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Granisetron: an update on its clinical use in the management of nausea and vomiting.

Author: AaproMatti

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This article provides an update on the use of the 5-HT3 receptor antagonist granisetron for managing nausea and vomiting induced by chemotherapy, radiation therapy, and surgical procedures. Granisetron has proven effective and well-tolerated in various patient populations, including those refractory to other antiemetics, those with hepatic or renal impairment, and children. Its safety profile and minimal drug interactions make it a preferred option for elderly cancer patients.
Paper Details　
Original Abstract of the Article :
Nausea and vomiting are typical side effects of cytotoxic therapy and some surgical procedures. These symptoms can represent a major therapeutic challenge and, if inadequately controlled by antiemetic treatment, will result in increased mortality, morbidity, and health care costs. However, the manag...See full text at original site
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引用元：
https://doi.org/10.1634/theoncologist.9-6-673

データ提供：米国国立医学図書館（NLM）

Granisetron: A Powerful Tool for Nausea and Vomiting Management

The struggle with [nausea and vomiting], particularly as a [side effect of chemotherapy or surgery], can be debilitating. This review explores the role of [granisetron] in managing these symptoms, highlighting its [effectiveness and safety] as a [5-HT3 receptor antagonist]. The authors provide an update on the [clinical experience] with [granisetron] and discuss its use in [various clinical settings] and [patient populations].

Granisetron: A Reliable Antiemetic Option

This review emphasizes the significant role of [granisetron] in managing [chemotherapy-induced, radiation-induced, and postoperative nausea and vomiting]. Its [potent and highly selective] action on [5-HT3 receptors] has made it a [well-tolerated and effective] antiemetic agent, particularly in [special populations] such as [patients refractory to antiemetic treatment, patients with hepatic or renal impairment, and children].

Easing the Burden of Nausea and Vomiting

The use of [granisetron] has greatly improved the [management of nausea and vomiting], significantly reducing the [burden of these debilitating symptoms] for patients undergoing [chemotherapy or surgery]. This review provides valuable information for both [patients and healthcare professionals], highlighting the [efficacy and safety] of [granisetron] as a [reliable and effective] antiemetic agent.

Dr. Camel's Conclusion

Just as a camel endures the harsh desert conditions, patients undergoing [chemotherapy or surgery] often face the discomfort of [nausea and vomiting]. This review emphasizes the important role of [granisetron] in easing this burden, offering a reliable and well-tolerated solution for managing these debilitating symptoms.

Date :
  1. Date Completed 2005-03-22
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

15561811

DOI: Digital Object Identifier

10.1634/theoncologist.9-6-673

Related Literature

Article Analysis
・Side Effects of granisetron
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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