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The pharmacokinetics and effects of prochlorperazine in elderly female volunteers.

Author: BatemanD N, IsahA O, RawlinsM D

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Prochlorperazine, an antiemetic, showed similar pharmacokinetics in healthy elderly women compared to younger subjects after intravenous administration. Oral bioavailability was low, and prochlorperazine exerted both antidopaminergic and anticholinergic effects.
Paper Details　
Original Abstract of the Article :
The pharmacokinetics and effects of prochlorperazine (PCZ) have been studied in six healthy elderly female volunteers in a double-blind placebo-controlled study of 3.125 mg intravenous (IV) and 25 mg oral PCZ. The pharmacokinetics of IV PCZ in elderly subjects appear similar to those previously obta...See full text at original site
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引用元：
https://doi.org/10.1093/ageing/21.1.27

データ提供：米国国立医学図書館（NLM）

Prochlorperazine in the Elderly: Exploring Pharmacokinetics and Effects

Prochlorperazine, a medication commonly used to treat nausea and vomiting, can have different effects in different populations. This research investigates the pharmacokinetics and effects of prochlorperazine in elderly female volunteers, aiming to understand potential age-related differences in drug response.

A Journey Through Time: Exploring Age-Related Differences in Pharmacokinetics

The authors conducted a double-blind placebo-controlled study involving six healthy elderly female volunteers. They found that the pharmacokinetics of intravenous prochlorperazine in elderly subjects appeared similar to those observed in younger subjects. However, they noted that oral bioavailability was significantly lower in the elderly, suggesting that age-related changes in drug absorption might occur. This finding emphasizes the importance of considering age-related factors when prescribing prochlorperazine.

A Shifting Landscape: Understanding Age-Related Differences in Drug Effects

The researchers also explored the pharmacological actions of prochlorperazine in the elderly, finding evidence of antidopaminergic and anticholinergic effects. These findings highlight the potential for age-related differences in drug effects, suggesting the need for careful monitoring and dose adjustments when prescribing prochlorperazine to older adults. They also observed a trend towards prolonged reaction time in the elderly, raising concerns about potential cognitive effects.

Dr. Camel's Conclusion

This research, like a journey through a desert of age-related changes, highlights the importance of considering age-related factors when prescribing prochlorperazine to older adults. The authors' findings suggest that while the pharmacokinetics of intravenous prochlorperazine may be similar between age groups, oral bioavailability and drug effects may differ. This research underscores the need for careful monitoring and dose adjustments to optimize treatment outcomes and minimize potential adverse effects.
Date :
  1. Date Completed 1992-04-29
  2. Date Revised 2019-05-09
Further Info :

Pubmed ID

1553856

DOI: Digital Object Identifier

10.1093/ageing/21.1.27

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Languages

English

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