Paper Details

  1. Home
  2. Paper Details

Add-on therapy options in asthma not adequately controlled by inhaled corticosteroids: a comprehensive review.

Author: BarnesPeter J, KankaanrantaHannu, LahdensuoAarne, MoilanenEeva

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Inhaled corticosteroids (ICS) are effective for many people with persistent asthma, but some still have symptoms. Research shows that adding a long-acting beta2-agonist (LABA) to ICS is more effective than increasing the ICS dose alone. Increasing the ICS dose may provide a small improvement, while adding a leukotriene antagonist (LTRA) or theophylline seems similar to doubling the ICS dose. LABA may be better than LTRA for lung function, but they may be similar for preventing asthma attacks. More research is needed on LTRAs and theophylline as add-on treatments.
Paper Details　
Original Abstract of the Article :
Many patients with persistent asthma can be controlled with inhaled corticosteroids (ICS). However, a considerable proportion of patients remain symptomatic, despite the use of ICS. We present systematically evidence that supports the different treatment options. A literature search was made of Medl...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC528858/

データ提供：米国国立医学図書館（NLM）

Adding to the Arsenal of Asthma Treatment: A Search for the Right Approach

Asthma is a chronic respiratory disease that affects millions of people worldwide. While inhaled corticosteroids (ICS) are a mainstay of treatment, many patients continue to experience symptoms. This study reviewed the evidence for different add-on therapies that can be used to improve asthma control in patients who are not adequately controlled with ICS alone. The researchers systematically reviewed the literature to identify studies that compared different treatment options. Their findings provide valuable insights into the potential benefits and drawbacks of various add-on therapies.

Expanding the Arsenal of Asthma Treatment

The study found that adding a long-acting beta2-agonist (LABA) to ICS was more effective in improving asthma control than increasing the dose of ICS alone. Adding a leukotriene antagonist (LTRA) or theophylline appeared to be equivalent to doubling the dose of ICS. However, the researchers noted that more and longer studies are needed to fully clarify the roles of LTRAs and theophylline as add-on therapies.

Navigating the Desert of Asthma Treatment

The study's findings provide valuable information for patients with asthma and their healthcare providers. The choice of add-on therapy should be made on an individual basis, taking into account the patient's specific needs and the potential benefits and risks of different treatment options.

Dr.Camel's Conclusion

Asthma treatment can be a challenging journey, like navigating a vast desert landscape. This study provides valuable insights into the benefits and drawbacks of different add-on therapies, helping patients and their doctors find the most effective path to improved asthma control. As we continue to explore the desert of asthma treatment, we must remain open to new approaches and strive to find the most effective and personalized therapies.

Date :
  1. Date Completed 2006-03-14
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

15509300

DOI: Digital Object Identifier

PMC528858

Related Literature

Article Analysis
・Effective treatment of asthma
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.