Effective treatment of asthma: A Synthesis of Findings from 124 Studies

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Original Abstract of the Article

Main Research Findings

Asthma is characterized by chronic airway inflammation and recurrent exacerbations with wheezing, chest tightness, and coughing. 88

The goal of asthma treatment is to control asthma, especially to prevent exacerbations. 35

Asthma exacerbations can be triggered by viral respiratory infections, poor adherence to medication, changes in weather, or exposure to allergens or irritants. 117

During severe exacerbations, patients may need to go to a medical center or hospital emergency department for treatment with systemic corticosteroids, which can be administered intravenously or orally. 106

Asthma is one of the most common chronic conditions in the United States, yet despite the existence of national guidelines, nearly three-fourths of patients with asthma do not have adequate control and clinical adherence to guidelines is low. 49

Asthma is a chronic disorder, characterized by airway hyperresponsiveness (AHR), airway inflammation, and airway remodeling. 38

Treatment Summary

Asthma treatment often involves inhaled steroids and bronchodilators. 88

Combination therapies using inhaled steroids and β2-agonists (long- and short-acting) are available in single inhalers for once or twice daily use. For symptom relief as needed, patients may use a separate inhaler. 88

Inhaled corticosteroids are the cornerstone of persistent asthma treatment. 38

Increasing the dosage of inhaled corticosteroids is recommended as a first step in treating asthma exacerbations. 102

Systemic corticosteroid therapy is central to the management of acute asthma. Inhaled corticosteroids (ICS) may also be beneficial in this setting. 15

For adults with asthma whose symptoms are not well controlled on inhaled corticosteroids (ICS), long-acting β2-agonists (LABA) are the preferred add-on treatment. 97

At the first sign of an exacerbation, a short-term increase in the dose of inhaled corticosteroids (ICS) may be advocated to reduce the severity of the attack and to prevent the need for oral steroids or hospital admission. 122

Asthma treatment should consider patient impairment, risk, quality of life, and functional capacity. 57

Benefits and Risks

Benefit Summary

Inhaled corticosteroids are effective in controlling asthma and preventing exacerbations. 38

Combination therapies using inhaled corticosteroids and β2-agonists are effective in controlling asthma symptoms and preventing exacerbations. 88

Long-acting β2-agonists are recommended as add-on therapy when asthma control is insufficient with inhaled corticosteroids. 97

Risk Summary

Side effects of inhaled corticosteroids may include hoarseness and oral candidiasis. 38

Long-acting β2-agonists may increase the risk of asthma exacerbations. 97

Comparison Across Studies

Commonalities

All studies showed that inhaled corticosteroids are effective in treating asthma. 38 , 29 , 81 , 82 , 102 , 122

Many studies demonstrated that combinations of inhaled corticosteroids and β2-agonists are beneficial for asthma control. 88 , 61 , 60 , 64

Differences

Studies may vary in the medications used, dosages, and treatment durations. 35 , 88 , 117 , 106 , 49 , 38 , 77 , 101 , 124 , 36 , 86 , 102 , 27 , 58 , 66 , 105 , 70 , 72 , 25 , 33 , 71 , 57 , 26 , 21 , 16 , 4 , 97 , 122 , 96 , 82 , 29 , 108 , 81 , 116 , 15 , 91 , 61 , 60 , 64 , 99

Consistency and Contradictions in Results

There are both consistencies and contradictions in the research findings. 38 , 29 , 81 , 82 , 102 , 122 , 88 , 61 , 60 , 64

There is consistency in the finding that inhaled corticosteroids are effective in treating asthma, but the effectiveness of combinations of inhaled corticosteroids and β2-agonists may vary across studies. 38 , 29 , 81 , 82 , 102 , 122 , 88 , 61 , 60 , 64

Considerations for Real-World Application

Choosing the right medication for asthma treatment is crucial based on each patient's condition and symptoms. 38 , 29 , 81 , 82 , 102 , 122 , 88 , 61 , 60 , 64

It's important to follow instructions for medication usage and dosage, and to receive regular medical checkups. 38 , 29 , 81 , 82 , 102 , 122 , 88 , 61 , 60 , 64

Limitations of Current Research

Research on asthma treatment is still ongoing and needs further development. 38 , 29 , 81 , 82 , 102 , 122 , 88 , 61 , 60 , 64

In particular, studies evaluating long-term effects and safety are lacking. 38 , 29 , 81 , 82 , 102 , 122 , 88 , 61 , 60 , 64

Future Research Directions

Future research on asthma treatment should include studies evaluating long-term effects and safety, combination therapies with different medications, and personalized treatment approaches based on individual patient needs. 38 , 29 , 81 , 82 , 102 , 122 , 88 , 61 , 60 , 64

Conclusion

Asthma is a chronic condition, but proper treatment can help control symptoms and prevent exacerbations. 38 , 29 , 81 , 82 , 102 , 122 , 88 , 61 , 60 , 64

It is important to work with your doctor to determine the best treatment for your individual needs. 38 , 29 , 81 , 82 , 102 , 122 , 88 , 61 , 60 , 64

Treatment List

Inhaled corticosteroids, long-acting β2-agonists, long-acting muscarinic antagonists, systemic corticosteroids, oral steroids, leukotriene receptor antagonists, β2-agonists, bronchodilators, antihistamines, anti-inflammatory drugs.

Keywords
Benefit Keywords
Asthma treatment
1
Improved asthma treatment
2
Improved asthma management
3
Improved asthma management
4
Pulmonary function improvement
Symptom control
5
Reduced asthma hospitalization rates
6
Faster recovery
Reduced bronchoconstriction
8
Improved asthma control
Increased days with no symptoms
Increased nights with no awakenings
Reduced albuterol use
Reduced symptoms
9
Improved lung function
Reduced hospital admissions
10
Improved lung function
Reduced asthma symptoms
11
Asthma control
Improved lung function
12
Asthma treatment
Improved lung function
Reduced rescue medication use
14
Asthma treatment
Reduced admissions
15
Effective treatment of asthma
16
Nebuliser efficacy
17
Alternative therapy
Steroid sparing
18
Alternative therapy
Steroid sparing
19
Asthma treatment
20
Prevention of asthma
21
Improved asthma control
Improved patient satisfaction
22
Asthma treatment
23
Asthma treatment
24
Improved asthma outcomes
25
Improved peak flow
Reduced hospital admissions
26
Asthma treatment effective
27
Asthma treatment
28
Decreased oral corticosteroid use
Improved pulmonary function
29
Asthma treatment
30
Improved lung function
Reduced hospital admission
31
Asthma control
Lung function
32
Improved asthma outcomes
33
Asthma treatment
34
Asthma control
35
Asthma treatment
36
Asthma treatment
37
Asthma treatment
38
Improved asthma management
Increased compliance
39
Improve asthma
40
Improved lung function
Reduced rescue medication use
41
Asthma treatment
42
Asthma treatment
43
No effect on linear growth
Reduced beta-agonist use
44
Reduced asthma risk
45
Increased FEV1
46
Asthma control
47
Asthma treatment
Cost-effective
48
Improved asthma treatment
49
Reduced asthma exacerbations
50
Asthma control
51
Reduced hospitalizations
Reduced relapse
52
Asthma management
53
Improved asthma treatment
54
Improved asthma control
Reduced exacerbations
Well tolerated
55
Reduced asthma exacerbations
56
Asthma treatment
Improved well-being
57
Asthma treatment
58
Asthma treatment
Episodic asthma treatment
59
Improved asthma control
60
Asthma treatment
61
Improved asthma symptoms
Improved lung function
62
Asthma treatment
63
Asthma treatment
65
Asthma treatment
66
Asthma control
Improved lung function
Improved quality of life
67
Asthma symptom reduction
68
Lung function improvement
69
Asthma treatment
70
Asthma treatment
71
Asthma treatment
72
Asthma treatment
73
Treatment of asthma
74
Assessment of asthma severity
75
Treatment of childhood asthma
76
Treatment of acute asthma
77
Improved lung function
78
Treatment of severe asthma
79
Reduced hospital admissions
80
Asthma control
Improved lung function
81
Improved lung function
82
Asthma exacerbation reduction
Hospital admission reduction
ICS dosage reduction
Oral corticosteroid reduction
83
Asthma treatment
84
Inhaled beta(2)-agonists
85
Asthma treatment
86
Allergic asthma treatment
87
Asthma treatment
88
acute asthma treatment
89
Asthma exacerbation reduction
90
Improved spirometry
Reduced asthma exacerbations
91
Asthma treatment
92
Improved QoL
Improved lung function
Reduced exacerbations
93
Improved asthma control
94
Asthma treatment
95
Asthma treatment
96
Asthma treatment
97
Asthma control improvement
98
Asthma treatment
99
Asthma treatment
100
Effective asthma treatment
101
Asthma treatment
102
Improved asthma symptom control
Improved lung function
Reduced asthma exacerbations
103
Asthma control
104
Asthma treatment
105
Asthma treatment
106
Asthma treatment
107
Asthma steroid response
108
Improved quality of life
Reduced medication use
109
Asthma treatment
Eosinophilic endotype
110
Acute asthma treatment
Systemic corticosteroids
111
Asthma treatment
Exacerbation management
112
Asthma treatment
Educational session
113
Asthma exacerbations treatment
Corticosteroids
114
Asthma improvement
Lung function improvement
115
Asthma treatment
116
Asthma treatment
117
Asthma treatment
118
Improved asthma control
Improved lung function
Improved quality of life
Reduced inflammation
119
Asthma exacerbation management
120
SMART and inhaled corticosteroid-long-acting β2-agonist for asthma
121
Asthma treatment
122
Asthma treatment
123
Asthma control
124
Risk Keywords
Beta 2 agonist side effects
1
Limited evidence
10
Increased withdrawal risk
11
Insufficient evidence
15
Corticosteroid-induced side effects
16
Insufficient evidence
17
Steroid side effects
18
Steroid side effects
19
Unclear long-term effects
21
Contribution of components unclear
25
Less effective than systemic corticosteroids
No significant change in pulmonary function
26
Pharyngitis
Respiratory infection
Sinusitis
29
Contribution of components unclear
33
Bronchial asthma
39
Bone marker imbalance
Decreased growth rate
44
Asthma
45
Exacerbation frequency
47
Asthma
49
Increased corticosteroid use
50
No difference in side effects
52
Asthma
54
Headache
55
None specified
56
Exacerbations
Serious adverse events
67
Dry mouth
69
Allergic comorbidities
73
Growth suppression
81
Growth suppression
82
Adverse events
Study withdrawal
83
Acute asthma
85
Serious adverse events
90
Insufficient evidence for clinical outcomes
91
Growth effects
92
Corticosteroid toxicity
101
Allergic reactions
Anaphylaxis
109
Limited evidence
119
Symptom/biomarker dissociation
123
Literature analysis of 124 papers
Positive Content
118
Neutral Content
6
Negative Content
0
Article Type
55
36
65
58
124
1.

Risks versus benefits of inhaled beta 2-agonists in the management of asthma.

Author: LipworthB J

Asthma treatment
Beta 2 agonist side effects

Asthma treatment aims to suppress inflammation with inhaled corticosteroids and relieve symptoms with bronchodilators. Lower doses of inhaled beta 2-agonists effectively dilate airways without systemic side effects, while higher doses may improve airway response for patients with severe obstruction but also cause systemic side effects. Regular use of inhaled beta 2-agonists may lead to increased bronchial hyperreactivity and require additional anti-inflammatory therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

Therapeutic regimes for acute bronchial asthma.

Author: AnantharamanV

Improved asthma treatment

A study of 71 patients with acute asthma compared the effectiveness of three common treatments: subcutaneous adrenaline, nebulized salbutamol, and intravenous aminophylline. All treatments improved peak flow rate and patient-reported symptom scores, with the greatest improvements seen in the salbutamol and adrenaline groups. Salbutamol also significantly improved respiratory rate. The study concluded that while the results were not conclusive about which drug was superior, salbutamol and adrenaline are preferred to aminophylline for initial treatment of acute asthma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

The asthma specialist and patient education.

Author: DonaghyD

Improved asthma management

Although effective treatments exist, asthma-related illnesses and deaths are increasing. Standard patient education in respiratory clinics is not enough. A formal asthma education program delivered by a specialist improved patients' understanding of asthma and their ability to use their inhalers correctly.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Eight key questions to ask when your patient with asthma doesn't get better.

Author: BerlowB A

Improved asthma management

While asthma treatment guidelines are generally effective, some patients may not improve despite following them. This review highlights eight key questions to consider when a patient's asthma management plan is not working: 1) environmental factors, 2) workplace factors, 3) patient adherence, 4) lack of education, 5) patient perception of symptoms, 6) medication administration technique, 7) incorrect treatment, and 8) underlying conditions other than asthma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Inhaled salmeterol and fluticasone: a study comparing monotherapy and combination therapy in asthma.

Author: PearlmanD S, StrickerW, WeinsteinS, GrossG, ChervinskyP, WoodringA, PrillamanB, ShahT

Pulmonary function improvement
Symptom control

Initiation of maintenance therapy with salmeterol and fluticasone propionate in patients with asthma treated with short-acting beta2-agonists alone provides greater improvements in pulmonary function and symptom control than initiation of maintenance therapy with fluticasone propionate alone. In a randomized study of 136 patients with asthma, patients treated with salmeterol combined with fluticasone propionate had improvements over baseline in FEV at endpoint that were at least twice as great as improvements in patients treated with salmeterol or fluticasone propionate alone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Oral versus intravenous corticosteroids in children hospitalized with asthma.

Author: BeckerJ M, AroraA, ScarfoneR J, SpectorN D, Fontana-PennM E, GracelyE, JoffeM D, GoldsmithD P, MalatackJ J

Reduced asthma hospitalization rates

Studies have shown that corticosteroids combined with beta-agonists reduce hospitalization rates for children and adults experiencing asthma attacks. Oral corticosteroids have also been shown to be effective for treating asthma in outpatients. However, there is a lack of similar evidence for the effectiveness of corticosteroids in hospitalized asthma patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Holding chambers versus nebulisers for beta-agonist treatment of acute asthma.

Author: Cates CJ, RoweB H

While nebulizers are commonly used to deliver inhaled medications for asthma attacks, some argue that inhalers with a spacer can be just as effective. Nebulizers are more expensive, require electricity, and need regular maintenance, suggesting that inhalers with spacers may be a more practical option in non-hospital settings.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

8.

Nedocromil sodium for preventing exercise-induced bronchoconstriction.

Author: SpoonerC H, SaundersL D, RoweB H

Faster recovery
Reduced bronchoconstriction

Nedocromil sodium used before exercise appears to reduce the severity and duration of exercise-induced bronchoconstriction. This effect appears to be more pronounced in people with severe exercise-induced bronchoconstriction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

Salmeterol and fluticasone propionate combined in a new powder inhalation device for the treatment of asthma: a randomized, double-blind, placebo-controlled trial.

Author: KavuruM, MelamedJ, GrossG, LaforceC, HouseK, PrillamanB, BaitingerL, WoodringA, ShahT

Improved asthma control
Increased days with no symptoms
Increased nights with no awakenings
Reduced albuterol use
Reduced symptoms

Salmeterol and fluticasone combined in a dry powder inhaler offer significant clinical advantages over salmeterol or fluticasone alone. The combination improved lung function, reduced symptoms, and decreased albuterol use.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Early use of inhaled corticosteroids in the emergency department treatment of acute asthma.

Author: EdmondsM L, CamargoC A, PollackC V, RoweB H

Improved lung function
Reduced hospital admissions
Limited evidence

Inhaled steroids reduced admission rates in patients with acute asthma who were not receiving concomitant systemic steroids. In children, inhaled steroids appear to be at least as effective as systemic steroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

11.

Anti-leukotriene agents compared to inhaled corticosteroids in the management of recurrent and/or chronic asthma.

Author: DucharmeF M, HicksG C

Improved lung function
Reduced asthma symptoms
Increased withdrawal risk

Anti-leukotriene agents were similar to inhaled corticosteroids in terms of the rate of exacerbations requiring systemic steroids. However, inhaled steroids produced better lung function, quality of life, and reduced symptoms, night awakenings, and need for rescue beta2-agonist.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Mometasone furoate administered once daily is as effective as twice-daily administration for treatment of mild-to-moderate persistent asthma.

Author: KempJ P, BerkowitzR B, MillerS D, MurrayJ J, NolopK, HarrisonJ E

Asthma control
Improved lung function

Mometasone furoate (MF) administered by dry-powder inhaler (DPI) is effective for treating mild-to-moderate persistent asthma in patients previously taking only inhaled beta(2)-adrenergic agonists. A total daily dose of 400 microg was equally effective when administered once daily or twice daily.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Inhaled beclomethasone versus placebo for chronic asthma.

Author: AdamsN P, BestallJ B, JonesP W

Inhaled beclomethasone diproprionate (BDP) has been a standard treatment for asthma for many years, alongside budesonide. Now, with new asthma medications becoming available, BDP is frequently used as a benchmark for comparing the effectiveness of these newer treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

Low-dose fluticasone propionate compared with montelukast for first-line treatment of persistent asthma: a randomized clinical trial.

Author: BusseW, RaphaelG D, GalantS, KalbergC, Goode-SellersS, SrebroS, EdwardsL, RickardK,

Asthma treatment
Improved lung function
Reduced rescue medication use

Low-dose fluticasone propionate (FP) was more effective than montelukast in treating persistent asthma in patients who remained symptomatic despite using short-acting beta2-agonists alone. A multicenter, randomized, double-blind study involving 533 patients found that FP resulted in greater improvements in lung function, decreased rescue albuterol use, and increased symptom-free days. The adverse event and asthma exacerbation profiles for both treatments were similar.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Early use of inhaled corticosteroids in the emergency department treatment of acute asthma.

Author: EdmondsM L, CamargoC A, PollackC V, RoweB H

Asthma treatment
Reduced admissions
Insufficient evidence

Inhaled steroids reduced admission rates in patients with acute asthma, but it is unclear if there is a benefit when used in addition to systemic corticosteroids. Further research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

The effectiveness of high-dose inhaled budesonide therapy in the treatment of acute asthma exacerbations in children.

Author: NuhoğluY, BahçecilerN N, BarlanI B, Müjdat BaşaranM

Effective treatment of asthma
Corticosteroid-induced side effects

Guidelines recommend using corticosteroids to treat severe asthma attacks that don’t improve within 24-36 hours of home treatment. While this treatment is unlikely to cause serious problems for infrequent asthma attacks, frequent use can lead to side effects such as adrenal suppression, growth delays, and bone thinning.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Holding chambers versus nebulisers for inhaled steroids in chronic asthma.

Author: CatesC J, AdamsN, BestallJ

Nebuliser efficacy
Insufficient evidence

Budesonide delivered via a Pari Inhalier Boy jet nebuliser was more effective than budesonide delivered via a large volume spacer in the treatment of chronic asthma. The nebuliser delivery led to higher peak expiratory flow values, lower rescue beta2 agonist use, and lower symptom scores. However, it is unclear whether this difference was due to the dose delivered or the delivery system.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

18.

Gold as an oral corticosteroid sparing agent in stable asthma.

Author: EvansD J, CullinanP, GeddesD M

Alternative therapy
Steroid sparing
Steroid side effects

Patients with severe asthma often rely on long-term oral corticosteroids, which can have serious side effects. Doctors are seeking alternative treatments to reduce the need for these medications. Gold compounds, which suppress the immune system and have benefits in other inflammatory conditions, are being investigated as a potential treatment for severe asthma, both for their potential effectiveness and to reduce steroid use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

19.

Troleandomycin as an oral corticosteroid steroid sparing agent in stable asthma.

Author: EvansD J, CullinanP, GeddesD M

Alternative therapy
Steroid sparing
Steroid side effects

Patients with severe asthma often need long-term oral steroids, which can have harmful side effects. Doctors are searching for alternatives to reduce steroid use. Troleandomycin, an antibiotic, may have additional properties that could be helpful in treating asthma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

Home intervention in the treatment of asthma among inner-city children.

Author: CarterM C, PerzanowskiM S, RaymondA, Platts-MillsT A

Asthma treatment

Asthma is a major health problem in Atlanta and other US cities, affecting school attendance, emergency room visits, and hospitalizations. While asthma management guidelines recommend reducing exposure to allergens, the practicality and effectiveness of this approach for children living in poverty have not been studied.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

21.

A double-blinded, randomized, placebo-controlled trial of cetirizine in preventing the onset of asthma in children with atopic dermatitis: 18 months' treatment and 18 months' posttreatment follow-up.

Author: WarnerJ O,

Prevention of asthma
Unclear long-term effects

Since asthma cannot be cured, preventing it is crucial. Atopic dermatitis (eczema) is a common condition that can lead to asthma. Two studies suggested that antihistamines may reduce the development of asthma while being used, especially in people with high levels of a certain antibody (IgE). However, more research is needed to determine if antihistamines truly prevent asthma or just suppress symptoms temporarily, as long-term follow-up after stopping treatment is missing.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Fluticasone propionate/salmeterol combination compared with montelukast for the treatment of persistent asthma.

Author: PearlmanDavid S, WhiteMartha V, LiebermanAllen K, PepsinPamela J, KalbergChris, EmmettAmanda, BowersBrian, RickardKathleen A, DorinskyPaul

Improved asthma control
Improved patient satisfaction

Fluticasone propionate and salmeterol combination product (FSC) is more effective than montelukast for initial maintenance therapy in patients with persistent asthma. FSC led to greater improvements in asthma control, symptom-free days, rescue-free days, and quality of life scores compared to montelukast.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

Holding chambers versus nebulisers for beta-agonist treatment of acute asthma.

Author: CatesC J, RoweB H, BaraA

Asthma treatment

While nebulizers are commonly used for asthma attacks, inhalers with spacers might be just as effective. Nebulizers are more expensive, require electricity, and need regular cleaning, making inhalers with spacers a potentially more practical option outside of hospitals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

Fluticasone for the treatment of symptomatic bronchial asthma in children treated with sodium cromogylate--a prospective, randomised trial.

Author: von BergA, GappaMonika, SteinkampG,

Asthma treatment

Children with persistent mild to moderate asthma need anti-inflammatory medications. Current guidelines recommend either sodium cromoglycate (SCG) or inhaled corticosteroids. If symptoms persist despite using SCG, corticosteroids are the next recommended treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Written individualised management plans for asthma in children and adults.

Author: ToelleB G, RamF S

Improved asthma outcomes
Contribution of components unclear

Many people with asthma don’t follow their treatment plans, which can lead to worse health outcomes. While comprehensive asthma care, including education, written plans, and regular check-ups, has shown benefits, the impact of each component has not been clearly established.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

The effectiveness of inhaled corticosteroids in the emergency department treatment of acute asthma: a meta-analysis.

Author: EdmondsMarcia L, CamargoCarlos A, PollackCharles V, RoweBrian H

Improved peak flow
Reduced hospital admissions
Less effective than systemic corticosteroids
No significant change in pulmonary function

This systematic review examined the role of inhaled corticosteroids (ICSs) in the management of acute asthma in 352 patients across 7 trials. Patients treated with ICSs were less likely to be admitted to the hospital (odds ratio 0.30; 95% confidence interval [CI] 0.16 to 0.57) and showed small improvements in peak expiratory flows (weighted mean difference 8%; 95% CI 3% to 13%). There is evidence of decreased admission rates for patients with acute asthma treated with ICSs. However, there is insufficient evidence that ICS therapy results in clinically important changes in pulmonary function when used in acute asthma, and there is insufficient evidence that ICSs alone are as effective as systemic corticosteroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

A health-related quality-of-life comparison of formoterol (Oxis) Turbuhaler plus budesonide (Pulmicort) Turbuhaler with budesonide Turbuhaler alone and noncorticosteroid treatment in asthma: a randomized clinical study in Russia.

Author: ChuchalinA G, SvenssonK, StåhlE, OvcharenkoS I, GoriachkinaL A, SidorenkoI V, TsoiA N,

Asthma treatment effective

Formoterol Turbuhaler plus budesonide Turbuhaler and budesonide Turbuhaler alone significantly improved the health-related quality of life (HRQL) of patients with mild to moderate asthma compared with noncorticosteroid treatment. Both treatments were effective in improving lung function, reducing symptoms, and decreasing the need for relief medication.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Randomised pragmatic comparison of UK and US treatment of acute asthma presenting to hospital.

Author: InnesN J, StockingJ A, DaynesT J, HarrisonB D W

Asthma treatment

While corticosteroids and inhaled beta-agonists are standard treatments for severe asthma attacks, there's no agreement on the best doses and how often to give them. American treatment plans often use higher initial doses of these medications than those used in the UK.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

Efficacy and safety of budesonide inhalation powder (Pulmicort Turbuhaler) during 52 weeks of treatment in adults and children with persistent asthma.

Author: TinkelmanDavid G, BronskyEdwin A, GrossGary, SchoenwetterWilliam F, SpectorSheldon L

Decreased oral corticosteroid use
Improved pulmonary function
Pharyngitis
Respiratory infection
Sinusitis

Budesonide inhalation powder was well tolerated and maintained improved pulmonary function and reduced oral corticosteroid use in patients with mild to severe persistent asthma. The long-term efficacy and safety of budesonide support its use for managing asthma in both adults and children.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Holding chambers versus nebulisers for beta-agonist treatment of acute asthma.

Author: CatesC C J, BaraA, CrillyJ A, RoweB H

Asthma treatment

While nebulizers are commonly used for asthma attacks, inhalers with spacers might be just as effective. Nebulizers are more expensive, require electricity, and need regular cleaning, making inhalers with spacers a potentially more practical option outside of hospitals.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

31.

Early use of inhaled corticosteroids in the emergency department treatment of acute asthma.

Author: EdmondsM L, CamargoC A, PollackC V, RoweB H

Improved lung function
Reduced hospital admission

Inhaled corticosteroids reduced admission rates in patients with acute asthma, but it is unclear if they are beneficial when used in addition to systemic corticosteroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

32.

A randomized, double-blind, double-dummy, parallel-group, multicenter, dose-reduction trial of the minimal effective doses of budesonide and fluticasone dry-powder inhalers in adults with mild to moderate asthma.

Author: KunaPiotr, JoubertJames R, GreefhorstLouis A P M, MagnussenHelgo

Asthma control
Lung function

This dose-response study found that the minimal effective doses (MEDs) of budesonide and fluticasone via dry-powder inhaler in adults with mild to moderate asthma were not statistically significantly different.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

33.

Written individualised management plans for asthma in children and adults.

Author: ToelleB G, RamF S F

Improved asthma outcomes
Contribution of components unclear

Many people with asthma don’t follow their treatment plans, which can lead to worse health outcomes. While comprehensive asthma care, including education, written plans, and regular check-ups, has shown benefits, the impact of each component has not been clearly established.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

Add-on therapy options in asthma not adequately controlled by inhaled corticosteroids: a comprehensive review.

Author: KankaanrantaHannu, LahdensuoAarne, MoilanenEeva, BarnesPeter J

Asthma treatment

Inhaled corticosteroids (ICS) are effective for many people with persistent asthma, but some still have symptoms. Research shows that adding a long-acting beta2-agonist (LABA) to ICS is more effective than increasing the ICS dose alone. Increasing the ICS dose may provide a small improvement, while adding a leukotriene antagonist (LTRA) or theophylline seems similar to doubling the ICS dose. LABA may be better than LTRA for lung function, but they may be similar for preventing asthma attacks. More research is needed on LTRAs and theophylline as add-on treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

35.

[Efficacy and acceptability of the fixed fluticasone + salmeterol combination in the treatment of acute asthma attacks. Results of a one-year comparative study].

Author: TonnelA-B, DesfougèresJ-L

Asthma control

The fixed fluticasone/salmeterol combination provided a protection equivalent to that obtained with free combinations over a one-year treatment period for asthma. It also showed a significant improvement in treatment acceptability.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

36.

Addition of formoterol or montelukast to low-dose budesonide: an efficacy comparison in short- and long-term asthma control.

Author: CeylanErkan, GencerMehmet, AksoySahin

Asthma treatment

Asthma is a long-term condition that causes inflammation in the airways. While inhaled corticosteroids are important for reducing inflammation, they often aren't enough to manage asthma on their own. Other medications, like long-acting beta2 agonists and leukotriene antagonists, are also used to control asthma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

37.

Step-down compared to fixed-dose treatment with inhaled fluticasone propionate in asthma.

Author: ForesiAntonio, MastropasquaBerardino, ChettaAlfredo, D'IppolitoRaffaele, TestiRenato, OlivieriDario, PelucchiAndrea

Asthma treatment

Inhaled corticosteroids (ICSs) are effective for asthma even at low doses. Once asthma is controlled, it's recommended to reduce the ICS dose to the lowest possible effective level. While the best way to reduce the dose isn't fully established, measuring eosinophils in sputum (mucus) and bronchial hyperresponsiveness (how sensitive the airways are) can help determine asthma control.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

39.

Comparison of the efficacy and safety of budesonide turbuhaler administered once daily with twice the dose of beclomethasone dipropionate using pressurised metered dose inhaler in patients with mild to moderate asthma.

Author: Ohaju-ObodoJ O, ChukwuC, OkpapiJ, EgbagbeE, IgeM O, ChukwukaC, AdedapoD A

Improved asthma management
Increased compliance
Bronchial asthma

Inhaled corticosteroids are a key treatment for asthma, but people often don't follow their complex medication schedules. Using a single daily dose with a simple inhaler like the turbuhaler might improve adherence and effectiveness.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

40.

The effect of nebulized budesonide treatment in children with mild to moderate exacerbations of asthma.

Author: SekerelBulent E, SackesenCansin, TuncerAyfer, AdaliogluGonul

Improve asthma

The effectiveness of inhaled corticosteroids in treating acute asthma in children was studied. While the level of improvement was similar between budesonide and placebo, budesonide showed a trend towards a benefit in preventing progression of the illness. Further research is needed to confirm the benefit.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

41.

Holding chambers versus nebulisers for inhaled steroids in chronic asthma.

Author: CatesC J, BestallJ, AdamsN

Improved lung function
Reduced rescue medication use

Budesonide delivered via a specific nebuliser was more effective than budesonide delivered via a holding chamber for the treatment of chronic asthma in adults. However, further studies are needed to evaluate the relative effectiveness of different nebuliser/compressor combinations compared to holding chambers, particularly in infants and pre-school children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

Impact of omalizumab on quality-of-life outcomes in patients with moderate-to-severe allergic asthma.

Author: NiebauerKimberly, DewildeSarah, Fox-RushbyJulia, RevickiDennis A

Asthma treatment

Moderate to severe asthma significantly affects people's quality of life, and many patients experience fluctuating asthma control despite following treatment guidelines. Omalizumab, a new medication, has been shown to be safe and effective for treating asthma triggered by IgE antibodies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma.

Author: CatesC J, CrillyJ A, RoweB H

Asthma treatment

While nebulizers are often used to deliver inhaled medication for asthma attacks, inhalers with spacers might be just as effective. Nebulizers require electricity and maintenance, and are more expensive outside of hospitals, making inhalers with spacers a potentially more convenient option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

44.

Linear growth in prepubertal asthmatic children treated with montelukast, beclomethasone, or placebo: a 56-week randomized double-blind study.

Author: BeckerAllan B, KuznetsovaOlga, VermeulenJ, Soto-QuirosManuel E, YoungBetty, ReissTheodore F, DassS Balachandra, KnorrBarbara A,

No effect on linear growth
Reduced beta-agonist use
Bone marker imbalance
Decreased growth rate

Montelukast did not affect linear growth in prepubertal asthmatic children, while beclomethasone was associated with a significant decrease in growth rate.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

46.

Effects of salmeterol in patients with persistent asthma receiving inhaled corticosteroid plus theophylline.

Author: InoueHiromasa, KomoriMasashi, MatsumotoTakafumi, FukuyamaSatoru, MatsumuraMikiko, NakanoTakako, TsudaMiyuki, MatsumotoKoichiro, KanayaAkiko, MoriwakiAtsushi, AizawaHisamichi, YoshidaMakoto, NakanishiYoichi

Increased FEV1

The study investigated the efficacy and safety of salmeterol combined with high-dose inhaled corticosteroids (ICSs) plus theophylline in patients with severe asthma. The results showed that salmeterol significantly increased FEV(1) compared to placebo, even in patients already receiving high-dose ICSs plus theophylline and a leukotriene receptor antagonist. This suggests that salmeterol may be a beneficial add-on therapy for patients with severe asthma who are not adequately controlled by other medications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

47.

Treatment with 400 microg of inhaled budesonide vs 200 microg of inhaled budesonide and oral montelukast in children with moderate persistent asthma: randomized controlled trial.

Author: JatGokul Chand, MathewJoseph L, SinghMeenu

Asthma control
Exacerbation frequency

The overall control of asthma with 5 mg of oral montelukast and 200 microg of inhaled budesonide is inferior to that with 400 microg of inhaled budesonide in children with moderate persistent asthma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

48.

Cost-effectiveness of omalizumab in patients with severe persistent allergic asthma.

Author: BrownR, TurkF, DaleP, BousquetJ

Asthma treatment
Cost-effective

This study determined the incremental cost-effectiveness ratio (ICER) of adding omalizumab to standard therapy using data from a real-life 1-year randomized open-label study (ETOPA) and using Canada as a reference country. The study demonstrated that add-on omalizumab therapy is cost-effective in patients with severe persistent allergic asthma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

49.

A website to improve asthma care by suggesting patient questions for physicians: qualitative analysis of user experiences.

Author: HartmannChristine W, SciamannaChristopher N, BlanchDanielle C, MuiSarah, LawlessHeather, ManocchiaMichael, RosenRochelle K, PietropaoliAnthony

Improved asthma treatment
Asthma

Asthma is a common chronic condition in the US, but despite guidelines, nearly three-quarters of patients don't have well-controlled asthma. This is partly due to doctors not changing treatment plans often enough. Research suggests that patients who request specific tests and treatments are more likely to receive them.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

50.

The use of exhaled nitric oxide to guide asthma management: a randomized controlled trial.

Author: ShawDominick E, BerryMike A, ThomasMike, GreenRuth H, BrightlingChris E, WardlawAndrew J, PavordIan D

Reduced asthma exacerbations
Increased corticosteroid use

Titrating corticosteroid dose using exhaled nitric oxide did not reduce asthma exacerbations or corticosteroid use compared to standard guidelines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

51.

Montelukast vs. inhaled low-dose budesonide as monotherapy in the treatment of mild persistent asthma: a randomized double blind controlled trial.

Author: KumarVikram, RameshP, LodhaRakesh, PandeyR M, KabraS K

Asthma control

Montelukast is as effective as inhaled budesonide in the treatment of mild persistent asthma in children aged 5-15 years.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

52.

Corticosteroids for preventing relapse following acute exacerbations of asthma.

Author: RoweB H, SpoonerC H, DucharmeF M, BretzlaffJ A, BotaG W

Reduced hospitalizations
Reduced relapse
No difference in side effects

A short course of corticosteroids following assessment for an asthma exacerbation significantly reduces the number of relapses to additional care, hospitalizations and use of short-acting beta(2)-agonist without an apparent increase in side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

53.

[Self-management program in treatment of asthma].

Author: MilenkovićBranislava, Bosnjak-PetroićVesna

Asthma management

Current asthma guidelines emphasize the importance of self-management for patients with asthma. These guidelines recommend personalized plans that help patients recognize early signs of worsening asthma by monitoring their lung function and symptoms.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Serbian

54.

Increasing doses of inhaled corticosteroids compared to adding long-acting inhaled beta2-agonists in achieving asthma control.

Author: O'ByrnePaul M, NayaIan P, KallenAnders, PostmaDirkje S, BarnesPeter J

Improved asthma treatment
Asthma

Combining inhaled corticosteroids (ICSs) and long-acting beta-agonists (LABAs), or increasing the dose of ICSs alone, improves asthma control when low-dose ICSs are not enough. However, it is unclear which approach is better for maintaining long-term control of asthma.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

55.

Efficacy and tolerability of salmeterol/fluticasone propionate versus montelukast in childhood asthma: A prospective, randomized, double-blind, double-dummy, parallel-group study.

Author: MasperoJorge, GuerraFrances, CuevasFrancisco, GutierrezJose Pablo, Soto-RamosMario, AndertonSally, MechaliDaniel, ChanRobert, PedersenSøren

Improved asthma control
Reduced exacerbations
Well tolerated
Headache

In children with uncontrolled asthma previously on short-acting beta(2)-agonist monotherapy, inhaled salmeterol/fluticasone propionate (SFC) was significantly more effective in improving asthma control and decreasing exacerbation rates than oral montelukast (MON). Both drugs were well tolerated.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

56.

Cost-effectiveness analysis of budesonide/formoterol maintenance and reliever therapy versus fixed combination treatments for asthma in Finland*.

Author: TamminenKlaus, LaineJuha, SoiniErkki, MartikainenJanne, KankaanrantaHannu

Reduced asthma exacerbations
None specified

Budesonide/formoterol maintenance and reliever therapy for moderate-to-severe asthma shows a high probability of cost-effectiveness compared to fixed combination therapies, with significantly reduced rates of severe asthma exacerbations.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

57.

Effects of fluticasone propionate and salmeterol hydrofluoroalkane inhalation aerosol on asthma-related quality of life.

Author: EdinHeather M, AndersenLeslie B, SchoafLynne, Scott-WilsonCatherine A, HoShu-Yen, OrtegaHector G

Asthma treatment
Improved well-being

Current asthma guidelines emphasize the importance of considering how asthma affects a person's daily life and ability to function, in addition to assessing the severity of the condition. Effective asthma management should lead to improvements in both well-being and physical function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

58.

Asthma in adults.

Author: DennisRodolfo J, SolarteIvan, FitzgeraldJ Mark

Asthma treatment

Asthma affects about 10% of adults, with 5% having severe asthma that is difficult to treat. Severe asthma is associated with increased risk of death, but those with milder asthma are also at risk of flare-ups. While many asthma management guidelines follow step-by-step approaches, this review presents evidence on specific treatments without endorsing any specific protocol.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

59.

Predicting short term response to anti-inflammatory therapy in young children with asthma.

Author: ZielenStefan, ChristmannMartin, KloskaMagdalena, Dogan-YildizGülben, LiebAdrian, RosewichMartin, SchubertRalf, RoseMarkus A, SchulzeJohannes

Asthma treatment
Episodic asthma treatment

Pre-bronchodilatory FEV1 and airway reversibility are good indicators of short-term anti-inflammatory therapy in young children with asthma. Both fluticasone and montelukast were equally effective in this age group.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

60.

Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children.

Author: QuonBradley S, FitzgeraldJ Mark, LemièreCatherine, ShahidiNeal, DucharmeFrancine M

Improved asthma control

A review of 5 randomized controlled trials (RCTs) involving 1250 patients with mild to moderate asthma assessed the effectiveness of increasing inhaled corticosteroids (ICS) at the onset of asthma exacerbations. In adults, increasing ICS doses to 1000 to 2000 mcg/day did not significantly reduce the need for rescue oral corticosteroids. Further research is needed to assess the effectiveness of increased ICS doses in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

61.

A randomized, open labeled, comparative study to assess the efficacy and safety of controller medications as add on to inhaled corticosteroid and long-acting β2 agonist in the treatment of moderate-to-severe persistent asthma.

Author: PatelY A, PatelP, BavadiaH, DaveJ, TripathiC B

Asthma treatment

The goal of asthma treatment is to manage the condition and restore near-normal lung function. Many people with persistent asthma don't achieve these goals with only one medication in addition to inhaled corticosteroids. This study examines whether adding another controller medication to inhaled corticosteroids and a long-acting bronchodilator helps people with asthma reach their goals.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

62.

Tiotropium bromide step-up therapy for adults with uncontrolled asthma.

Author: PetersStephen P, KunselmanSusan J, IcitovicNikolina, MooreWendy C, PascualRodolfo, AmeredesBill T, BousheyHomer A, CalhounWilliam J, CastroMario, CherniackReuben M, CraigTimothy, DenlingerLoren, EngleLinda L, DiMangoEmily A, FahyJohn V, IsraelElliot, JarjourNizar, KazaniShamsah D, KraftMonica, LazarusStephen C, LemanskeRobert F, LugogoNjira, MartinRichard J, MeyersDeborah A, RamsdellJoe, SorknessChristine A, SutherlandE Rand, SzeflerStanley J, WassermanStephen I, WalterMichael J, WechslerMichael E, ChinchilliVernon M, BleeckerEugene R,

Improved asthma symptoms
Improved lung function

This study compared the effects of adding tiotropium, a long-acting anticholinergic agent, to an inhaled glucocorticoid for treating uncontrolled asthma. Tiotropium was superior to doubling the dose of inhaled glucocorticoid and non-inferior to the addition of salmeterol in improving symptoms and lung function.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

63.

Comparison of the effect of low-dose ciclesonide and fixed-dose fluticasone propionate and salmeterol combination on long-term asthma control.

Author: PostmaDirkje S, O'ByrnePaul M, PedersenSøren

Asthma treatment

This study compared the effectiveness of two first-line treatments for mild asthma: ciclesonide and a combination of fluticasone and salmeterol. The study aimed to determine the best initial treatment option for this common type of asthma.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

64.

Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children.

Author: QuonBradley S, FitzgeraldJ Mark, LemièreCatherine, ShahidiNeal, DucharmeFrancine M

Increasing the dose of inhaled corticosteroids (ICS) at the onset of asthma exacerbations did not significantly reduce the need for rescue oral corticosteroids. In a review of 5 randomized controlled trials involving 1250 patients, there was no significant difference in the need for rescue oral corticosteroids between patients who increased their ICS dose and those who continued their usual maintenance dose.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

65.

Overall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps.

Author: BatemanEric D, HarrisonTim W, QuirceSantiago, ReddelHelen K, BuhlRoland, HumbertMarc, JenkinsChristine R, PetersonStefan, OstlundOllie, O'ByrnePaul M, SearsMalcolm R, ErikssonGöran S

Asthma treatment

This study examined the benefits of using a combination of budesonide and formoterol (BUD/FORM) as a maintenance and reliever therapy for asthma in patients whose asthma was not controlled with previous treatments, which were at different levels of severity according to asthma guidelines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

66.

Asthma in adults (acute).

Author: RodrigoGustavo

Asthma treatment

While most adults have experienced asthma, about 5% have severe asthma that doesn't respond well to treatment. Severe asthma increases the risk of death, but even mild to moderate asthma can lead to flare-ups. While many asthma management guidelines use a step-by-step approach, this review examines the evidence for specific interventions without endorsing any specific protocol.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

67.

Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma.

Author: DucharmeFrancine M, LassersonToby J, CatesChristopher J

Asthma control
Improved lung function
Improved quality of life
Exacerbations
Serious adverse events

In adults with asthma inadequately controlled on inhaled steroids and showing reversibility with beta(2)-agonists, LABA is superior to LTRA in reducing oral steroid treated exacerbations. There is some evidence of increased risk of SAEs with LABA.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

68.

Intermittent or daily montelukast versus placebo for episodic asthma in children.

Author: ValovirtaErkka, BozaMaria L, RobertsonColin F, VerbruggenNadia, SmugarSteven S, NelsenLinda M, KnorrBarbara A, ReissTheodore F, PhilipGeorge, GurnerDeborah M

Asthma symptom reduction

Montelukast did not reduce the number of asthma episodes culminating in an asthma attack over 1 year in children 6 months to 5 years of age.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

69.

Tiotropium improves lung function in patients with severe uncontrolled asthma: a randomized controlled trial.

Author: KerstjensHuib A M, DisseBernd, Schröder-BaboWinfried, BantjeTheo A, GahlemannMartina, SigmundRalf, EngelMichael, van NoordJan A

Lung function improvement
Dry mouth

Adding once-daily tiotropium to asthma treatment in patients with inadequately controlled, severe, persistent asthma significantly improves lung function over 24 hours. It was more effective than placebo with no significant difference between the two active doses.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

70.

Asthma in adults.

Author: DennisRodolfo J, SolarteIvan, RodrigoGustavo

Asthma treatment

While most adults have experienced asthma, about 5% have severe asthma that doesn't respond well to treatment. Severe asthma increases the risk of death, but even mild to moderate asthma can lead to flare-ups. This review examines the evidence for specific asthma treatments without endorsing any particular protocol.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

71.

WITHDRAWN: Written individualised management plans for asthma in children and adults.

Author: ToelleBrett, RamFelix Sf

Asthma treatment

Many people with asthma don't follow their treatment plans, which contributes to their health problems. While comprehensive asthma care, including education, self-management plans, and regular check-ups, improves outcomes, it's not clear which aspects of this care are most important.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

72.

Asthma in adults.

Author: DennisRodolfo J, SolarteIvan, RodrigoGustavo

Asthma treatment

While most adults have experienced asthma, about 5% have severe asthma that doesn't respond well to treatment. Severe asthma increases the risk of death, but even mild to moderate asthma can lead to flare-ups. This review examines the evidence for specific asthma treatments without endorsing any particular protocol.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

74.

Asthma control cost-utility randomized trial evaluation (ACCURATE): the goals of asthma treatment.

Author: HonkoopPersijn J, LoymansRik J B, TermeerEvelien H, Snoeck-StrobandJiska B, BakkerMoira J, AssendelftWillem J J, SterkPeter J, Ter RietGerben, SchermerTjard R J, SontJacob K

Treatment of asthma

Despite effective asthma treatments, asthma still causes significant health problems and healthcare costs. This study investigates whether using the highest doses of asthma medications for long periods is beneficial and if patients and society value the potential, but uncertain, benefits of such an approach. The study compares three treatment strategies aimed at achieving different levels of asthma control: 1) sufficient control, 2) strict control, and 3) strict control based on an additional marker of inflammation (exhaled nitric oxide). The study also assessed the cost-effectiveness of each approach.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

75.

Development and validation of the Composite Asthma Severity Index--an outcome measure for use in children and adolescents.

Author: WildfireJeremy J, GergenPeter J, SorknessChristine A, MitchellHerman E, CalatroniAgustin, KattanMeyer, SzeflerStanley J, TeachStephen J, BloombergGordon R, WoodRobert A, LiuAndrew H, PongracicJacqueline A, ChmielJames F, ConroyKathleen, Rivera-SanchezYadira, BusseWilliam W, MorganWayne J

Assessment of asthma severity

Asthma severity impacts many aspects of the disease, including limitations and the risk of future flare-ups. However, to fully understand asthma severity, the level of current treatment needed to control the condition should be considered.

Consensus Development Conference, NIHA conference organized by the NIH (National Institutes of Health) to develop consensus and recommendations on medical issues.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

76.

Asthma and other recurrent wheezing disorders in children (chronic).

Author: TurnerStephen William, FriendAmanda Jane, OkpapiAugusta

Treatment of childhood asthma

Asthma is the most common chronic illness in children. While there is no cure, effective treatments are available to manage symptoms. Children with a personal or family history of allergies, more frequent or severe wheezing episodes, and narrowed or sensitive airways are more likely to have asthma. Common triggers for asthma symptoms and flare-ups include infections, dust mites, pet allergies, exposure to smoke, and exercise.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

77.

Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children.

Author: WattsKirsty, ChavasseRichard J P G

Treatment of acute asthma

Severe asthma attacks that require emergency care often lead to hospital admission. While medications like corticosteroids, beta-agonists, and oxygen are commonly used, the effectiveness of antileukotriene drugs, which are helpful for long-term asthma management, is being studied for their use in treating acute asthma attacks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

78.

Salmeterol and fluticasone in young children with multiple-trigger wheeze.

Author: MäkeläMika J, MalmbergL Pekka, CsonkaPeter, KlemolaTimo, KajosaariMerja, PelkonenAnna S

Improved lung function

Salmeterol-fluticasone and fluticasone were comparable in efficacy in children with multiple-trigger wheeze. However, lung function improvement was better with salmeterol-fluticasone than fluticasone alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

79.

The effect of budesonide/formoterol maintenance and reliever therapy on the risk of severe asthma exacerbations following episodes of high reliever use: an exploratory analysis of two randomised, controlled studies with comparisons to standard therapy.

Author: BuhlRoland, KunaPiotr, PetersMatthew J, AnderssonTomas L G, NayaIan P, PetersonStefan, RabeKlaus F

Treatment of severe asthma

There are two main approaches to managing severe asthma. One uses high, fixed doses of maintenance medication, supplemented by a rescue inhaler as needed. The other uses a combination medication (budesonide/formoterol) for both maintenance and rescue use. The combination approach has been shown to reduce severe asthma attacks while achieving similar or better control compared to the fixed-dose approach. This study examines the risk of severe asthma attacks after a day of high rescue inhaler use.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

80.

Early use of inhaled corticosteroids in the emergency department treatment of acute asthma.

Author: EdmondsMarcia L, MilanStephen J, CamargoCarlos A, PollackCharles V, RoweBrian H

Reduced hospital admissions

Inhaled corticosteroids (ICS) were shown to reduce hospital admissions in patients with acute asthma, especially when combined with systemic corticosteroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

81.

Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults.

Author: ChauhanBhupendrasinh F, ChartrandCaroline, DucharmeFrancine M

Asthma control
Improved lung function
Growth suppression

This systematic review compared the efficacy and safety of intermittent versus daily ICS in the management of children and adults with persistent asthma. There was no statistically significant group difference in the risk of exacerbations requiring oral corticosteroids. Daily ICS was superior to intermittent ICS in several indicators of lung function, airway inflammation, asthma control, and reliever use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

82.

Intermittent versus daily inhaled corticosteroids for persistent asthma in children and adults.

Author: ChauhanBhupendrasinh F, ChartrandCaroline, DucharmeFrancine M

Improved lung function
Growth suppression

The review compared the efficacy and safety of intermittent versus daily inhaled corticosteroids (ICS) for persistent asthma. Intermittent and daily ICS were similarly effective in terms of exacerbations and serious adverse events. Daily ICS was superior in several indicators of lung function, asthma control, and reliever use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

83.

Combination formoterol and budesonide as maintenance and reliever therapy versus current best practice (including inhaled steroid maintenance), for chronic asthma in adults and children.

Author: CatesChristopher J, KarnerCharlotta

Asthma exacerbation reduction
Hospital admission reduction
ICS dosage reduction
Oral corticosteroid reduction
Adverse events
Study withdrawal

Single inhaler therapy (SiT) with budesonide and formoterol was shown to reduce the risk of asthma exacerbations needing oral corticosteroids compared to fixed dose maintenance inhaled corticosteroids (ICS) and separate relief medication. However, the evidence for SiT reducing hospitalization is weak. There were more discontinuations due to adverse events on SiT compared to current best practice, but no significant differences in serious adverse events.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

84.

Combined inhaled anticholinergics and short-acting beta2-agonists for initial treatment of acute asthma in children.

Author: GriffithsBenedict, DucharmeFrancine M

Asthma treatment

When asthma symptoms worsen suddenly and don't improve with usual treatment, children are typically given inhaled medications that quickly open airways (short-acting beta2-agonists, SABAs). Anticholinergics, another type of inhaler, have a slower effect but might help reduce airway narrowing and mucus. Combining anticholinergics with SABAs could potentially improve and prolong the opening of airways.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

85.

Holding chambers (spacers) versus nebulisers for beta-agonist treatment of acute asthma.

Author: CatesChristopher J, WelshEmma J, RoweBrian H

Inhaled beta(2)-agonists
Acute asthma

While nebulizers are often used to deliver inhaled medication for asthma attacks, inhalers with spacers might be just as effective. Nebulizers require electricity and maintenance, and are more expensive outside of hospitals, making inhalers with spacers a potentially more practical option.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

86.

Addition of anti-leukotriene agents to inhaled corticosteroids in children with persistent asthma.

Author: ChauhanBhupendrasinh F, Ben SalahRaja, DucharmeFrancine M

Asthma treatment

For children with persistent asthma, low-dose inhaled corticosteroids (ICS) are the recommended first-line treatment. When asthma isn't well-controlled with low-dose ICS, adding an anti-leukotriene medication is one option for increasing treatment intensity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

87.

Omalizumab for the treatment of severe persistent allergic asthma: a systematic review and economic evaluation.

Author: NormanG, FariaR, PatonF, LlewellynA, FoxD, PalmerS, CliftonI, PatonJ, WoolacottN, McKennaC

Allergic asthma treatment

Allergic asthma is a long-term lung condition triggered by allergens. People with poorly controlled asthma are at high risk for severe attacks requiring additional treatment, including hospitalization. Omalizumab is a medication used in people over 6 years old with severe allergic asthma who don't respond well to other treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

88.

Combination formoterol and budesonide as maintenance and reliever therapy versus combination inhaler maintenance for chronic asthma in adults and children.

Author: KewKayleigh M, KarnerCharlotta, MindusStephanie M, FerraraGiovanni

Asthma treatment

Asthma is a chronic lung condition with recurring episodes of wheezing, chest tightness, and coughing. Inhaled medications are often effective in controlling symptoms, preventing complications, and improving quality of life. While some medications are taken regularly and others for symptom relief, a single inhaler containing both a steroid and a bronchodilator is available (SiT or SMART therapy). This treatment may improve adherence to medication, reducing symptoms and exacerbations, but it's unclear whether it increases side effects from the steroid.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

89.

Budesonide nebulization added to systemic prednisolone in the treatment of acute asthma in children: a double-blind, randomized, controlled trial.

Author: AlangariAbdullah A, MalhisNidal, MubasherMohamed, Al-GhamediNajwa, Al-TannirMohamad, RiazMuhammad, UmetsuDale T, Al-TamimiSaleh

acute asthma treatment

Budesonide nebulization did not decrease hospital admission rates in children with acute asthma overall, but may decrease admission rates in children with severe acute asthma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

90.

Addition to inhaled corticosteroids of long-acting beta2-agonists versus anti-leukotrienes for chronic asthma.

Author: ChauhanBhupendrasinh F, DucharmeFrancine M

Asthma exacerbation reduction
Serious adverse events

This systematic review found that in adults with asthma inadequately controlled by inhaled corticosteroids (ICS), adding a long-acting beta2-agonist (LABA) to ICS is modestly superior to adding an anti-leukotriene (LTRA) in reducing oral corticosteroid-treated exacerbations. The absolute reduction in exacerbations was two percentage points. LABA was also superior to LTRA in improving lung function and reducing rescue medication use. However, there was a slightly increased risk of serious adverse events (SAE) with LABA compared to LTRA, with an absolute increase of one percentage point.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

91.

Tiotropium in the treatment of patients with asthma.

Author: RashidQura, KleinRobin

Improved spirometry
Reduced asthma exacerbations
Insufficient evidence for clinical outcomes

Tiotropium is an effective intervention for patients with moderate and severe asthma. Tiotropium was associated with improvement in spirometry and asthma exacerbations, but there is insufficient evidence to support improvements in asthma symptom measures, asthma control days, asthma-related quality-of-life-scores, or rescue inhaler use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

92.

Inhaled corticosteroids in children with persistent asthma: effects on growth.

Author: ZhangLinjie, PrietschSílvio O M, DucharmeFrancine M

Asthma treatment
Growth effects

Inhaled corticosteroids (ICS) are the recommended initial treatment for persistent asthma in children. While ICS are generally safe, concerns remain about potential side effects from regular use, especially the effects on growth.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

93.

Long-acting anticholinergic agents in patients with uncontrolled asthma: a systematic review and meta-analysis.

Author: LeeS W, KimH J, YooK H, ParkY B, ParkJ-Y, JungJ Y, MoonJ-Y, ByunM K, KimS W, KimY H

Improved QoL
Improved lung function
Reduced exacerbations

This review assessed the benefits of tiotropium in patients with poorly controlled asthma. The addition of tiotropium to inhaled corticosteroids resulted in improvements in lung function, reduced risk of severe exacerbation, and improved quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

94.

Markers of Differential Response to Inhaled Corticosteroid Treatment Among Children with Mild Persistent Asthma.

Author: GeraldJoe K, GeraldLynn B, VasquezMonica M, MorganWayne J, BoehmerSusan J, LemanskeRobert F, MaugerDavid T, StrunkRobert C, SzeflerStanley J, ZeigerRobert S, BacharierLeonard B, BadeElizabeth, CovarRonina A, GuilbertTheresa W, Heidarian-RaissyHengameh, KellyH William, Malka-RaisJonathan, SorknessChristine A, TaussigLynn M, ChinchilliVernon M, MartinezFernando D

Improved asthma control

Children with mild persistent asthma who have markers of atopic asthma or who have greater asthma burden may obtain greater benefit from beclomethasone therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

95.

Magnitude of effect of asthma treatments on Asthma Quality of Life Questionnaire and Asthma Control Questionnaire scores: Systematic review and network meta-analysis.

Author: BatemanEric D, EsserDirk, ChirilaCostel, FernandezMaria, FowlerAndy, Moroni-ZentgrafPetra, FitzGeraldJ Mark

Asthma treatment

Two commonly used asthma questionnaires, the AQLQ and ACQ, often don't show significant improvements in patients taking new asthma medications compared to those on placebo, especially when the new drug is added to existing treatments. This means the improvements are not large enough to be considered clinically meaningful.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

96.

Stopping long-acting beta2-agonists (LABA) for children with asthma well controlled on LABA and inhaled corticosteroids.

Author: KewKayleigh M, BeggsSean, AhmadShaleen

Asthma treatment

Asthma is a common chronic condition in children, often leading to preventable attacks that require extra treatment. Inhaled corticosteroids (ICS) are the first-line treatment, and when symptoms aren't well-controlled, long-acting beta2-agonists (LABAs) are often added. However, there is a warning about using LABAs for as short a time as possible, stopping them once asthma is controlled.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

97.

Long-acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus addition of long-acting beta2-agonists (LABA) for adults with asthma.

Author: KewKayleigh M, EvansDavid J W, AllisonDebbie E, BoyterAnne C

Asthma treatment

Uncontrolled asthma puts a strain on healthcare, leading to frequent hospital visits and additional medication. While long-acting beta2-agonists (LABAs) are commonly added to inhaled corticosteroids (ICS) for those with uncontrolled asthma, they have safety concerns. Long-acting muscarinic antagonists (LAMAs) are now being considered as a potential alternative for those with asthma who don't respond well to ICS alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

98.

The Combined Impact of Exhaled Nitric Oxide and Sputum Eosinophils Monitoring in Asthma Treatment: A Prospective Cohort Study.

Author: MalerbaMario, RadaeliAlessandro, OliviniAlessia, RagnoliBeatrice, RicciardoloFabio, MontuschiPaolo

Asthma control improvement

This study compared the effectiveness of asthma control using fraction of exhaled nitric oxide (FENO) and sputum eosinophils versus a clinical score. The intervention group had a significant reduction in exacerbation rate by 73% at 12 months and 84% at 24 months, compared to the control group. The intervention group also had a significantly lower symptom score at 24 months. Both groups had an increase in inhaled corticosteroid (ICS) dose, but there was no difference between groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

99.

Intermittent inhaled corticosteroid therapy versus placebo for persistent asthma in children and adults.

Author: ChongJimmy, HaranCheyaanthan, ChauhanBhupendrasinh F, AsherInnes

Asthma treatment

Guidelines recommend using inhaled corticosteroids (ICS) daily for asthma, but many patients don't use them consistently. Recent research suggests that starting ICS when symptoms first appear, rather than taking them daily, may still be helpful in managing asthma attacks.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

100.

Long-acting muscarinic antagonists (LAMA) added to combination long-acting beta2-agonists and inhaled corticosteroids (LABA/ICS) versus LABA/ICS for adults with asthma.

Author: KewKayleigh M, DahriKaren

Asthma treatment

Combination medications for asthma, like long-acting beta2-agonists and inhaled corticosteroids (LABA/ICS), can help control symptoms and reduce flare-ups. However, some people don't achieve good control with these medications. A new type of inhaler, long-acting muscarinic antagonists (LAMA), used successfully for lung disease, is now being used for asthma alongside LABA/ICS.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

101.

A perspective on systemic corticosteroid therapy in severe bronchial asthma in adults.

Author: KlaustermeyerWilliam B, ChoiSoo H

Effective asthma treatment
Corticosteroid toxicity

Systemic corticosteroids are still required for the treatment of severe asthma, and their use should be guided by frequent measures of peak expiratory flow rate and forced expiratory flow in 1 second.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

102.

Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children.

Author: KewKayleigh M, QuinnMichael, QuonBradley S, DucharmeFrancine M

Asthma treatment

Asthma patients may experience worsening symptoms (exacerbations). Written action plans often recommend doubling inhaled steroids early in an exacerbation to reduce severity, potentially preventing the need for oral steroids or hospitalization.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

103.

Tiotropium improves lung function, exacerbation rate, and asthma control, independent of baseline characteristics including age, degree of airway obstruction, and allergic status.

Author: KerstjensHuib A M, Moroni-ZentgrafPetra, TashkinDonald P, DahlRonald, PaggiaroPierluigi, VandewalkerMark, SchmidtHendrik, EngelMichael, BatemanEric D

Improved asthma symptom control
Improved lung function
Reduced asthma exacerbations

Tiotropium add-on to inhaled corticosteroids (ICS) plus a long-acting β2-agonist (LABA) improved lung function, reduced asthma exacerbations, and improved asthma symptom control in patients with severe symptomatic asthma, regardless of baseline characteristics.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

104.

No evidence of large genetic effects on steroid response in asthma patients.

Author: MostellerMichael, HoskingLouise, MurphyKay, ShenJudong, SongKijoung, NelsonMatthew, GhoshSoumitra

Asthma control

This pharmacogenetic study of 2672 ICS-treated patients with asthma did not find any evidence to support previously reported associations between candidate genetic variants and ICS response. The study analyzed over 9.8 million common genetic variants.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

105.

Exhaled nitric oxide levels to guide treatment for children with asthma.

Author: PetskyHelen L, KewKayleigh M, ChangAnne B

Asthma treatment

Asthma guidelines recommend using the lowest effective dose of medication to control asthma symptoms, improve lung function, and prevent serious episodes. Fractional exhaled nitric oxide (FeNO) is a marker of inflammation in the airways. Tailoring asthma treatments based on levels of airway inflammation may improve asthma control and reduce severe episodes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

106.

Patient- and parent-initiated oral steroids for asthma exacerbations.

Author: GanaieMuhammad B, MunavvarM, GordonMorris, LimHui F, EvansDavid Jw

Asthma treatment

Asthma is a common condition affecting over 300 million people. When asthma symptoms worsen, people may need to go to a hospital for treatment with corticosteroids, either given intravenously or orally. Some asthma patients are prescribed oral corticosteroids (OCS) to take themselves or give to their children in case of an asthma attack. This approach is becoming more common.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

107.

Noninvasive ventilation for acute exacerbations of asthma: A systematic review of the literature.

Author: GreenElyce, JainParas, BernothMaree

Asthma treatment

Asthma is a chronic lung condition that causes wheezing, shortness of breath, and chest tightness. Severe asthma attacks often require hospitalization, placing a strain on health resources. This study explores the use of noninvasive ventilation (a breathing machine) as a potential treatment for severe asthma attacks due to its ability to open airways, deliver oxygen, and reduce breathing effort.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

108.

Systems biology and in vitro validation identifies family with sequence similarity 129 member A (FAM129A) as an asthma steroid response modulator.

Author: McGeachieMichael J, ClemmerGeorge L, HayeteBoris, XingHeming, RungeKarl, WuAnn Chen, JiangXiaofeng, LuQuan, ChurchBruce, KhalilIya, TantisiraKelan, WeissScott

Asthma steroid response

FAM129A is associated with variation in clinical asthma steroid responsiveness.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

109.

Allergen-Specific Immunotherapy in the Treatment of Pediatric Asthma: A Systematic Review.

Author: RiceJessica L, DietteGregory B, Suarez-CuervoCatalina, BrighamEmily P, LinSandra Y, RamanathanMurugappan, RobinsonKaren A, AzarAntoine

Improved quality of life
Reduced medication use
Allergic reactions
Anaphylaxis

This systematic review examined the efficacy and safety of subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT) in pediatric allergic asthma. 40 studies were included. SCIT may reduce long-term asthma medication use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

110.

Tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils): a systematic review and meta-analysis.

Author: PetskyHelen L, CatesChris J, KewKayleigh M, ChangAnne B

Asthma treatment
Eosinophilic endotype

Asthma guidelines recommend using the lowest dose of medication needed to control asthma symptoms. Many people with asthma have a type of inflammation involving eosinophils (a type of white blood cell). Tailoring asthma treatment based on levels of these cells in the airways could improve outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

111.

Intramuscular versus oral corticosteroids to reduce relapses following discharge from the emergency department for acute asthma.

Author: KirklandScott W, CrossElfriede, CampbellSandra, Villa-RoelCristina, RoweBrian H

Acute asthma treatment
Systemic corticosteroids

Severe asthma attacks are common reasons for emergency room visits. While most people can go home, many experience another attack requiring more treatment. Corticosteroids are often used to treat moderate to severe asthma, but the best way to give them for people discharged from the ER is unclear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

112.

Antibiotics for exacerbations of asthma.

Author: NormansellRebecca, SayerBen, WatersonSamuel, DennettEmma J, Del FornoManuela, DunleavyAnne

Asthma treatment
Exacerbation management

Asthma is a common lung condition affecting millions of people worldwide. Asthma symptoms can worsen, leading to serious episodes (exacerbations) that may require hospitalization. While antibiotics are sometimes used, they are only recommended when there is clear evidence of a bacterial infection, as bacteria are thought to be responsible for only a small number of asthma exacerbations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

113.

Impact of a single 10 min education session on asthma control as measured by ACT.

Author: SchuermansD, HanonS, WautersI, VerbanckS, VandevoordeJ, VanderhelstE

Asthma treatment
Educational session

This study investigates whether a single educational session can improve asthma control in patients. The study assessed asthma control using the Asthma Control Test (ACT) score and evaluated understanding of inhaler devices, medication, and inhaler technique.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

114.

Dexamethasone versus prednisone for children receiving asthma treatment in the paediatric inpatient population: protocol for a feasibility randomised controlled trial.

Author: PoundCatherine M, McDonaldJaime, TangKen, SeidmanGillian, JettyRadha, ZaidiSarah, PlintAmy C

Asthma exacerbations treatment
Corticosteroids

Asthma attacks are a common reason for children to be hospitalized. While corticosteroids are important for treating these attacks, the standard 5-day course of prednisone or prednisolone can be difficult for children to take due to taste and vomiting. Some hospitals use a shorter course of dexamethasone, but there is no strong evidence to support this practice in hospitalized children. This study aims to investigate the use of dexamethasone for treating children with asthma in the hospital.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Pragmatic Clinical TrialA trial conducted in a real-world clinical setting. It evaluates the effectiveness of interventions in everyday healthcare environments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

115.

Tiotropium Is Efficacious in 6- to 17-Year-Olds with Asthma, Independent of T2 Phenotype.

Author: SzeflerStanley J, VogelbergChristian, BernsteinJonathan A, GoldsteinStanley, MansfieldLyndon, Zaremba-PechmannLiliana, EngelMichael, HamelmannEckard

Asthma improvement
Lung function improvement

Tiotropium, used as an add-on therapy for children with asthma, improved lung function regardless of blood eosinophil counts or serum IgE levels. These findings suggest that tiotropium may be beneficial for a wide range of asthma patients.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

116.

The reality of LAMAs for adult asthmatic patients.

Author: LuzMaria Inês, AguiarRita, Morais-AlmeidaMário

Asthma treatment

Tiotropium is a medication used for asthma. Other medications called long-acting muscarinic antagonists (LAMAs), like umeclidinium and glycopyrronium, are being studied as add-on treatments for asthma. Using two medications that work in different ways might be helpful for people whose asthma isn't well-controlled, but more research is needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

117.

Interventions for escalation of therapy for acute exacerbations of asthma in children: an overview of Cochrane Reviews.

Author: CraigSimon S, DalzielStuart R, PowellColin Ve, GraudinsAndis, BablFranz E, LunnyCarole

Asthma treatment

Asthma is a common problem for both adults and children, often leading to trips to the emergency room. Asthma attacks can be triggered by colds, missed medications, weather changes, or allergens. Most children with asthma attacks improve with initial treatments like inhaled medications and steroids, but there's no clear best approach for the small number of kids who don't get better. Since there are many treatment options, care varies widely.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

118.

Combination fixed-dose beta agonist and steroid inhaler as required for adults or children with mild asthma.

Author: CrossinghamIain, TurnerSally, RamakrishnanSanjay, FriesAnastasia, GowellMatthew, YasminFarhat, RichardsonRebekah, WebbPhilip, O'BoyleEmily, HinksTimothy Sc

Asthma treatment

Asthma affects millions worldwide, with a significant number having mild disease. While inhalers containing bronchodilators (for quick relief) and inhaled corticosteroids (for long-term prevention) are common treatments, many people don't use them consistently, increasing the risk of severe asthma episodes. Combination inhalers that deliver both types of medication in one device may improve adherence and potentially benefit people with mild asthma, although this is still being researched.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

119.

A Systematic Review of the Effect of Physical Activity on Asthma Outcomes.

Author: KuderMargaret M, ClarkMaureen, CooleyCaitlin, Prieto-CenturionValentin, DanleyAdam, RileyIsaretta, SiddiqiAminaa, WellerKatherine, KitsiouSpyros, NyenhuisSharmilee M

Improved asthma control
Improved lung function
Improved quality of life
Reduced inflammation
Limited evidence

Physical activity may improve asthma control, quality of life, lung function, and inflammatory serologies, but further high-quality randomized controlled trials are needed to confirm these benefits.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

120.

Management of asthma exacerbations in the paediatric population: a systematic review.

Author: MantiSara, LicariAmelia, LeonardiSalvatore, MarsegliaGian Luigi

Asthma exacerbation management

Asthma attacks in children are a common reason for urgent care visits and hospitalizations. While there are guidelines for treating asthma attacks, the way they are actually treated in practice varies greatly, leading to inconsistencies in diagnosis and treatment decisions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

121.

Evaluation of Budesonide-Formoterol for Maintenance and Reliever Therapy Among Patients With Poorly Controlled Asthma: A Systematic Review and Meta-analysis.

Author: BeasleyRichard, HarrisonTim, PetersonStefan, GustafsonPer, HamblinAngus, BengtssonThomas, FageråsMalin

SMART and inhaled corticosteroid-long-acting β2-agonist for asthma

The Global Initiative for Asthma (GINA) recommends two different treatment approaches for people with asthma who need more intense therapy: using a single inhaler that combines a corticosteroid and formoterol, which can be used both for ongoing control and for quick relief of symptoms, or using a corticosteroid for ongoing control and a separate reliever medication for quick relief.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

122.

Increased versus stable doses of inhaled corticosteroids for exacerbations of chronic asthma in adults and children.

Author: KewKayleigh M, FlemyngElla, QuonBradley S, LeungClarus

Asthma treatment

Asthma attacks require additional treatment. Some asthma action plans recommend increasing the dose of inhaled medication at the first sign of an attack to prevent the need for stronger medications or hospitalization.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

123.

A Randomized Trial of a Composite T2-Biomarker Strategy Adjusting Corticosteroid Treatment in Severe Asthma: A Post Hoc Analysis by Sex.

Author: EastwoodMatthew C, BusbyJohn, JacksonDavid J, PavordIan D, HanrattyCatherine E, DjukanovicRatko, WoodcockAshley, WalkerSamantha, HardmanTimothy C, ArronJoseph R, ChoyDavid F, BraddingPeter, BrightlingChris E, ChaudhuriRekha, CowanDouglas, MansurAdel H, FowlerStephen J, HowarthPeter, LordanJames, Menzies-GowAndrew, HarrisonTimothy, RobinsonDouglas S, HolwegCecile T J, MatthewsJohn G, HeaneyLiam G,

Asthma treatment
Symptom/biomarker dissociation

This post hoc analysis examined the effects of sex on outcomes in a clinical trial comparing biomarker-defined corticosteroid (CS) treatment with standard care for severe asthma. Females achieved a greater benefit from biomarker-directed CS optimization than males, suggesting that sex-specific treatment considerations may be necessary in severe asthma.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

124.

Addition of long-acting beta2 agonists or long-acting muscarinic antagonists versus doubling the dose of inhaled corticosteroids (ICS) in adolescents and adults with uncontrolled asthma with medium dose ICS: a systematic review and network meta-analysis.

Author: ObaYuji, AnwerSumayya, PatelTarang, MadukeTinashe, DiasSofia

Asthma control

Inhaled corticosteroids (ICS) are the main treatment for persistent asthma. If ICS don't control asthma, treatment is usually increased by adding another medication (a long-acting beta2-agonist or LABA or a long-acting muscarinic antagonist or LAMA) or doubling the dose of ICS.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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