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[Effects of tizanidine for refractory sleep disturbance in disabled children with spastic quadriplegia].

Author: ChoKazuhiko, FujiedaKenji, FukudaIkue, MiyamotoAkie, OkaRyuji, TanakaHajime

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Overview

This study investigated the effectiveness of tizanidine, a centrally acting alpha-2 adrenoreceptor agonist, for treating sleep disturbance in spastic quadriplegic children. Tizanidine improved sleep induction and/or maintenance in 61.9% of patients, with minimal side effects. The authors suggest that tizanidine's effects on muscle relaxation and sleep induction may contribute to its effectiveness in this population.
Paper Details　
Original Abstract of the Article :
Tizanidine is a centrally acting alpha-2 adrenoreceptor agonist widely used in the treatment of spasticity in patients with cerebral or spinal injury, and it is causing drawsiness in some of them. Based on these drug actions, we administered tizanidine to 21 spastic quadriplegic children with severe...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15560387

データ提供：米国国立医学図書館（NLM）

Tizanidine: A Potential Solution for Refractory Sleep Disturbances in Spastic Quadriplegia

Sleep disturbances are a common challenge for children with spastic quadriplegia. This study explores the potential of tizanidine, a centrally acting alpha-2 adrenoreceptor agonist, to address refractory sleep disturbances in this patient population. Like a skilled camel navigating a challenging desert terrain, this research explores innovative approaches to improving the quality of life for individuals with complex medical conditions.

Tizanidine: Promoting Sleep and Muscle Relaxation

The study found that tizanidine was effective in improving sleep induction and/or maintenance in a significant proportion of children with spastic quadriplegia. This suggests that tizanidine's effects on muscle relaxation and sleep promotion could be beneficial for individuals with refractory sleep disturbances.

Improving Sleep Quality in Spastic Quadriplegia

This study provides valuable insights into the potential benefits of tizanidine for managing sleep disturbances in children with spastic quadriplegia. It highlights the importance of addressing underlying factors, such as muscle hypertonia, to improve sleep quality and overall well-being.

Dr. Camel's Conclusion

Tizanidine emerges as a potential oasis in the desert of sleep disturbances for children with spastic quadriplegia. This study encourages further exploration of its role in managing sleep difficulties and improving the quality of life for this patient population.

Date :
  1. Date Completed 2005-02-01
  2. Date Revised 2018-02-22
Further Info :

Pubmed ID

15560387

DOI: Digital Object Identifier

15560387

SNS
PICO Info
in preparation
Languages

Japanese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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