The assessment of genotoxic effects in lymphocyte cultures of infants treated with chloral hydrate.

Author: DoganHasan, IkbalMevlit, OrsRahmi, PirimIbrahim, TastekinAyhan

Paper Details 
Original Abstract of the Article :
Chloral hydrate is a sedative commonly used in pediatric medicine. It was evaluated for genotoxicity in cultured peripheral blood lymphocytes of infants who were given chloral hydrate for sedation. Sister chromatid exchange and micronucleus frequencies were determined before and after chloral hydrat...See full text at original site
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引用元:
https://doi.org/10.1016/j.mrgentox.2004.08.007

データ提供:米国国立医学図書館(NLM)

The Hidden Dangers of Sedation: Exploring the Genotoxic Potential of Chloral Hydrate in Infants

Imagine a desert landscape, where seemingly benign plants can harbor hidden toxins. This research explores the use of chloral hydrate, a sedative commonly used in pediatric medicine, examining its potential for causing genetic damage in infants. The study investigates the genotoxic effects of this medication, seeking to understand its potential impact on the delicate genetic makeup of young patients.

A Closer Look at the Sands: Investigating the Genotoxic Effects of Chloral Hydrate

The researchers conducted a study of infants who were given chloral hydrate for sedation, analyzing their blood samples before and after medication administration. The study found that after treatment with chloral hydrate, the frequency of sister chromatid exchange and micronuclei, both indicators of genetic damage, was significantly increased. These findings suggest that chloral hydrate may have a moderate genotoxic potential in infants, raising concerns about its long-term safety.

Balancing the Scales: Weighing the Risks and Benefits of Chloral Hydrate

This research serves as a cautionary tale, reminding us that even seemingly safe medications can have unintended consequences. It highlights the importance of careful consideration when prescribing medications to infants, weighing the potential benefits against the potential risks. Just as a desert traveler must carefully choose their route to avoid hidden dangers, so too must we approach the use of medications with a discerning eye.

Dr. Camel's Conclusion

This research underscores the importance of ongoing vigilance and careful consideration when using medications in children. It's a reminder that we must always strive to understand the full spectrum of potential effects, even for seemingly innocuous medications. Like a seasoned desert guide, we must be ever watchful for the unseen dangers that may lurk beneath the surface.

Date :
  1. Date Completed 2005-01-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15507380

DOI: Digital Object Identifier

10.1016/j.mrgentox.2004.08.007

Related Literature

SNS
PICO Info
in preparation
Languages

English

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