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Reproductive events modify the effects of estrogen replacement therapy on cognition in healthy postmenopausal women.

Author: AltshulerLori, DavidSteven, DunkinJennifer, RapkinAndrea, RasgonNatalie, Wagner-StehKristi

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Estrogen replacement therapy (ERT) may have a positive effect on executive functioning in more recently postmenopausal women, but further research is needed to confirm this effect.
Paper Details　
Original Abstract of the Article :
The question of whether estrogen replacement therapy (ERT) is beneficial to cognitive functioning in postmenopausal women has become controversial in the past several years. Early studies suggested that ERT improved cognitive functioning and decreased the risk of Alzheimer's disease, but recent stud...See full text at original site
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引用元：
https://doi.org/10.1016/j.psyneuen.2004.09.002

データ提供：米国国立医学図書館（NLM）

Estrogen Replacement Therapy and Cognition: The Role of Reproductive Events

Estrogen replacement therapy (ERT) is a common treatment for menopausal symptoms. However, its impact on cognitive functioning in postmenopausal women has been a subject of ongoing debate. This research examines the potential benefits and limitations of ERT on cognition, taking into account factors such as age, estrogen preparation, and the presence of concurrent progesterone administration.

Estrogen Replacement Therapy and Cognitive Functioning

The study's findings suggest that ERT's impact on cognition may vary depending on factors like age and reproductive events. The researchers found that years since menopause was significantly related to changes in executive functioning, indicating that more recently postmenopausal women may experience greater cognitive benefits from ERT compared to older women. This suggests that the timing of menopause and individual hormonal profiles may play a role in how ERT affects cognitive function.

Understanding the Individualized Effects of ERT

This study highlights the importance of considering individual factors when evaluating the potential benefits of ERT. The findings suggest that age and reproductive events can influence the effects of ERT on cognition, underscoring the need for individualized approaches to treatment. Further research is warranted to better understand the complex interplay between ERT, cognitive function, and individual physiological factors.

Dr. Camel's Conclusion

Just as a camel's journey through the desert is influenced by factors like the terrain and the weather, the effectiveness of ERT on cognitive function may be influenced by various factors, including age and reproductive events. This study provides valuable insights into the complexities of ERT, emphasizing the need for individualized approaches and further research to fully understand its potential impact on cognitive function.

Date :
  1. Date Completed 2005-02-17
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

15511602

DOI: Digital Object Identifier

10.1016/j.psyneuen.2004.09.002

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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