Side Effects of granisetron: A Synthesis of Findings from 24 Studies

  1. Home
  2. Side Effects of granisetron
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of granisetron: A Synthesis of Findings from 24 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Side Effects of granisetron: A Synthesis of Findings from 24 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Main Research Findings

Granisetron is an effective drug for preventing nausea and vomiting caused by chemotherapy and radiation therapy, and postoperative nausea and vomiting. 17 , 21 , 8 , 14 , 12 Granisetron is a drug that inhibits serotonin receptors (5-HT3). Serotonin is a neurotransmitter that causes nausea and vomiting. 9 , 22 It has been shown that granisetron is more effective in preventing nausea and vomiting after chemotherapy when used in combination with dexamethasone than when used alone. 3 However, combining granisetron with dexamethasone may increase the frequency of side effects. 3 Granisetron also has the effect of promoting gastrointestinal motility and is used to treat nausea and vomiting caused by gastroparesis. 7 Granisetron is also expected to be effective in improving sexual dysfunction caused by antidepressants. 24 Granisetron is generally a safe drug, but it can cause serious side effects such as anaphylaxis. 1 Granisetron can alter the electrical activity of the heart, so caution is needed for patients with heart disease. Granisetron can interact with other medications, so it is important to tell your doctor about the medications you are taking. 4

Reasons for Side Effects

The side effects of granisetron are thought to be mainly due to the mechanism of action of the drug, namely the inhibition of serotonin receptors. 22 Serotonin is involved in various physiological functions as a neurotransmitter, and it is thought that various side effects occur due to inhibition of serotonin receptors.

Common Side Effects

Drowsiness

Granisetron can cause drowsiness. 22 Drowsiness can last for hours to days after taking granisetron. Avoid driving or operating machinery if you feel drowsy.

Constipation

Granisetron can cause constipation. 22 Constipation can last for days to weeks after taking granisetron. If you are concerned about constipation, talk to your doctor.

Headache

Granisetron can cause headache. 22 Headaches can last for hours to days after taking granisetron. If you are concerned about headaches, talk to your doctor.

Indigestion

Granisetron can cause indigestion. 22 Indigestion can last for days to weeks after taking granisetron. If you are concerned about indigestion, talk to your doctor.

Dizziness

Granisetron can cause dizziness. 22 Dizziness can last for hours to days after taking granisetron. If you feel dizzy, get up slowly.

Rash

Granisetron can cause rash. 1 Rash can last for hours to days after taking granisetron. If you are concerned about rash, talk to your doctor.

Anaphylaxis

Granisetron can cause anaphylaxis. 1 Anaphylaxis is a serious allergic reaction that can cause symptoms such as difficulty breathing, facial swelling, and hives. If you experience symptoms of anaphylaxis, seek immediate medical attention.

Side Effect Management

Drowsiness

Drowsiness can last for hours to days after taking granisetron. Avoid driving or operating machinery if you feel drowsy.

Constipation

Constipation can last for days to weeks after taking granisetron. If you are concerned about constipation, talk to your doctor.

Headache

Headaches can last for hours to days after taking granisetron. If you are concerned about headaches, talk to your doctor.

Indigestion

Indigestion can last for days to weeks after taking granisetron. If you are concerned about indigestion, talk to your doctor.

Dizziness

Dizziness can last for hours to days after taking granisetron. If you feel dizzy, get up slowly.

Rash

Rash can last for hours to days after taking granisetron. If you are concerned about rash, talk to your doctor.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that can cause symptoms such as difficulty breathing, facial swelling, and hives. If you experience symptoms of anaphylaxis, seek immediate medical attention.

Comparison of Studies

Commonalities in Studies

Many studies have shown that granisetron is effective in preventing nausea and vomiting caused by chemotherapy and radiation therapy, and postoperative nausea and vomiting. 17 , 21 , 8 , 14 , 12 It has also been shown that granisetron is generally a safe drug. 22 However, it has also been shown that granisetron can cause side effects such as drowsiness, constipation, and headache. 22

Differences in Studies

Some studies have shown that the frequency and severity of side effects of granisetron vary. 3 It has also been shown that granisetron may be more effective than other drugs in certain patient groups. 10 Furthermore, the effects and side effects may vary depending on the route of administration and dosage of granisetron. 7

Precautions for Real-Life Application

Granisetron is an effective drug for preventing nausea and vomiting caused by chemotherapy and radiation therapy, and postoperative nausea and vomiting, but it can cause side effects such as drowsiness, constipation, and headache. 22 When taking granisetron, talk to your doctor and understand the risks and benefits of side effects before taking it. Also, avoid driving or operating machinery while taking granisetron. If you experience symptoms such as drowsiness or dizziness, get up slowly. If you are concerned about constipation, talk to your doctor.

Limitations of Current Research

Research on granisetron is still not sufficient. In particular, there has not been enough research on the long-term side effects of granisetron. 22 Also, the effects and side effects of granisetron can vary from person to person. Therefore, more research is needed.

Future Research Directions

Future research needs to explore the long-term side effects of granisetron, the factors that influence the effects and side effects of granisetron, and the effectiveness of different routes of administration and dosages of granisetron. 22 Research is also needed on methods to reduce the side effects of granisetron.

Conclusion

Granisetron is an effective drug for preventing nausea and vomiting caused by chemotherapy and radiation therapy, and postoperative nausea and vomiting. 17 , 21 , 8 , 14 , 12 However, granisetron can cause side effects such as drowsiness, constipation, and headache. 22 When taking granisetron, talk to your doctor and understand the risks and benefits of side effects before taking it.

Literature analysis of 24 papers
Positive Content
22
Neutral Content
1
Negative Content
1
Article Type
3
2
2
6
23
1.

Palonosetron-Induced Anaphylaxis During General Anesthesia: A Case Report.

Author: ParkHyungjun, OhKyunghwan, LeeHoonhee, LeeJi Hyang, KangSun Myoung, ParkSo Young, KwonHyouk Soo, ChoYou Sook, MoonHee Bom, KimTae Bum

Postoperative nausea prevention
Postoperative vomiting prevention
Hypersensitivity reaction

This report describes a case of a 37-year-old male who developed severe hypersensitivity reactions to palonosetron, a 5-HT-3 receptor antagonist used for preventing postoperative nausea and vomiting, during surgery for kidney donation. This highlights the possibility of patients experiencing severe adverse reactions to palonosetron, even though it is generally considered safe.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

2.

Lack of efficacy of the 5-HT3 receptor antagonist granisetron in the treatment of acute neuroleptic-induced akathisia.

Author: PoyurovskyM, WeizmanA

Neuroleptic-induced akathisia

The 5-HT3 receptor subtype does not appear to be involved in the development of neuroleptic-induced akathisia, and 5-HT3 antagonists are ineffective in treating this condition.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Granisetron plus dexamethasone versus granisetron alone in the prevention of vomiting induced by conditioning for stem cell transplantation: a prospective randomized study.

Author: MatsuokaSahoko, OkamotoShinichiro, WatanabeRieko, MoriTakehiko, NagayamaHitomi, HamanoYasuharu, YokoyamaKenji, TakayamaNobuyuki, IkedaYasuo

Reduced emesis
Adverse reactions

This study compared the efficacy and toxicity of granisetron with dexamethasone to those of granisetron alone for antiemetic control in patients receiving high-dose chemotherapy. Granisetron with dexamethasone seemed superior to granisetron alone; however, the more frequent side effects may limit its use.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

The acute effect of tropisetron on ECG parameters in cancer patients.

Author: YavasOzlem, YaziciMehmet, ErenOnder, BorubanCem, ArtacMehmet, GencMine

Emesis prevention
ECG changes

This study aimed to determine the acute effects of tropisetron, a 5-HT3 receptor antagonist, on ECG parameters related to repolarization, heart rate, and systemic blood pressure in healthy volunteers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Granisetron vs dolasetron for acute chemotherapy-induced nausea and vomiting (CINV) in high and moderately high emetogenic chemotherapy: an open-label pilot study.

Author: TanMarianne, XuRichard, SethRahul

Chemotherapy-induced nausea and vomiting prophylaxis

Granisetron and dolasetron, both oral serotonin type 3 receptor antagonists, were compared for their effectiveness in preventing acute chemotherapy-induced nausea and vomiting.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Granisetron transdermal system improves refractory nausea and vomiting in gastroparesis.

Author: SimmonsKellie, ParkmanHenry P

Nausea and vomiting reduction
Constipation
Headaches
Skin rash

Granisetron transdermal patch was moderately effective in reducing refractory symptoms of nausea and/or vomiting from gastroparesis in 50% of patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Drugs for preventing postoperative nausea and vomiting.

Author: CarlisleJ B, StevensonC A

Reduced nausea
Reduced vomiting
Headache
Sedation

Eight drugs were found to be effective in preventing postoperative nausea and vomiting, but evidence for differences among them was unreliable.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

[Serotonin and anticancer drug-induced emesis].

Author: MinamiMasaru, EndoToru, HamaueNaoya, HirafujiMasahiko

5-HT(3) receptor antagonist
Nausea
Vomiting

Anticancer drug-induced nausea and vomiting are common and distressing side effects. Serotonin (5-HT) plays a significant role in mediating this emesis. 5-HT released from enterochromaffin (EC) cells in the intestinal mucosa stimulates vagal afferent nerves, activating the vomiting center in the brainstem. 5-HT(3) receptor antagonists are effective in blocking cisplatin-induced emesis, highlighting the importance of 5-HT in this process.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Japanese

11.

Is ondansetron more effective than granisetron for chemotherapy-induced nausea and vomiting? A review of comparative trials.

Author: VrabelMark

nausea and vomiting treatment
side effects

Ondansetron and granisetron are widely used 5-HT3 receptor antagonists for preventing chemotherapy-induced nausea and vomiting (CINV). A review of the literature suggests that both drugs have equal antiemetic efficacy in reducing or eliminating CINV.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis.

Author: WeibelStephanie, RückerGerta, EberhartLeopold Hj, PaceNathan L, HartlHannah M, JordanOlivia L, MayerDebora, RiemerManuel, SchaeferMaximilian S, RajDiana, BackhausInsa, HelfAntonia, SchlesingerTobias, KienbaumPeter, KrankePeter

Reduced PONV

Postoperative nausea and vomiting (PONV) is a common adverse effect of anesthesia and surgery affecting up to 80% of patients. While various antiemetic drugs are available, further research is needed to determine the most effective drugs with the fewest side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

Palonosetron and granisetron in postoperative nausea vomiting: A randomized double-blind prospective study.

Author: GugaleAmrita A, BhaleraoPradnya Milind

Reduced PONV

Granisetron and palonosetron, 5-HT3 receptor antagonists, are effective in preventing postoperative nausea and vomiting (PONV) after laparoscopic surgeries under general anesthesia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Comparative study of low-dose oral granisetron plus dexamethasone and high-dose metoclopramide plus dexamethasone in prevention of nausea and vomiting induced by CHOP-therapy in young patients with non-Hodgkin's lymphoma.

Author: NumbenjaponTontanai, SriswasdiChantrapa, MongkonsritragoonWichean, LeelasiriApichai, PrayoonwiwatWichai

Antiemetic efficacy
Extrapyramidal reactions

Low-dose oral granisetron combined with intravenous dexamethasone is more effective than high-dose metoclopramide in preventing both acute and delayed nausea and vomiting induced by chemotherapy in young patients with non-Hodgkin's lymphoma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Granisetron: is there a dose-response effect on nausea and vomiting?

Author: MinamiMasaru

Prevent nausea and vomiting

This article explores the dose-response effect of granisetron in preventing chemotherapy-induced nausea and vomiting. It examines whether there is a relationship between the dose of granisetron and its effectiveness in reducing these debilitating side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Pegylated liposomal doxorubicin: tolerability and toxicity.

Author: GoramA L, RichmondP L

Ovarian cancer treatment
Adverse reactions
Neutropenia
Plantar-palmar erythrodysesthesia
Stomatitis

This study evaluated the tolerability and toxicity of pegylated liposomal doxorubicin (PL-DOX) in women with recurrent or refractory ovarian cancer. The median number of cycles and cumulative dose were higher in patients who received PL-DOX after medical staff education, suggesting improved tolerability. Toxicity management strategies included dosage reduction, treatment delay, and discontinuation.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Granisetron: an update on its clinical use in the management of nausea and vomiting.

Author: AaproMatti

Improved antiemetic care
Improved safety profile
Reduced nausea and vomiting

This article provides an update on the use of the 5-HT3 receptor antagonist granisetron for managing nausea and vomiting induced by chemotherapy, radiation therapy, and surgical procedures. Granisetron has proven effective and well-tolerated in various patient populations, including those refractory to other antiemetics, those with hepatic or renal impairment, and children. Its safety profile and minimal drug interactions make it a preferred option for elderly cancer patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

22.

Preclinical and clinical pharmacology of the 5-HT3 receptor antagonists.

Author: WolfH

Antipsychotic effect
Fibromyalgia treatment
Nausea and vomiting treatment
Pain relief
Constipation
Headache

5-HT3-receptor antagonists are potent and selective inhibitors of the 5-HT3-receptor, with a wide range of therapeutic applications. They effectively treat chemotherapy-induced emesis, radiotherapy-induced emesis, and post-operative emesis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

24.

A placebo-controlled, crossover trial of granisetron in SRI-induced sexual dysfunction.

Author: NelsonE B, ShahV N, WelgeJ A, KeckP E

Sexual dysfunction reversal

Many people taking serotonin reuptake inhibitors (SRIs) experience sexual side effects, which are thought to be caused by direct serotonin activity. This study investigates the effect of granisetron, a serotonin antagonist, on sexual dysfunction in patients taking SRIs. The study randomly assigned patients to receive either granisetron or placebo in a crossover design.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.