/biolreprod.104.029769

Related Literature

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・Effects of toremifene
SNS
PICO Info
in preparation
Languages

English

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