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Topical delivery of therapeutic agents in the treatment of inflammatory bowel disease.

Author: KlotzUlrich, SchwabMatthias

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the challenges of delivering therapeutic agents to the intestines for inflammatory bowel disease (IBD). While aminosalicylates and corticosteroids are used, individual variations in intestinal physiology and drug disposition lead to variable responses (35-75%). Different formulations of 5-aminosalicylate (5-AS) are available, including azo-prodrugs and rectal administration, but effectiveness varies based on disease location and patient characteristics. Budesonide, a corticosteroid, offers topical delivery and effectiveness without significant side effects. Topical delivery approaches will likely continue to be explored for new IBD therapies.
Paper Details　
Original Abstract of the Article :
For targeting local and systemic inflammatory processes in inflammatory bowel disease (IBD) therapeutic agents of first choice (e.g. aminosalicylates, corticosteroids) have been developed in special galenic forms to accomplish the topical delivery of the active compounds to the terminal ileum (Crohn...See full text at original site
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引用元：
https://doi.org/10.1016/j.addr.2004.08.007

データ提供：米国国立医学図書館（NLM）

Targeting Inflammatory Bowel Disease: The Promise of Topical Delivery

Inflammatory bowel disease (IBD), a group of chronic inflammatory conditions affecting the digestive tract, can significantly impact quality of life. This study explores the use of topical delivery methods for therapeutic agents in the treatment of IBD. The authors discuss the advantages of targeting specific areas of the digestive tract with medications, highlighting the potential for improved efficacy and reduced systemic side effects. They discuss various topical formulations of aminosalicylates and corticosteroids, specifically focusing on budesonide, a corticosteroid that has demonstrated efficacy in treating IBD with minimal systemic absorption.

Topical Delivery: A Targeted Approach to IBD Treatment

This study highlights the potential benefits of topical delivery methods in treating IBD. It's like finding a hidden spring in the desert, allowing for targeted irrigation of specific areas without affecting the surrounding ecosystem.

Managing IBD: A Personalized Approach

The study emphasizes the importance of considering individual patient characteristics and disease severity when choosing the most appropriate treatment approach for IBD. Topical delivery methods offer a personalized approach, allowing for targeted treatment of specific areas of the digestive tract. It's like tailoring a journey through the desert, selecting the most suitable path based on the traveler's needs and the terrain.

Dr. Camel's Conclusion

This research underscores the potential of topical delivery methods in improving the management of inflammatory bowel disease. By targeting specific areas of the digestive tract with medications, we can potentially enhance efficacy and minimize systemic side effects. Just as a desert traveler carefully considers the most effective route, we must strive to personalize treatment approaches for each patient, ensuring the optimal balance of effectiveness and safety.

Date :
  1. Date Completed 2005-03-23
  2. Date Revised 2006-11-15
Further Info :

Pubmed ID

15555742

DOI: Digital Object Identifier

10.1016/j.addr.2004.08.007

SNS
PICO Info
in preparation
Languages

English

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